HEALTHY ADULTS

This early-stage trial tested whether an experimental HIV vaccine is safe and can trigger an immune response. It involved 68 healthy adults who were not infected with HIV. The vaccine uses a DNA-based platform (DREP) alone or with a protein boost. The main goal was to check for s…

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This study tested a home-use device that uses two types of light to kill bacteria on teeth. 20 healthy adults used the device along with brushing, and researchers measured how much plaque remained compared to brushing alone. The goal was to see if the light treatment could clean …

This study tested whether a chicken extract supplement can improve mental energy in 189 healthy adults aged 35-64. Participants took the supplement or a placebo, and researchers measured fatigue, focus, reaction time, and brain activity. The goal was to see if the extract could h…

This study tested whether omega-3 supplements (a healthy fat found in fish oil) can reduce stress, anxiety, and depression while improving memory and sleep. 64 highly stressed Saudi adults took either omega-3 or a placebo daily for three months. Results showed that those taking o…

This study looked at whether a video game that combines physical exercise with cognitive challenges can improve attention and working memory in healthy adults. 49 participants were assigned to different training groups and tested over 8 weeks. The goal was to understand if the co…

This study looked at how one session of aerobic exercise at different intensities affects brain blood flow, stress hormones, and memory in healthy adults and those with mild stress. Twenty-four people aged 20-40 took part. The goal was to understand the immediate benefits of exer…

This study tested two different pill versions of an experimental Pfizer drug in 24 healthy adults. The goal was to see how well each form is absorbed by the body, not to treat any disease. Participants received a single dose of each pill in a random order, and researchers measure…

This early-stage study tested whether a new compound called CHI-554 is safe when taken with alcohol. 29 healthy adults participated in a double-blind trial. The main goal was to check for side effects and changes in blood pressure and liver function. This study does not aim to tr…

This study tested how two common drugs—cyclosporine (an immunosuppressant) and clarithromycin (an antibiotic)—change the way the body processes an experimental medicine called PF-07328948. Twenty-six healthy adults took part. The goal was to gather safety and drug-level informati…

This early-stage study tested a new medicine called PF-07940369 in 30 healthy adults to see if it is safe and how the body handles it. Participants took the drug or a placebo by mouth for 14 days. The study is complete and helps decide if further testing is possible.

This study looked at how the antifungal drug fluconazole changes the way the body processes an experimental medicine called PF-07248144. Twelve healthy adults took PF-07248144 alone and then again with fluconazole. Researchers measured drug levels in the blood and checked for sid…

This study looked for substances in blood and urine that can show what a person has eaten, instead of relying on memory or food diaries. Thirty-two healthy adults ate specially prepared meals for a week, and researchers tested their blood, urine, and stool samples. The goal was t…

This study looked at how the drug carbamazepine changes the way the body handles a new medicine called PF-07220060. Fourteen healthy adults took PF-07220060 alone and then again after taking carbamazepine for several days. Blood samples were collected to measure drug levels, help…

This study looked at how healthy adult men process the experimental medicine PF-07104091. Nine participants took the drug by mouth and later received a tiny radioactive tracer dose into a vein. Researchers measured how much of the drug entered the blood and how it was removed in …

This study looked at how taking itraconazole (a strong CYP3A4 inhibitor) and probenecid (a potent UGT2B7 inhibitor) changes the way the body processes a single dose of PF-07220060. 25 healthy adults participated in this completed Phase 1 trial. The goal was to gather safety and d…

This study looked at how different levels of liver damage affect the way the body handles a single dose of the drug KP-001. Twenty-four adults, some with healthy livers and some with mild to moderate liver problems, took part. The goal was to see if liver impairment changes drug …

This study looked at how the drug carbamazepine changes the way the body handles another drug called PF-07248144. Twelve healthy adults took PF-07248144 alone and then with carbamazepine. Researchers measured drug levels in the blood to understand the interaction and check for sa…

This study followed more than 5,000 adults aged 55–70 over nearly ten years to learn how retirement affects loneliness, physical activity, and overall well-being. Researchers interviewed participants three times between 2013 and 2019. The goal was to gather information, not to te…

This study looked for chemicals in blood and urine that can show what foods people have eaten, like beef, beans, and eggs. Thirty healthy adults ate controlled meals and gave samples over several days. The goal is to develop more accurate ways to measure diet than asking people t…

This study looked at whether taking a daily prebiotic supplement called SuperHMO (made from human milk sugars) for 30 days can improve gut health in healthy adults aged 18 to 40. 32 participants either took the supplement or a placebo. Researchers measured changes in gut bacteria…

This study looked at how four different versions of Urolithin A (Mitopure) are absorbed by the body in 48 healthy adults aged 18 to 45. Participants took a single dose of one formula, and researchers measured the amount of Urolithin A in their blood over time. The goal was to und…

This study looked at how bismuth subsalicylate (the active ingredient in Pepto-Bismol) changes the bacteria in the gut. 34 healthy adults took the medicine for 2 days, and researchers compared their stool samples before and after. The goal was to learn more about how this common …