HEADACHE

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study looks at whether a 16-week supervised aerobic exercise program, combined with a session on pain education, can reduce migraine-related disability and improve quality of life in women aged 18 to 48. One hundred participants will be randomly assigned to either the exerci…

This study tests whether a machine learning algorithm can help personalize a non-invasive brain stimulation treatment (rTMS) for veterans and active military personnel suffering from Gulf War Illness-related headaches and body pain. About 140 participants will receive active rTMS…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This study tests a lifestyle behavior program to help people with chronic migraine. Researchers want to see if the program is practical and liked by participants, and if it reduces how often and how bad migraines are. They will also look at certain molecules in the blood that mig…

This study looks at whether the position of a neck muscle before dry needling changes how well the treatment works for chronic neck pain. About 80 adults with neck pain lasting over 3 months will be randomly assigned to have the muscle stretched or shortened during two needling s…

This study tests a noninvasive, personalized brain stimulation treatment called TMS for people aged 18-65 with chronic symptoms after a concussion, such as headache, dizziness, brain fog, or anxiety. Participants will have a 66% chance of receiving active TMS and a 33% chance of …

This study tests a new way to treat headaches by placing a tiny needle in the ear and using a mild electrical current to calm the vagus nerve. Researchers will measure changes in facial temperature and heart rate to see if the treatment works. The study needs 60 adults who get at…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce chronic headaches in people who had a mild traumatic brain injury. Researchers will track headache severity, sleep, and daily function in 60 adults over time. The goal is to find a drug-fre…

This study tests whether a numbing injection in the face can reduce headache and the need for strong painkillers in people who have had a brain bleed. About 195 adults will receive either the active injection or a placebo. The goal is to see if this approach is safe and effective…

This study tests if osteopathic manipulative treatment (OMT) — a hands-on therapy — can reduce muscle stiffness and improve jaw motion in people with neck pain and headaches. About 30 adults aged 19 to 65 with symptoms lasting over a month will receive OMT and undergo tests like …

This study looked at whether surgical masks or N95 masks work better to reduce physical symptoms like headache, fatigue, and muscle pain caused by surgical smoke in operating room nurses. 38 nurses wore each type of mask for four weeks and reported their symptoms. The results sho…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study tests whether a numbing injection inside the nose can help relieve severe headaches caused by a type of brain bleed called subarachnoid hemorrhage. About 40 adults with a secured aneurysm will receive either the nerve block plus standard pain meds or standard meds alon…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can prevent headaches after a brain aneurysm procedure. About 440 adults will either get the real stimulation or a fake version. The goal is to find a safe, drug-free way to reduce pain …

This study is collecting information from 50,000 people with headaches to build a better system for diagnosing and treating them. Researchers will use medical records, brain scans, and genetic data to understand different headache types. The goal is to help doctors make more accu…

This study aims to find out which patient factors influence how well a nerve block works for medication-overuse headache. Researchers will give 70 adults an ultrasound-guided injection and track their pain and medication use for one month. The goal is to better predict who will b…

This online registry tracks pregnant women with migraines to see if a nerve-stimulation device (CEFALY) is safe and helpful. Participants don't have to change their current treatment or use the device. They fill out short surveys online over 12 months. The goal is to gather real-…