FUNCTIONAL DYSPEPSIA

This study tests a new way to treat children with gut-brain disorders like cyclic vomiting and functional dyspepsia. The therapy uses a mild electrical nerve stimulation to the ear, personalized based on each child's nerve activity. The goal is to improve quality of life and redu…

This study looks at how different FODMAP diets affect gut bacteria, gut barrier function, and symptoms in people with functional gastrointestinal disorders like IBS. About 60 adults will follow either a low FODMAP, gentle FODMAP, or standard dietary advice for two weeks. Research…

This study tests whether two medications, amitriptyline and trifluoperazine, can reduce stomach symptoms in people with functional dyspepsia—a condition where the stomach feels upset without a clear cause. About 120 adults will take one of the drugs or stick with standard treatme…

This study tests whether a natural extract from the hyacinth bean (EDL) can reduce stomach symptoms like pain, fullness, and burning in people with functional dyspepsia. About 100 adults will take EDL or a placebo daily for 12 weeks. Researchers will measure symptom changes using…

This study tests if a digital hypnotherapy program can reduce stomach and gut symptoms like pain, bloating, and nausea. Researchers will enroll 100 adults with upper GI disorders (e.g., functional dyspepsia) and measure changes using symptom questionnaires. The approach is non-in…

This study tests whether pressing small seeds on specific ear points can help people with functional dyspepsia (chronic stomach discomfort) who also have insomnia. Researchers will track symptom relief and sleep quality in 176 adults over 8 weeks, and explore how the treatment af…

This study tests whether using virtual reality can help relieve stomach pain and other symptoms in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers at Mayo Clinic will enroll 30 adults who meet specific criteria. Parti…

This study tests whether ketotifen, a drug that stabilizes certain immune cells, can reduce stomach pain in children aged 8-17 with functional dyspepsia and high levels of eosinophils in the gut. Participants will receive both ketotifen and a placebo at different times to compare…

This study tests two digital treatments for children aged 8-17 with chronic stomach pain caused by gut-brain interaction disorders. After a 4-week online education program, participants are randomly assigned to either internet-based cognitive behavioral therapy (iCBT) or gut-dire…

This study tests a daily supplement containing two types of probiotics and ginger extract in 198 adults with functional dyspepsia, a condition causing stomach pain, fullness, and burning. Participants take one capsule daily for 8 weeks. Researchers will measure changes in symptom…

This study tests whether a probiotic called Clostridium butyricum can help reduce anxiety and depression in people with functional dyspepsia (a common stomach disorder). 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard stomach medication. …

This study tests whether a probiotic called Bacillus coagulans can reduce anxiety and depression in people with functional dyspepsia, a common stomach disorder. 180 adults will receive either the probiotic or a placebo for 4 weeks, alongside standard treatment. The main goal is t…

This study tests whether combining a nerve-stimulating device (placed on the ear) with behavioral therapy can reduce stomach pain and anxiety in people with functional dyspepsia, a condition where the stomach feels upset without a clear cause. Researchers will track symptoms and …

This study tests whether press needles (small needles taped to the skin) on body and ear acupuncture points, combined with medication, can reduce symptoms and improve quality of life in people with functional dyspepsia (stomach pain or discomfort without a clear cause). About 38 …

This study tests a type of talking therapy called exposure-based cognitive behavioral therapy (CBT) for adults who have both functional dyspepsia (a stomach condition causing pain and fullness) and avoidant/restrictive food intake disorder (ARFID), leading to weight loss. Fifty p…

This study tests a non-invasive device called Gastric Alimetry that records stomach electrical activity in people with functional dyspepsia or gastroparesis. Researchers will compare recordings taken before and during medication to see if the device can predict which treatment wo…

This study aims to find out how many relatives of people with celiac disease have non-celiac wheat sensitivity (NCWS) or other gut issues like IBS. Participants will follow a strict wheat-free diet for 6 weeks and report their symptoms. The goal is to better understand the link b…

This study is creating a registry of 250 people with symptoms of gastroparesis or functional dyspepsia, such as nausea, vomiting, and abdominal pain. Participants will fill out questionnaires, take a nutrient drink test, and have a gastric emptying scan. The goal is to collect da…

This study looks at whether people with a certain stomach lining condition (chronic atrophic gastritis) have different indigestion symptoms than those without it. Researchers will compare symptom patterns in about 315 adults who recently had an endoscopy. The goal is to better un…

This study uses a noninvasive device to stimulate a nerve in the ear and see how it changes brain and stomach activity. Researchers will use MRI scans to measure these effects in healthy adults and people with stomach discomfort. The goal is to better understand how the brain and…

This study looks at whether women with functional dyspepsia (a condition causing stomach pain and discomfort without a clear cause) have different body composition than healthy women. Researchers will use a simple, non-invasive test called bio-electrical impedance to measure fat …