DRUG RESISTANT EPILEPSY

This study tests a new device called the iVEAcare Neuromodulation System for people with drug-resistant epilepsy, whose seizures are not controlled by medication. About 30 participants will receive the implant and be followed for up to 5 years. Researchers will check for side eff…

This study tests whether a noninvasive technique called temporal interference (TI) stimulation can reduce seizures in people aged 6 to 60 with drug-resistant epilepsy. Researchers apply TI stimulation to deep brain areas using external electrodes, aiming to calm overactive circui…

This study tests whether low intensity focused ultrasound (LIFU) — sound waves delivered through a wearable headband — can reduce seizures in adults with drug-resistant epilepsy. Participants wear the device during treatment sessions, and researchers track seizure frequency and b…

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce seizures in people with drug-resistant epilepsy. About 60 participants will receive either real or sham (fake) stimulation over 10 days. The goal is to see if this approach safely lowers se…

This study tests whether focused ultrasound can safely reduce seizures in people with drug-resistant epilepsy. Twenty adults who have not responded to at least two seizure medications will receive ultrasound treatment to interrupt brain circuits causing seizures. Researchers will…

This pilot trial tests whether repeated sessions of pulsed low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite medication will receive the ultrasound treatment. Researchers wi…

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

This study tests a hat that shines infrared light on the head for 30 minutes each day. The goal is to see if it can safely reduce seizures in people with drug-resistant epilepsy. Thirteen adults will try it for six months, and researchers will track seizure changes and comfort.

This study tests a tablet-based tool called the Epilepsy Visit Planner for adults with drug-resistant epilepsy. The tool helps patients set goals and share concerns before doctor visits. Researchers want to see if it improves communication and quality of life. About 152 participa…

This study looks at people with drug-resistant focal epilepsy who are already scheduled for a brain-mapping procedure called SEEG. At the end of that procedure, doctors sometimes use heat (thermocoagulation) to destroy small areas of brain tissue that cause seizures. The study wi…

This study tests whether advanced MRI scans can accurately identify the brain networks responsible for seizures in people with drug-resistant epilepsy. Participants, who are already scheduled for invasive electrode monitoring, will receive an additional hour-long MRI. Researchers…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. Researchers want to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy …

This study looks at how the bacteria in your gut might affect epilepsy that doesn't get better with standard medicines. Researchers will follow 120 people aged 3 to 50 who have drug-resistant epilepsy and are starting a new treatment like surgery or a special diet. The goal is to…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study compares two advanced brain-mapping techniques—magnetoencephalography (MEG) and high-resolution EEG (EEG HR)—to see which better locates the seizure-causing area in people with drug-resistant epilepsy who are candidates for surgery. Researchers will enroll 100 particip…

This study looks at how seizures change the brain's wiring in children with drug-resistant focal epilepsy. Researchers will use special EEG recordings and MRI scans to measure brain connections in 82 children. The goal is to understand if ongoing seizure activity causes lasting d…

This study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…