Brain scan clues may predict who benefits from epilepsy procedure

NCT ID NCT07399327

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at people with drug-resistant focal epilepsy who are already scheduled for a brain-mapping procedure called SEEG. At the end of that procedure, doctors sometimes use heat (thermocoagulation) to destroy small areas of brain tissue that cause seizures. The study will use advanced MRI scans and blood tests to see if changes in the brain's barrier and electrical signals can predict who will have fewer seizures after the heat treatment. The goal is to find better ways to choose the right targets for this procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SEEG-guided radiofrequency thermocoagulation (RFTC)
What this could lead to
If successful, this could help doctors better select which brain targets to treat with thermocoagulation, improving seizure control for people with drug-resistant epilepsy.
What could go wrong
This is an early observational study with only 45 participants, so results may not apply to everyone. It focuses on understanding mechanisms, not proving a new treatment works.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy focal epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Assistance Publique - Hôpitaux Marseille

    RECRUITING

    Marseille, France

    Contact

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