CORONARY ARTERY DISEASE (CAD)

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This study will test whether taking ginger supplements for two months can lower inflammation and oxidative stress in people with coronary artery disease. Fifty adults with confirmed heart disease will be randomly assigned to receive either ginger extract or a placebo. Researchers…

This study looks at whether taking royal jelly and propolis (natural bee products) for two months can lower inflammation and improve heart health in 50 adults with coronary artery disease. Participants will be randomly assigned to receive the supplements or a placebo, and researc…

This study tests if using only drug-coated balloons is as safe and effective as stenting for treating blocked heart arteries at branch points. About 272 people with chronic coronary syndrome will be randomly assigned to one of the two treatments. Researchers will track deaths, he…

This study tests a new device called the Shockwave C2 Aero, which uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 200 people with coronary artery disease will be enrolled across 8 U.S. sites. The goal is to see if the device works saf…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This study tracks 1,200 people with coronary artery disease who receive a drug-coated balloon instead of a metal stent during angioplasty. The goal is to see if this approach reduces heart-related deaths, heart attacks, and the need for repeat procedures. Researchers hope to conf…

This study tests whether heart attack patients with high bleeding risk can safely take blood thinners for only one month after a special drug-coated stent, instead of the usual 12 months. About 468 participants will be randomly assigned to the shorter or standard therapy. The goa…

This Phase 3 trial tests whether a drug called EA-230 can help people recover faster after coronary artery bypass surgery. About 300 adults scheduled for elective bypass surgery will receive either EA-230 or a placebo during the operation. Researchers will measure how long partic…

This study tests whether a combination of minimally invasive bypass surgery (through small chest incisions) and stents can match or beat standard open-heart bypass for people with blockages in all three main heart arteries. The trial will enroll 250 adults and measure complicatio…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of the usual 3 to 12 months. The goal is to see if this shorter treatment reduces bleeding risks without increasing heart attacks, …

This study will compare two modern treatments for blocked coronary arteries: a new-generation bioabsorbable scaffold (a temporary mesh that dissolves over time) and a drug-coated balloon (a balloon that releases medication to prevent re-blockage). 150 patients with blockages in l…

This study looks at whether a special heart scan (CZT-SPECT) can better predict heart attacks, strokes, and heart failure in people with chronic kidney disease. Current tests often miss heart problems in these patients. The study will follow 283 participants for two years to see …

This study tests a new, contactless camera technology that measures heart rate, blood pressure, and heart disease risk from a short video of your face. Researchers will compare these readings to standard medical tests in 300 adults aged 30 and older in Jakarta. If accurate, this …

This study will test a computer algorithm called ECGio that analyzes electrocardiograms (ECGs) to see if it can accurately detect significant coronary artery disease (blockages in heart arteries). Researchers will compare ECGio's results to standard imaging tests like angiograms …

This study tests an 8-week mindfulness program designed to reduce anxiety and improve quality of life in women with coronary artery disease. Researchers will enroll 70 women who have had CAD for at least a month and have elevated anxiety. The program includes meditation, breathin…

This study tests whether applying an ice bag to the groin area after a heart procedure (called PCI) can reduce pain and bruising. Sixty adults who had the procedure through the femoral artery will receive ice therapy for 20 minutes at a time. Researchers will measure pain levels …

This observational study will follow 3000 patients with severely calcified coronary arteries who undergo a procedure to open the blockages (PCI). Researchers will track outcomes like heart attacks and repeat procedures over time. The goal is to learn which techniques work best in…

This study looks at whether adding a special heart function test (coronary function testing) to the standard artery-opening procedure (angioplasty) can better relieve chest pain and improve quality of life. About 450 adults with a significant blockage in a major heart artery will…

This study looks at how well hospitals follow guidelines for blood thinner use after heart stent placement. It will enroll 3,500 patients with acute coronary syndrome who are at high risk for bleeding. Researchers will track their treatment and outcomes for 12 months to see if a …

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will follow 560 adults with suspected heart issues to see if sleep apnea patterns can predict future heart events li…

This observational study will check if levels of a fatty substance called lipoprotein(a) in the blood are linked to calcium buildup in heart arteries. About 150 adults at intermediate heart risk will get a CT scan and a blood test. The goal is to see if Lp(a) can help detect earl…

This study looks at whether a 6-minute pegboard and ring test—a simple, low-cost task of moving rings between pegs—can reliably measure upper body exercise capacity in people with coronary artery disease. Researchers will compare the results to standard cardiopulmonary exercise t…