CORONARY ARTERY DISEASE (CAD)

This study is creating a large registry to track the real-world performance of drug-coated balloons, a newer treatment for blocked heart arteries. Researchers will follow 1,200 patients in Spain and Portugal who receive this treatment to see how well it works and how safe it is c…

This study compares two surgical approaches for patients with severe blockages in all three main heart arteries. Researchers want to see if a less invasive 'hybrid' procedure (combining small-incision bypass with artery stenting) leads to fewer complications and faster recovery t…

This study aims to see which of two common treatments works better for opening clogged heart arteries: a new type of dissolving stent or a medicated balloon. It will involve 150 patients with significant artery blockages who need treatment. Researchers will randomly assign patien…

This large German study is testing a new nationwide care model for people with new chest pain and suspected heart disease. It aims to get doctors to use safer, more accurate CT scans more often instead of invasive procedures. The goal is to see if this approach reduces heart atta…

This study is testing if a much shorter course of dual blood-thinning therapy is as safe and effective as the standard longer course for seniors who get a heart stent. It will enroll 1,700 patients aged 65 and older. One group will take two blood thinners for just 7 days, then on…

This study is for people who have had a heart attack and received a stent, but are at high risk for both future clots and serious bleeding. It will test if using a special stent and only one month of strong blood thinners is as safe and effective as using standard stents with a f…

This study compares two common heart procedures—bypass surgery (CABG) and stent placement (PCI)—for people with weakened heart pumps and multiple clogged arteries. Researchers will follow 358 patients for 4 years to see which approach leads to better survival, fewer heart problem…

This study is testing a new injectable drug called SRSD107 for people with chronic coronary artery disease (CAD) or peripheral artery disease (PAD). The main goals are to see how the drug behaves in the body, if it's safe, and how it affects certain blood markers. About 104 parti…

This study aims to see if a drug-coated balloon is as good as or better than a drug-coated stent for treating blocked heart arteries in high-risk patients. It will enroll over 2,100 adults with coronary artery disease who have additional health risks like diabetes or kidney probl…

This trial is testing a new drug called EA-230 to see if it helps people recover faster after heart bypass surgery. The goal is to shorten the time patients need to stay in the hospital and intensive care unit (ICU) and reduce serious complications. About 300 adults scheduled for…

This study is testing how well a computer algorithm called ECGio can detect significant blockages in heart arteries. Researchers will compare ECGio's accuracy against standard imaging tests in 978 adults suspected of having heart disease. The goal is to see if this tool could hel…

This study is testing if applying an ice pack to the groin area can help patients feel better after a common heart procedure called PCI. Researchers want to see if the cold pack reduces pain and limits bruising where the catheter was inserted. They will enroll 60 adults who have …

This study aims to see if performing extra tests on heart function during a standard stent procedure leads to better relief of chest pain and improved quality of life. It will compare 450 patients who get the extra tests and targeted treatment to those who only get the standard s…

This study is testing whether a mindfulness-based stress reduction program can help women with coronary artery disease feel better. It aims to see if the program improves their quality of life, reduces anxiety, and helps them feel more empowered in managing their condition. The s…

This study aims to see if a simple 6-minute pegboard test is a reliable way to measure arm exercise capacity in people with coronary artery disease. Researchers will have 32 stable patients perform the pegboard test and a more complex exercise test to compare results. The goal is…

This study aims to understand if high levels of a specific blood fat called Lipoprotein(a) are linked to more calcium buildup in the heart's arteries, as seen on a special CT scan. Researchers will enroll 150 adults at intermediate risk for heart disease who are already scheduled…

This study aims to understand how repeated drops in oxygen levels during sleep in people with obstructive sleep apnea (OSA) might damage the tiny blood vessels in the heart, a condition called coronary microvascular dysfunction (CMD). Researchers will follow 560 adults with suspe…

This study aims to understand and improve the real-world use of dual blood-thinning therapy (DAPT) in patients who have had a heart attack and received a stent. It will follow 3,500 patients at high risk for bleeding for one year to see how their treatment is managed and to test …

This study aims to find out which of two common anesthesia drug combinations is better at maintaining healthy blood flow to the brain during heart bypass surgery. It will involve 40 patients with coronary artery disease and a weakened heart pump. Researchers will use a special fo…