CORONARY ARTERY DISEASE (CAD)

This study will track 1,200 people with coronary artery disease who receive a drug-coated balloon instead of a metal stent during angioplasty. The balloon delivers medication to prevent the artery from narrowing again, without leaving a permanent implant. Researchers want to see …

This study compares a newer, less invasive heart bypass surgery (hybrid revascularization) to the standard open-chest bypass surgery in 250 people with three blocked heart arteries. The goal is to see if the less invasive approach leads to fewer complications and a quicker recove…

This study will track 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent during a procedure to open blocked heart arteries. The goal is to see how well the stent works and how safe it is in real-world use. Participants must be 18 or o…

This study compares two treatments for complex coronary artery disease: a drug-coated balloon and a drug-eluting stent. About 2,184 high-risk patients will be randomly assigned to one of the two procedures. The goal is to see if the balloon works as well as the stent at preventin…

This study looks at whether older adults (65+) who get a heart stent can safely stop one of their blood thinners (aspirin) after just 7 days instead of taking it for months. The goal is to see if this shorter treatment reduces bleeding risks without raising the chance of heart at…

This study tests if using only drug-coated balloons is as safe and effective as stenting for treating certain types of heart artery blockages. About 272 adults with chronic coronary syndrome will be randomly assigned to one of the two treatments. Researchers will track deaths, he…

This study tests two ways to open blocked heart arteries without leaving a permanent metal implant. One uses a new scaffold that dissolves over time, the other uses a balloon coated with medicine. 150 patients will be randomly assigned to one of the two treatments and followed fo…

This study tests a device that uses sound waves to break up calcium deposits in heart arteries, making it easier to place stents. About 200 adults with hardened arteries will be treated and followed for 30 days to see if the device works safely. The goal is to improve blood flow …

This study looks at whether a shorter course of blood thinners after heart stenting can reduce bleeding without increasing heart attacks or strokes. It involves 468 adults with acute coronary syndrome who have both high risks of clotting and bleeding. Participants will either get…

This study looks at whether adding special heart function tests to the standard stent procedure (angioplasty) can better relieve chest pain and improve quality of life in people with blocked heart arteries. About 450 adults with significant blockages in a major heart artery will …

This study will check if a computer program called ECGio can accurately find significant blockages in heart arteries using only an ECG (electrocardiogram). Researchers will compare ECGio's results with standard imaging tests like angiograms and CT scans in nearly 1,000 adults sus…

This study tests a new therapy called EA-230 to see if it helps people recover faster after coronary artery bypass surgery. In an earlier study, those who got EA-230 spent less time in the ICU and hospital and had fewer serious problems. This Phase 3 trial will involve 300 adults…

This study tests whether a mindfulness-based stress reduction program can improve quality of life, reduce anxiety, and increase feelings of empowerment in women with coronary artery disease. About 70 women aged 18-50 will participate. The goal is to see if learning mindfulness sk…

This study is testing if placing an ice pack on the groin area can help patients feel better after a common heart procedure. Researchers want to see if this simple method reduces pain and bruising where the needle went in. They are looking for 60 adults who have just had this pro…

This study is a large registry that will observe 3,000 people with severely calcified coronary artery disease who are undergoing a procedure to open their blocked arteries (PCI). The goal is to collect real-world data on different treatment techniques and tools to see which work …

This study looks at 150 adults aged 40-70 who are at medium risk for heart disease. Researchers want to see if higher levels of a blood fat called lipoprotein(a) are linked to more calcium buildup in the heart arteries, as seen on a CT scan. Participants will get a CT scan and gi…

This study tests if a contactless camera technology (rPPG) can accurately measure heart rate, blood pressure, and heart disease risk just by scanning your face for 30-60 seconds. Researchers will compare these results with standard medical tests in 300 adults aged 30 and older in…

This study involves 3,500 adults with acute coronary syndrome who have received a heart stent and are at high risk for bleeding. Researchers will test a new quality control system to see if it helps doctors better manage antiplatelet medications, balancing clot prevention with bl…

This study looks at whether a simple, 6-minute pegboard and ring test can reliably measure upper body exercise capacity in people with coronary artery disease. Researchers will compare the pegboard test results with a standard cardiopulmonary exercise test. The goal is to find a …

This study looks at how low oxygen levels during sleep (from obstructive sleep apnea) are connected to problems in the tiny blood vessels of the heart. Researchers will monitor 560 adults with suspected heart issues using sleep tests and heart scans. The goal is to see if certain…