CORONARY ARTERY DISEASE (CAD)

This study tests whether adding a low-dose anti-inflammatory drug called colchicine to standard heart treatments can lower the risk of major heart problems like heart attacks and strokes. About 3,800 adults with stable coronary artery disease and non-blocking plaque will be rando…

This study looks at two ways to manage blood flow during off-pump heart bypass surgery: using body positioning (with or without a small amount of medication) versus using only medication. About 50 adults with coronary artery disease who need first-time bypass surgery will take pa…

This study tests a new drug called SRSD107, given as a shot under the skin, in people with long-term coronary or peripheral artery disease. The goal is to see if it can safely reduce a clotting factor in the blood, potentially lowering the risk of heart attacks or strokes. About …

This study looks at two ways to fix a common problem after heart stent placement: when the stent doesn't fully expand. The trial will compare a new technique called intravascular lithotripsy (using sound waves) with standard high-pressure balloons. About 80 adults with narrowed s…

This study tests a new way of caring for people with new-onset stable chest pain who may have coronary artery disease. Instead of routinely using a heart catheterization, the new model promotes a less invasive CT scan first. About 3,369 adults across 16 regions in Germany will ta…

This study looks at how well the SUPRAFLEX CRUZ stent works in people with blocked heart arteries. About 508 adults who already got the stent as part of their normal care will be followed for 12 months. Researchers will track serious heart problems like heart attacks or the need …

This study is checking how well a new drug-coated heart stent (Coroflex ISAR NEO) works and how safe it is in 3,000 people with narrowed heart arteries. Participants get the stent as part of their regular care, and doctors will track heart-related events like heart attacks or the…

This study compares two common heart procedures—bypass surgery (CABG) and stents (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and imp…

This study compares two treatments for people with completely blocked heart arteries (chronic total occlusions). One uses a drug-coated balloon to open the blockage, sometimes with a stent; the other uses a stent alone. The goal is to see if the balloon approach works as well or …

This study tests whether a new injection called XTR004, used during a PET heart scan, can better identify significant blockages in the heart's arteries compared to standard scans. About 395 adults with known or suspected stable coronary artery disease will receive the injection a…

This study is enrolling 816 adults with coronary artery disease to compare two imaging techniques: a non-invasive CT scan (CCTA) and an invasive camera placed inside the heart arteries (OCT). The goal is to see how well the CT scan can identify dangerous plaque and guide treatmen…

This study tests whether an artificial intelligence (AI) program that analyzes facial images can help screen for coronary artery disease (CAD) in people at high risk (those with diabetes, high blood pressure, or over age 65). About 1,392 participants will have their photo taken a…

This study tests whether fexuprazan, a new stomach acid reducer, can prevent upper gastrointestinal bleeding in 400 heart patients at high risk for bleeding who are taking two blood thinners after coronary stent placement. Participants receive either fexuprazan or the standard dr…

This study tests whether using special CT scans to monitor plaque buildup in the heart arteries can help prevent major heart problems like heart attacks and strokes. About 3,100 adults with non-obstructive coronary artery disease will be randomly assigned to either a management p…

This study looks at how people with coronary artery disease (CAD) respond to arm versus leg exercise. Researchers will measure things like blood vessel stiffness, muscle oxygen levels, and energy use during both types of exercise. The goal is to understand which test gives a bett…

This study will track 100 adults using Fitbit smartwatches to see if daily data like heart rate, sleep, and steps can help assess heart health and predict disease risk. Researchers will compare wearable data with standard heart health scores. The goal is to learn whether smartwat…

This study is collecting information from 5,000 people with coronary artery disease who are scheduled for a stent procedure. Doctors will use a special CT-based tool called PCI Navigator to see if it helps them plan the procedure better than using X-ray images alone. The goal is …

This study tracks 100 men aged 30-75 who had a heart procedure (stent placement) to see how their erectile function changes over 6 months. Half had a recent heart attack, half had stable chest pain. Researchers will use a standard questionnaire to compare the two groups and under…

This study looks at 60 people with stable chest pain (angina) and two blocked heart arteries. During a heart catheter procedure, doctors will inflate a tiny balloon inside each blockage while the person exercises on a bike. They measure how much blood flow drops before pain start…

This study will use artificial intelligence to analyze heart CT scans from 10,000 adults to better predict who is at risk for a heart attack. Participants will have a CT scan, blood tests, and answer health questions. The goal is to see if AI can find hidden signs of heart diseas…

This study looks at whether a special ultrasound measurement of blood flow in all three main heart arteries can help predict serious heart events like heart attacks or the need for additional procedures within a year. About 494 adults with coronary artery disease will have an ult…

This study follows 1000 adults with type 2 diabetes who have already had a heart CT scan. Researchers will repeat the scan to measure how fatty plaque builds up in heart arteries over time. The goal is to better understand which patients are at highest risk for heart attacks, wit…

This study looks at over 12,000 people with coronary heart disease who take blood thinners. These drugs can cause serious clots or bleeding. Researchers will use advanced tests on blood samples and combine them with medical images and computer models to find better ways to predic…

This study looks at whether it is safe to use the ulnar artery in the same arm as a blocked radial artery for heart procedures like angiography or angioplasty. About 127 adults with a blocked radial artery will be observed to see if this approach causes serious complications or a…

This study looks at two different drug combinations used to put patients to sleep before heart bypass surgery. The goal is to see which one better keeps blood flowing to the brain during the procedure. The study includes 40 adults with heart disease and weak heart pumping functio…