CORONARY ARTERY DISEASE (CAD)

This trial tests a 12-week home-based digital cardiac rehabilitation program for people with coronary artery disease. It aims to improve heart health, reduce hospital visits, and enhance quality of life, especially for older adults, women, and those with other health issues. The …

This study is testing whether a drug-coated balloon is as good as a drug-eluting stent for treating complex coronary artery disease in high-risk patients. About 2,184 participants will be randomly assigned to receive one of the two treatments. The main goal is to see if the ballo…

This study tests whether a home-based cardiac rehab program delivered through a mobile app can reduce plaque buildup in the heart arteries of people with mild to moderate blockages. 176 participants will either get the app-based program (with exercise plans, diet advice, and ment…

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 358 people with weak hearts (ejection fraction 40% or less) and multiple blocked arteries. The goal is to see which approach leads to better survival, fewer heart attacks or strokes, and i…

This study is checking how well a new drug-coated stent (Coroflex ISAR NEO) works in people with coronary artery disease. Researchers will follow 3,000 patients who get the stent during a routine procedure to see if it keeps arteries open safely. The goal is to confirm the stent …

This study tests an investigational drug called SRSD107 in people with chronic coronary artery disease or peripheral arterial disease. The goal is to see if it safely reduces a protein involved in blood clotting, which may lower the risk of dangerous clots. About 104 adults will …

This study tests a new way of caring for people with new-onset stable chest pain and suspected coronary artery disease. Instead of using a standard invasive heart catheterization, the new model uses a CT scan of the heart, which is less burdensome. The study will include about 3,…

This study tests whether doing a follow-up CT scan of the heart arteries in people with non-obstructive coronary artery disease can help doctors adjust treatment to better control cholesterol and prevent heart attacks, strokes, or death. About 3,100 participants will be randomly …

This study compares two treatments for people with completely blocked heart arteries (chronic total occlusions). One group gets a drug-coated balloon, with or without a stent; the other gets standard stents. The goal is to see if the balloon approach keeps arteries open just as w…

This study tests whether adding low-dose colchicine (0.5 mg daily) to standard heart treatments can lower the risk of major heart problems like heart attacks and strokes. About 3,800 adults with stable coronary artery disease and non-flow-limiting plaque will be randomly assigned…

This study tests two methods to fix a common problem: a heart stent that hasn't opened fully (underexpansion). One method uses a balloon to push the stent open, the other uses shock waves (lithotripsy) to crack the blockage. About 80 people with narrowed stents will be randomly a…

This study is tracking 508 patients with multivessel coronary artery disease who received the SUPRAFLEX CRUZ stent during routine care. Researchers are monitoring for heart-related events like heart attacks, repeat procedures, and heart function over 12 months. The goal is to con…

This registry study is testing a new AI tool called Heartflow PCI Navigator that creates a 3D model of a patient's heart arteries. Doctors use it to plan where to place stents to open blocked arteries. The study will enroll 5,000 people with coronary artery disease who are schedu…

This phase 3 trial tests whether an injection called XTR004, used with a PET scan, can accurately detect blood flow-blocking narrowings in heart arteries. About 395 adults with known or suspected stable coronary artery disease will receive the injection and undergo imaging. The r…

This study tests whether an artificial intelligence (AI) algorithm can screen for coronary artery disease (CAD) by analyzing facial images. Researchers will enroll 1,392 high-risk adults (those with diabetes, high blood pressure, or over 65) and use the AI to classify them as hig…

This study tests if fexuprazan can prevent upper stomach bleeding in 400 heart patients at high risk for bleeding who must take two blood thinners after getting a heart stent. Participants receive either fexuprazan or the standard drug lansoprazole daily for 6 months. The goal is…

This study tests whether combining progressive muscle relaxation and guided imagery can lower stress, anxiety, and depression in people with stable coronary artery disease. Forty adults will be split into two groups: one gets eight sessions of these mind-body techniques over four…

This study tests whether myofascial release, a gentle hands-on therapy, can help people recover after heart surgery that splits the breastbone. Fifty adults with heart disease will receive either standard physical therapy or standard therapy plus seven daily sessions of myofascia…

This study looks at 60 people with stable angina who have two blocked heart arteries. During a procedure, doctors will temporarily inflate a tiny balloon inside each stent to reduce blood flow while the patient exercises on a bike. The goal is to measure exactly how much flow red…

This observational study will enroll 10,000 adults who are already scheduled for a cardiac CT scan. Researchers will use artificial intelligence to analyze the scans, looking for subtle signs of dangerous plaque that might predict future heart attacks. Participants will also give…

This study is a registry that will enroll 816 adults with coronary artery disease. It compares two types of heart scans—CCTA and OCT—to see which one better identifies dangerous plaque and helps doctors plan treatment. The goal is to improve diagnosis and long-term outcomes, not …

This study involves over 12,000 Chinese patients with coronary heart disease who take blood thinners. The goal is to find new biological markers that can better predict who is at risk for dangerous blood clots or major bleeding. Researchers will combine genetic, protein, and imag…

This study compares two drug combinations (ketamine-lidocaine vs ketamine-fentanyl) used to put patients to sleep before heart bypass surgery. The goal is to see which combination better maintains blood flow to the brain during the procedure. The study includes 40 adults with cor…

This study follows 100 men aged 30-75 who had a heart procedure called PCI (stent placement) to open blocked arteries. Researchers want to see how erectile function changes over 6 months, comparing those who had a heart attack to those with stable chest pain. Participants fill ou…

This study is testing a new way to measure blood flow in the heart's arteries using ultrasound, without needing special wires or drugs. Researchers will follow about 500 people with coronary artery disease for one year to see if this measurement can predict serious heart events l…

This study is looking at whether data from a Fitbit smartwatch (like heart rate, sleep, and steps) can help assess heart health and predict the risk of heart disease. Researchers will track 100 adults over time, comparing their wearable data with standard heart health measures. T…

This study is for adults with a blocked radial artery who need a heart procedure like angiography or angioplasty. Doctors will use the ulnar artery in the same wrist instead. The goal is to see if this approach is safe and how it affects hand strength, feeling, and daily use. Res…

This study looks at how people with coronary artery disease (CAD) respond to arm versus leg exercise. Researchers will measure blood vessel stiffness, muscle oxygen levels, and energy use during both types of exercise. The goal is to better understand exercise limitations in CAD …

This study tests whether adjusting a patient's body position during heart bypass surgery can reduce the need for a blood pressure drug called noradrenaline. It involves 50 adults having their first planned or emergency bypass surgery. The goal is to find a simpler way to manage b…

People with type 2 diabetes are at high risk for heart disease. This study will follow 1,000 such patients who have already had a heart CT scan. Researchers will repeat the scan and track how plaque buildup in the heart's arteries changes over time. The goal is to better understa…