CLEAR CELL RENAL CELL CARCINOMA

This large, late-stage trial is comparing two different drug combination strategies to control advanced kidney cancer that has spread. It involves over 1,100 patients with intermediate or high-risk disease. The study aims to see if adding a drug called cabozantinib to a standard …

This study is testing a drug called adavosertib in people with advanced solid tumors that have spread and have a specific genetic change called SETD2-deficiency. The goal is to see if the drug can shrink or stop the growth of these tumors by blocking enzymes the cancer cells need…

This study is testing if taking the drug axitinib before surgery can shrink complex kidney tumors, making a kidney-sparing operation possible for patients who otherwise couldn't have it. The goal is to see if this approach is safe and helps surgeons successfully remove tumors whi…

This study tested whether taking a drug called pazopanib for about a year could help keep kidney cancer from returning after surgeons had successfully removed all visible tumors that had spread. Patients who had no signs of cancer left after surgery were randomly assigned to take…

This early-stage study is testing a new two-part radioactive drug for people with advanced kidney cancer that has spread. First, a low-dose version is used for imaging to see where tumors are. Then, a higher-dose version is given as a treatment to try to control the cancer. The m…

This study is testing if a new under-the-skin injection of the cancer drug nivolumab works as well as the standard intravenous (IV) version for people with advanced kidney cancer that has spread or returned after prior treatment. It involves about 681 participants and aims to see…

This study is testing whether a flexible, 'adaptive' dosing schedule for a two-drug combination is a practical approach to treat advanced kidney cancer. It will involve about 75 adults with a specific type of kidney cancer who have not yet received any treatment for their advance…

This study tested a new combination of two drugs, entinostat and aldesleukin, for patients with advanced kidney cancer that has spread. The goal was to find a safe dose and see if the combination could help control the cancer better than one drug alone. It involved 47 patients an…

This early-stage study is testing the safety and best doses of a combination of cancer drugs for people with advanced cancers of the urinary system (like bladder and kidney cancer) that have spread. The trial combines a pill (cabozantinib) that aims to block tumor growth with one…

This study is testing a combination of two drugs, pazopanib and bevacizumab, for people with advanced kidney cancer that has spread. The main goals are to find the safest and most effective dose and to see how well the treatment works to control the cancer and stop it from gettin…

This early-stage study is testing if adding a natural berry supplement called camu camu makes standard immunotherapy drugs work better for people with advanced kidney cancer that has spread. The main goal is to check if the combination is safe and to find the right dose of camu c…

This study is testing whether adding an experimental immune-boosting drug (PF-04518600) to a standard cancer drug (axitinib) works better than the standard drug alone for people with advanced kidney cancer that has spread. The goal is to see if the combination can better control …

This study is testing whether adding a selenium supplement (Seleno-L Methionine) to two standard cancer drugs (axitinib and pembrolizumab) is safe and more effective for treating advanced kidney cancer. It will involve about 55 adults with a specific type of kidney cancer that ha…

This early-stage study is testing three different immunotherapy drug combinations in patients with advanced kidney cancer that has spread. The main goal is to see which combination is safest and causes the fewest side effects when given before surgery to remove the cancer. Resear…

This study is testing if taking the drug cabozantinib for 12 weeks before surgery can shrink advanced kidney tumors that have not spread. The goal is to see if this pre-surgery treatment helps control the cancer and makes surgery more effective. Researchers will measure tumor shr…

This study is for people with advanced kidney cancer that has spread to their bones. It tests if adding a radioactive drug (radium-223) to a standard cancer pill (cabozantinib) works better than the pill alone. The main goal is to see if the combination can delay bone-related pro…

This study is testing whether combining a targeted radiation drug (177Lu-girentuximab) with an immunotherapy drug (nivolumab) is safe and effective for treating advanced kidney cancer that has a specific protein (CAIX). It is for adults with clear cell kidney cancer that has spre…

This study aimed to test a new type of imaging scan (piflufolastat F 18 PET/CT) to see if it could accurately find cancer that had spread from the kidney. It planned to enroll adults with clear cell kidney cancer who were suspected of having or were at high risk for the cancer sp…

This study aims to find new chemical markers in the blood and urine that could help detect kidney and bladder cancers. Researchers are collecting samples from 589 people, including those with these cancers and healthy individuals, to compare and identify reliable markers. The goa…