AORTIC DISSECTION

This study compares two surgical methods for repairing a torn aorta, a life-threatening emergency. Half of the 72 participants will receive standard surgery, while the other half will also get a special stent designed to reduce the risk of future tears and aneurysms. The goal is …

This study is testing a device that replaces both a faulty heart valve and a damaged section of the main artery (aorta) in one surgery. About 260 people worldwide will receive the Abbott Valved Graft. Researchers will track how many patients survive and whether they need another …

This study tests whether the anti-inflammatory drug ketorolac can improve outcomes for 360 people undergoing emergency surgery for a severe aortic tear (Stanford Type A aortic dissection). Participants receive either ketorolac or a placebo before and after surgery, alongside stan…

This study tests a new implant made of shape memory polymer to treat aortic dissection, a serious condition where the aorta wall tears. The implant is placed in the false lumen (the abnormal channel created by the tear) to block blood flow and prevent the aorta from growing. Abou…

This study tests whether specially modified grafts can safely repair complex aortic aneurysms in patients who are too high-risk for standard surgery. About 220 participants with abdominal or thoracoabdominal aneurysms or aortic dissections will receive a physician-modified endova…

This study tests a new device called the NEXUS stent graft to treat serious problems in the main artery near the heart, such as tears or bulges. About 110 adults will receive the stent through a small tube in a blood vessel, avoiding major open surgery. The goal is to see if the …

This study tests a new device that combines a stent and surgical graft to repair the main artery (aorta) in the chest. It is for people with aortic aneurysms, dissections, or birth defects. The goal is to see if the device is safe and works well, with follow-up for up to 2 years.

This study tests three custom-designed stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce hospital stays, lung problems, and death. About 410 participants will be enrolled at one center.

This study tests a new device called the GORE ascending stent graft to treat a sudden tear in the main artery from the heart (Type A aortic dissection). About 112 people with this emergency condition will receive the stent graft through a tube in an artery, avoiding open-heart su…

This study compares two surgical techniques for repairing a torn aorta (aortic dissection) in 50 adults. Participants are randomly assigned to receive either a hemiarch or extended arch repair. Researchers will track survival and whether additional procedures are needed over 3 ye…

This study aims to create a checklist of simple clinical signs that can identify blunt trauma patients who do not need a CT scan of their abdomen or pelvis. By studying 12,000 patients, researchers hope to find a set of criteria that is 98% accurate in ruling out serious injuries…

This study is collecting health information from 5,000 people who have a genetic condition that can cause the aorta (the main artery from the heart) to weaken or tear. Researchers want to learn how different gene changes affect the disease and what other factors might make it bet…

This study aims to create a large collection of medical information, DNA, blood, and tissue samples from 15,000 people with and without heart conditions. Researchers will use this biobank to better understand diseases like aortic aneurysm, heart failure, and bicuspid aortic valve…