AORTIC DISSECTION

This phase 3 trial tests whether the anti-inflammatory drug ketorolac can improve outcomes in 360 people undergoing emergency surgery for a life-threatening aortic dissection. Participants receive either ketorolac or a placebo before and after surgery, alongside standard care. Re…

This study tests a new device called the GORE ascending stent graft to treat a serious tear in the main artery from the heart (Type A aortic dissection). About 112 people with a recent tear will receive the stent graft through a small tube in a blood vessel, avoiding open-heart s…

This study is testing a device called a valved graft, which replaces both the aortic valve and the ascending aorta in one surgery. It includes 260 people with aortic valve disease, an enlarged aorta, or aortic dissection. The goal is to see how safe and effective the device is by…

This study tests a special stent graft that doctors modify by hand to treat complex aortic aneurysms and dissections in patients who are too high-risk for standard surgery or devices. About 220 participants will be followed for up to 5 years to see if the procedure is safe and ef…

This study tests a new device made of shape memory polymer to treat a complication of aortic dissection called false lumen. The goal is to block blood flow into the false lumen and prevent the aorta from growing larger, which can be dangerous. About 30 adults with type A or B aor…

This study tests three custom-made stents for people with complex aortic aneurysms that standard devices can't treat. The goal is to see if these stents reduce deaths, lung problems, and hospital stays. About 410 adults with certain types of aortic aneurysms will take part.

This study tests a new device called the NEXUS aortic arch stent graft system in 110 adults with serious conditions like aortic dissection or aneurysm affecting the aortic arch. The goal is to see if it is safe and effective at repairing the damaged area without major complicatio…

This study tests a new surgical technique called B-SAFER for people with complex aortic disease affecting multiple segments of the aorta. The procedure combines open surgery with a modified stent graft to repair the aortic arch and descending aorta in one operation. Researchers a…

This study compares two surgical methods for repairing a torn aorta, a life-threatening emergency. Half of the 72 participants will receive standard surgery, and the other half will also get a special stent designed to reduce the risk of future tears and the need for more operati…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study is gathering 5,000 people with certain gene changes that raise the risk of aortic disease (like aneurysms or dissections). Researchers will track their health over time to see how these genes affect the condition. The goal is to better predict and manage the disease, n…

This study is developing a decision tool to help doctors identify blunt trauma patients who can safely skip abdominal-pelvic CT scans, avoiding unnecessary radiation and expense. Researchers will collect data from 12,000 patients in the emergency department to find a set of clini…

This trial is testing two different surgical methods for repairing a torn aorta (aortic dissection). It will enroll 50 adults who need emergency surgery. The goal is to see which technique leads to fewer deaths and fewer repeat procedures over 3 years. The study is currently recr…