AGE-RELATED MACULAR DEGENERATION

This study tests a new medicine called tiespectus (EYE201) against the standard treatment aflibercept for wet age-related macular degeneration, a leading cause of vision loss. About 960 people with untreated wet AMD will receive eye injections and be followed for one year to comp…

This study looks at how well a biosimilar drug called Yesafili (MY-1701P) works for people with wet age-related macular degeneration (AMD), a condition that causes vision loss. Researchers will track 54 patients to see if the drug improves vision and reduces fluid buildup in the …

This study tests whether taking krill oil supplements daily for 3 months can reduce drusen (fatty deposits) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil or a placebo. The goal is to see if kri…

This study tests a device that delivers tiny electrical pulses to the eye area for people with intermediate to advanced dry age-related macular degeneration (AMD). About 100 participants will receive either the real treatment or a sham (fake) treatment over 11 months. The goal is…

This study tests a new medicine called ABBV-6628 for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 66 adults aged 50 and older will receive injections into the eye, either with the new drug or an approved t…

This study tests the safety of a monthly eye injection called ASP3021 in 20 Japanese adults aged 40 and older who have geographic atrophy, an advanced form of age-related macular degeneration that causes vision loss. Participants receive injections into the affected eye for 12 mo…

This study tests a new drug called VOY-101 in 60 people aged 60 and older with advanced dry age-related macular degeneration (AMD), a condition that causes blind spots. The goal is to see if VOY-101 can slow the growth of these spots and preserve vision. The study starts with sma…

This early-stage study tests a stem cell therapy called ASP7317 in 42 older adults with advanced dry age-related macular degeneration (geographic atrophy). The treatment is injected under the retina to replace damaged cells. Participants must take immune-suppressing drugs for a s…

This study tests a personalized treat-and-extend schedule for faricimab in 50 people newly diagnosed with polypoidal choroidal vasculopathy (PCV), a type of wet age-related macular degeneration. The goal is to see if this approach can keep the disease under control while allowing…

This study tests a new medicine called tiespectus (EYE201) against the standard treatment aflibercept for wet age-related macular degeneration (AMD), a leading cause of vision loss. About 960 adults with untreated wet AMD will receive injections into the eye to see if tiespectus …

This study tests a new way to detect age-related macular degeneration (AMD) before it causes vision loss. Researchers will use special structured light patterns, originally developed for quantum science, to see how well the eye perceives them. The goal is to catch AMD earlier tha…

This study tests whether teaching people with age-related macular degeneration, diabetic retinopathy, or glaucoma simple strategies—like using brighter lights, larger print, or smartphone apps—can help them manage their medications more safely and independently. About 50 particip…

This study tests a small telescope implant (SING IMT) for people with advanced age-related macular degeneration (AMD) who have lost central vision. About 76 adults aged 55 and older will receive the implant in one eye and be followed for 12 months. The goal is to see if the devic…

This study tests a way to help people with central vision loss from age-related macular degeneration read more easily. Researchers will move missing text to a different part of the visual field and measure reading speed and errors. About 108 participants will take part, including…

This early study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve eyesight in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study invo…

This observational study aims to define a new concept called 'visual frailty' in people aged 60 and older with advanced age-related macular degeneration (AMD). Researchers will measure vision, reading ability, mental health, and daily function to see how these factors relate. The…

This study aims to understand why 20-40% of people with wet age-related macular degeneration (AMD) do not respond well to standard anti-VEGF injections. Researchers will collect fluid from inside the eye of 117 patients and compare those who respond well to those who don't. The g…

This study looks at whether taking a daily supplement of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. Researchers will compare people who take the supplement to those who take a placebo. The goal is t…

This study tests whether measuring how quickly your eyes adjust to the dark can serve as an early sign that high-dose atorvastatin is working for intermediate age-related macular degeneration (AMD). About 21 participants will take the statin and undergo regular dark adaptation te…

This study collects blood, tissue, and health information from 650 people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to build a database and biobank for future research, not to provide treatment. Participants will…

This study will collect eye images from 1000 people aged 50 and older, both with healthy eyes and with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality dataset that researchers can use to develop artificial intelligence (AI) to…

This study watches how early-stage dry age-related macular degeneration (AMD) changes over time in 125 people aged 50 and older. Researchers use special eye scans to measure the growth of damaged areas and how vision and quality of life are affected. The goal is to better underst…