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New eye drug tiespectus takes on aflibercept in major wet AMD trial

NCT ID NCT07440225

Disease control Sponsor: EyeBiotech Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 03, 2026 · Updated 10 times

Summary

This study tests a new medicine called tiespectus (EYE201) for wet age-related macular degeneration, a leading cause of vision loss. About 960 people will receive either tiespectus or the standard treatment aflibercept via eye injections. The goal is to see if tiespectus can improve or maintain eyesight as well as the current drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 960 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The main inclusion criteria include but are not limited to the following: * Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye) * The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment The main exclusion criteria include but are not limited to the following * Has uncontrolled blood pressure at screening * History of any prior macular laser photocoagulation in the study eye * History of uveitis in either eye * History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study * Has uncontrolled glaucoma in the study eye * Active retinal disease other than the condition under investigation in the study eye * Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

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Conditions

The condition(s) this trial relates to.

age-related macular degeneration choroidal neovascularization macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Age related macular degeneration Choroidal neovascularization Macular degeneration Wet macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    117 sites in 12 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Associated Vitreoretinal and Uveitis Consultants

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Augenzentrum am St. Franziskus Hospital Münster

    RECRUITING

    Münster, 48145, Germany

  • Austin Research Center for Retina

    RECRUITING

    Austin, Texas, 78705, United States

  • Austin Retina Associates (Site 012)

    RECRUITING

    Austin, Texas, 78705, United States

  • Barzilai Medical Center

    RECRUITING

    Ashkelon, 7830604, Israel

  • Carmel Medical Center (Site 704)

    RECRUITING

    Haifa, 3436212, Israel

  • Centro Oftalmologico Dr Charles y Asociados (Site 300)

    RECRUITING

    Buenos Aires, C1121ABB, Argentina

  • Centro Oftalmologico Metropolitano

    RECRUITING

    San Juan, 00921, Puerto Rico

  • Centro Oftalmológico Dr. Zas

    RECRUITING

    Buenos Aires, PC1023, Argentina

  • Centro Privado de Ojos Romagosa SA (Site 307)

    RECRUITING

    Córdoba, X5000AAI, Argentina

  • Centro de Ojos Loria SRL (Site 312)

    RECRUITING

    Buenos Aires, CP1832, Argentina

  • Centro de Ojos Quilmes

    RECRUITING

    Buenos Aires, B1878KDF, Argentina

  • Centro de la Visión

    RECRUITING

    Salta, A4400, Argentina

  • Centro de la Visión (Site 309)

    RECRUITING

    Salta, A4400, Argentina

  • Centrovision Clinica Oftalmologica

    RECRUITING

    Mendoza, 5500, Argentina

  • Charles Retina Institute

    RECRUITING

    Germantown, Tennessee, 38138, United States

  • Charleston Neuroscience Institute (CNI) d/b/a Retina Consultants of South Carolina

    RECRUITING

    Mt. Pleasant, South Carolina, 29464, United States

  • Charleston Neuroscience Institute (Site 104)

    RECRUITING

    Charleston, South Carolina, 29414, United States

  • Charleston Neuroscience Institute - Bluffton (Site 124)

    RECRUITING

    Bluffton, South Carolina, 29910, United States

  • Cincinnati Eye Institute (Site 133)

    RECRUITING

    Cincinnati, Ohio, 45242, United States

  • Clinica Privada de Ojos

    RECRUITING

    Buenos Aires, B7600, Argentina

  • Clinica de Oftalmologia Barraquer

    RECRUITING

    Barcelona, 08021, Spain

  • Cumberland Valley Retina Consultants (Site 007)

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Eye Clinic Albury Wodonga (Site 425)

    RECRUITING

    Albury, 2640 NSW, Australia

  • Eye Clinic of Wisconsin

    RECRUITING

    Wausau, Wisconsin, 54403, United States

  • EyeHealth Northwest

    RECRUITING

    Portland, Oregon, 97225, United States

  • Florida Eye Clinic (Site 130)

    RECRUITING

    Altamonte Springs, Florida, 32701, United States

  • Florida Retina Consultants

    RECRUITING

    Lakeland, Florida, 33805, United States

  • Florida Retina Institute

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Fondation Asile des aveugles (Hôpital Ophtalmique Jules-Gonin)

    RECRUITING

    Lausanne, CH-1004, Switzerland

  • Fort Lauderdale Eye Institute (Site 042)

    RECRUITING

    Plantation, Florida, 33324, United States

  • Foundation for Vision Research (Site 073)

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • Fundacion Jorge Zambrano para la investigación, diagnostivo y tratamiento de enfermedades oculares (Site 302)

    RECRUITING

    Buenos Aires, C1023AAQ, Argentina

  • Global Research Management, Inc.

    RECRUITING

    Glendale, California, 91204, United States

  • Grupo Laser Vision (Rosario Eximer Laser Vision SA)

    RECRUITING

    Rosario, Santa Fe Province, S2000DLA, Argentina

  • Hadassah Medical Center Opthalmology Department (Site 701)

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hospital Britanico- Microcentro

    RECRUITING

    Cdad. Autónoma de Buenos Aires, 1008, Argentina

  • Hospital Universitari Vall d'Hebron - despacho de coordinación de oftalmología. Planta 8, Edifici General

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Puerta de Hierro - Majadahonda

    RECRUITING

    Madrid, 28222, Spain

  • Illinois Retina Associates

    RECRUITING

    Oak Park, Illinois, 60304, United States

  • Instituto Donato

    RECRUITING

    Cdad. Autónoma de Buenos Aires, C1428, Argentina

  • Instituto Oftalmologico de Buenos Aires SA (Site 306)

    RECRUITING

    Buenos Aires, C1120AAN, Argentina

  • Instituto Zeman Bardeci (Site 311)

    RECRUITING

    Salta, A4400, Argentina

  • Instituto de Microcirugía Ocular Córdoba (IMOC S.R.L) (Site 305)

    RECRUITING

    Córdoba, 5000, Argentina

  • Kaplan Medical Center Ophthalmology Department (Site 705)

    RECRUITING

    Rehovot, 7661005, Israel

  • Klinika okulistyczna w Olsztynie - Centrum Diagnostyki i Mikrochirurgii Oka Lens

    RECRUITING

    Olsztyn, 10-424, Poland

  • Launceston Eye Doctors

    RECRUITING

    Launceston, 7250, Australia

  • London North West University Healthcare NHS Trust (LNWH) (Site 201)

    RECRUITING

    London, NW10 7NS, United Kingdom

  • Marsden Eye Specialists (Site 420)

    RECRUITING

    Parramatta, 2150, NSW, Australia

  • Marsden Eye Specialists (Site 423)

    RECRUITING

    Strathfield, 2135 NSW, Australia

  • Microcirugia Ocular Rosario (Site 310)

    RECRUITING

    Rosario, Santa Fe Province, S2000TC, Argentina

  • Mid Atlantic Retina

    RECRUITING

    Cherry Hill, New Jersey, 08034, United States

  • Mid Atlantic Retina (Site 050)

    RECRUITING

    Bethlehem, Pennsylvania, 18017, United States

  • Midwest Eye Institute

    RECRUITING

    Carmel, Indiana, 46032, United States

  • Mississippi Retina Associates (Site 084)

    RECRUITING

    Madison, Mississippi, 39110, United States

  • North Carolina Retina Associates

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • Northern Kurzeme Regional Hospital

    RECRUITING

    Ventspils, LV3601, Latvia

  • Oftalmika Sp. z o.o.

    RECRUITING

    Bydgoszcz, 85-631, Poland

  • Oftalmología Global (Centro Médico Oftalmología Global) (Site 304)

    RECRUITING

    Rosario, Santa Fe Province, S2000DSK, Argentina

  • Oftar Centro De Oftalmología en Mendoza

    RECRUITING

    Mendoza, 5500, Argentina

  • P.Stradins clinical university hospital

    RECRUITING

    Riga, LV1002, Latvia

  • Pacific Northwest Retina (Site 112)

    RECRUITING

    Burlington, Washington, 98233, United States

  • Palmetto Retina Center

    RECRUITING

    Aiken, South Carolina, 29803, United States

  • Piedmont Eye Center (Site 054)

    RECRUITING

    Lynchburg, Virginia, 24502, United States

  • Piedmont Retina Specialists - Greensboro

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Piedmont Retina Specialists - Winston-Salem

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • RSresearch (Site 308)

    RECRUITING

    Buenos Aires, C1033AAW, Argentina

  • Rabin Medical Center (Site 700)

    RECRUITING

    Petah Tikva, 49100, Israel

  • Rambam Health Corporation (Site 706)

    RECRUITING

    Haifa, 3109601, Israel

  • Research Network Arizona / Retina Macula Institute of Arizona

    RECRUITING

    Scottsdale, Arizona, 85255, United States

  • Retina & Vitreous of Texas

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Retina Associates of Florida, LLC

    RECRUITING

    Tampa, Florida, 33609, United States

  • Retina Associates of Utah

    RECRUITING

    Salt Lake City, Utah, 84107, United States

  • Retina Care Specialists

    RECRUITING

    Palm Beach Gardens, Florida, 33410, United States

  • Retina Center of Arkansas

    RECRUITING

    Fayetteville, Arkansas, 72703, United States

  • Retina Center of Texas

    RECRUITING

    Southlake, Texas, 76092, United States

  • Retina Consultants of Minnesota

    RECRUITING

    Saint Louis Park, Minnesota, 55416, United States

  • Retina Consultants of Southern California (Site 043)

    RECRUITING

    Redlands, California, 92374, United States

  • Retina Consultants of Texas (Site 014)

    RECRUITING

    The Woodlands, Texas, 77384, United States

  • Retina Consultants, PLLC

    RECRUITING

    Charleston, West Virginia, 25301, United States

  • Retina Group of Florida (Site 070)

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • Retina Northwest, PC

    RECRUITING

    Portland, Oregon, 97221, United States

  • Retina Partners of Northwest Arkansas, PLLC

    RECRUITING

    Springdale, Arkansas, 72764, United States

  • Retina Research Institute of Texas (Site 010)

    RECRUITING

    Abilene, Texas, 79606, United States

  • Retina Specialists of Mississippi

    RECRUITING

    Hattiesburg, Mississippi, 39402, United States

  • Retina Vitreous Associates of Florida

    RECRUITING

    Tampa, Florida, 33617, United States

  • Retina Vitreous Associates of Florida (Site 049)

    RECRUITING

    St. Petersburg, Florida, 33711, United States

  • Retina Vitreous Center

    RECRUITING

    Edmond, Oklahoma, 73013, United States

  • Retina Vitreous Surgeons of CNY, PC (Site 033)

    RECRUITING

    Liverpool, New York, 13088, United States

  • Retina and Eye Consultants

    RECRUITING

    Hurstville, 2220, Australia

  • Retinal Consultants Medical Group (Site 020)

    RECRUITING

    Sacramento, California, 95825, United States

  • Retinal Consultants Medical Group (Site 022)

    RECRUITING

    Sacramento, California, 95841, United States

  • Retinal Consultants Medical Group (Site 024)

    RECRUITING

    Modesto, California, 95356, United States

  • Riga East University hospital, clinical centre Bikernieki

    RECRUITING

    Riga, LV1006, Latvia

  • Shamir Medical Center (Site 703)

    RECRUITING

    Ẕerifin, 7033001, Israel

  • Sheba Medical Center (Site 707)

    RECRUITING

    Ramat Gan, 6265601, Israel

  • Silmalaser OÜ

    RECRUITING

    Tallinn, 11412, Estonia

  • Southern Vitreoretinal Associates

    RECRUITING

    Tallahassee, Florida, 32308, United States

  • Southwest Retina Specialists

    RECRUITING

    Amarillo, Texas, 79106, United States

  • Spokane Eye Clinical Research (Site 075)

    RECRUITING

    Spokane, Washington, 99204, United States

  • Springfield Clinic

    RECRUITING

    Springfield, Illinois, 62703, United States

  • Stadtspital Zurich Triemli Forschungszentrum Augenklinik

    RECRUITING

    Zurich, CH-8063, Switzerland

  • Strategic Clinical Research Group

    RECRUITING

    Weatherford, Texas, 76087, United States

  • Swiss Eye Institute and Berner Augenklinik

    RECRUITING

    Bern, CH-3007, Switzerland

  • Sydney Eye Hospital (Site 426)

    RECRUITING

    Sydney, 2000 NSW, Australia

  • Sydney Retina Clinic and Day Surgery (Site 424)

    RECRUITING

    Sydney, 2000, NSW, Australia

  • Texas Retina (Site 037)

    RECRUITING

    Plano, Texas, 75075, United States

  • Texas Retina Associates

    RECRUITING

    Arlington, Texas, 76012, United States

  • Texas Retina Associates

    RECRUITING

    Dallas, Texas, 75231, United States

  • Tulsa Retina Consultants

    RECRUITING

    Tulsa, Oklahoma, 74114, United States

  • University Hospital Basel, Eye Clinic

    RECRUITING

    Basel, CH-4031, Switzerland

  • University Hospitals of Leicester NHS Trust (Site 209)

    RECRUITING

    Leicester, LE1 5WW, United Kingdom

  • Vision Research Center Eye Associates of New Mexico

    RECRUITING

    Albuquerque, New Mexico, 87109, United States

  • Vista Augenklinik Binningen

    RECRUITING

    Binnigen, CH-4102, Switzerland

  • Vitreo Retinal Associates

    RECRUITING

    Gainesville, Florida, 32607, United States

  • Wildwood Clinical Research / Florida Retina Institute

    RECRUITING

    Wildwood, Florida, 34785, United States

  • ong Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY (Site 105)

    RECRUITING

    Hauppauge, New York, 11788, United States

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