AGE-RELATED MACULAR DEGENERATION

This study looks at the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. It includes 278 adults aged 50 and older who already completed a previous study …

This study tested an experimental drug called ALK-001 in people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. About 200 participants received the drug and 100 received a placebo. The goal was to see if ALK-001 could slo…

This study tested whether the antibiotic minocycline, taken as a pill twice daily for three years, could safely slow the growth of geographic atrophy (an advanced form of dry age-related macular degeneration) and preserve vision. Thirty-seven adults aged 55 and older with geograp…

This study tested a drug normally used for Parkinson's disease (carbidopa-levodopa) in 35 people with wet age-related macular degeneration (AMD). The goal was to see if adding this pill to standard eye injections could improve vision and reduce the number of injections needed. Th…

This study tested a robotic arm that holds a tiny needle steady during eye surgery. 20 people with bleeding behind the retina (from age-related macular degeneration) received a clot-busting drug injected under the retina using the robot. The goal was to see if the robot could hel…

This study tested a drug normally used for Parkinson's disease (carbidopa-levodopa) in 20 people with wet age-related macular degeneration (AMD). The goal was to see if it is safe and can improve vision or reduce retinal swelling. Participants had not received standard anti-VEGF …

This study tested two different schedules of the eye injection brolucizumab in 52 adults with wet age-related macular degeneration (AMD) whose vision was not fully controlled by previous treatment. The goal was to see which dosing plan works better and is safer over 52 weeks. Par…

This study tested whether regular eye injections of a drug called aflibercept could prevent the 'wet' form of age-related macular degeneration (AMD) in people already at high risk. 128 participants with early signs of AMD in one eye and wet AMD in the other eye were randomly assi…

This study tested whether a steroid eye drop called loteprednol can reduce pain after eye injections for age-related macular degeneration. 64 people who already get these injections received either loteprednol or artificial tears after one visit. Their pain was tracked over a wee…

This study looked at 100 people with age-related macular degeneration (AMD) to measure proteins in their eye fluid. The goal was to understand why about 37% of patients do not respond well to standard anti-VEGF injections. By measuring these proteins, researchers hope to find clu…

This study looked at two different scanning methods to monitor wet age-related macular degeneration (AMD) in 68 adults aged 50 and older who were already receiving anti-VEGF injections as needed. The goal was to see if using a newer type of scan (OCT angiography) instead of the s…

This study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to build a database. The goal was to find imaging markers that can predict if and when the disease will progress to a more advanced stage with vision loss. Researchers will …

This study followed people aged 55 and older with early age-related macular degeneration (AMD) or a related condition called reticular pseudodrusen (RPD), along with healthy volunteers. Researchers used eye exams, imaging, and vision tests to track changes over up to 5 years. The…

This study looked at whether giving people with age-related macular degeneration (AMD) personalized risk information, including genetic testing, along with coaching, helps them make healthier lifestyle changes. 150 participants with early or intermediate AMD were involved. The go…

This study looked at whether telling healthy people their genetic risk for age-related macular degeneration (AMD) would encourage them to eat more carotenoid-rich foods, which are good for eye health. Researchers measured skin and eye carotenoid levels in 80 Caucasian adults aged…

This study looked at how vision gets worse over time in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers used past medical records and eye scans from 60 patients to see which changes in the retina are linked to faster vision lo…

This study looked at 556 people to understand why some with early age-related macular degeneration (AMD) have trouble seeing in the dark. Researchers used advanced eye imaging to map how changes in the retina affect night vision recovery. The goal was to find better ways to measu…

This study looked at 470 people with age-related macular degeneration (AMD) to see if special eye scans (SDOCT) could predict vision loss and disease worsening. Participants were at moderate to high risk for progression. The goal was to find early signs of damage that could help …

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…