ACUTE DECOMPENSATED HEART FAILURE

This study looks at whether people hospitalized for acute heart failure can safely drink as much as they want instead of limiting fluids. About 420 participants will be randomly assigned to either a strict 1.5 liters per day limit or a thirst-driven liberal intake. Researchers wi…

This study tests whether using urine sodium levels to adjust diuretic doses helps people with acute heart failure recover faster and live longer. About 556 adults hospitalized with acute heart failure will receive either standard care or a tailored diuretic plan. The goal is to s…

This phase 3 trial studies whether patients with acute decompensated heart failure who are already taking an SGLT2 inhibitor like empagliflozin should continue it during hospitalization. About 536 participants will either keep taking empagliflozin or switch to a placebo while in …

This trial tests whether doing a coronary angiogram (a special X-ray of the heart arteries) within 2 hours of diagnosis is better than waiting until the patient's heart failure symptoms improve. The study includes 780 adults with a type of heart attack called NSTEMI who also have…

This study tests whether using a simple bedside ultrasound to measure fluid levels can help doctors give the right amount of medication to heart failure patients. The goal is to reduce hospital readmissions within 30 days and prevent kidney damage. About 588 adults hospitalized w…

This study tests a device called the eLym System that drains excess fluid from the lymphatic system to treat congestion in people hospitalized with acute decompensated heart failure. The device is placed temporarily for up to 60 hours in a heart catheterization lab. Researchers a…

This Phase 3 trial tests the Reprieve System, a bedside device that automatically adjusts diuretic and saline infusion based on a patient's urine output, to treat acute decompensated heart failure. Researchers will compare it to standard diuretic therapy in 400 hospitalized adult…

This study tests two water pills—acetazolamide and metolazone—added to standard diuretics in 320 adults hospitalized with acute decompensated heart failure. The goal is to see which drug clears fluid buildup faster and more safely, reducing hospital stays and complications. Parti…

This study tests whether adjusting the dose of a diuretic (water pill) based on urine sodium levels can improve outcomes for people hospitalized with acute heart failure. Researchers will compare two urine sodium targets against standard care in 600 adults. The goal is to see if …

This pilot study tests the Reprieve System, a bedside device that automatically adjusts the delivery of a diuretic (furosemide) and saline based on the patient's real-time urine output. The goal is to safely and quickly remove excess fluid from 50 hospitalized adults with acute d…

This study tests three different drugs—empagliflozin, acetazolamide, and metolazone—added to standard water pills (loop diuretics) in 66 adults hospitalized for acute decompensated heart failure. The goal is to see which drug works best at increasing urine output over three days.…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This study looks at whether a special heart failure care network can help people who were recently in the hospital for worsening heart failure. About 1000 adults with moderate to severe heart failure will take part at five heart centers in Germany. Half will get extra support fro…

This study is testing whether using a blood test called NTproBNP can help doctors decide the best time to discharge patients hospitalized with worsening heart failure. 750 participants will be randomly assigned to either a biomarker-guided discharge plan or usual care. The goal i…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at whether early heart ultrasound results can predict which patients hospitalized with heart failure will need to return to the hospital or have a higher risk of death. Researchers will measure heart structure and function before starting IV diuretics in 76 adult…