Stroke disorder

This study tested the WATCHMAN device, a small implant that closes off a part of the heart where clots often form, in 481 people with atrial fibrillation who cannot take blood thinners. The goal was to see if the device is safe and effective at reducing stroke risk. Participants …

This trial tests whether a 6-month telehealth program can reduce stroke risk factors, especially high blood pressure, in people already at elevated risk. Participants receive personalized remote care including blood pressure monitoring, wearable tracking, and virtual visits with …

This study tested whether injections of MYOBLOC (botulinum toxin type B) can safely reduce muscle tightness in the arm and hand of adults with spasticity caused by stroke, brain injury, multiple sclerosis, or other conditions. The trial planned to enroll about 300 participants bu…

This study looked at whether taking high doses of statins for two weeks before carotid artery surgery could prevent memory and thinking problems after the operation. It included 31 adults with severe carotid artery narrowing. The study was stopped early, so the results are limite…

This study tested whether checking blood clotting levels every week with a small finger-prick device is better than the usual monthly lab test for elderly nursing home residents on blood thinners. The goal was to see which method keeps patients in the safe therapeutic range longe…

This study aimed to see if the antibiotic minocycline could improve outcomes after a stroke. Participants were to receive either standard care plus minocycline pills for five days, or standard care alone. However, the trial was stopped early after enrolling only 2 people, so no m…

This study tested a smartphone-based program to help stroke survivors with high blood pressure lower their risk of another stroke. The program involved tracking blood pressure and getting tailored reminders. The study was terminated early, so results are limited.

This study looked at whether a procedure to remove large blood clots from the brain could help people who had a severe stroke. It included 335 adults with a large stroke who could be treated within 7 hours. The goal was to see if the procedure reduced disability compared to stand…

This study tested whether giving lithium carbonate before carotid artery surgery could reduce brain damage and confusion after the operation. The trial planned to include 107 adults undergoing elective carotid surgery, but it was terminated early. The goal was to see if lithium c…

This study will check if an artificial intelligence (AI) tool can help less experienced doctors read MRI scans of stroke patients as accurately as a brain scan specialist. About 500 adults who are being evaluated for a stroke will have their MRI results compared. The goal is to s…

This study tested whether a cone beam CT scan, done right after a stroke procedure called thrombectomy, could tell the difference between a brain hemorrhage and harmless contrast dye buildup. Only 5 adults were enrolled before the study was stopped early. The goal was to see if t…

This study tested a wearable device that sits on the neck to detect swallowing problems in people with conditions like stroke, Parkinson's, multiple sclerosis, Alzheimer's, or dementia. The device was compared to a standard X-ray test. Unfortunately, the device did not meet the a…

This trial tests different settings of a gentle electrical stimulation device, placed on the skin of the affected arm, to see which ones best improve hand function in people who have had a stroke. Participants will receive varying durations and strengths of stimulation, and resea…

This study looked at whether practicing walking while doing other tasks (multitasking) helps people recovering from a stroke walk faster than just walking practice alone. It included 26 adults who had a stroke within the past 6 months and had trouble walking. The trial was stoppe…

This study observed 18 chronic stroke patients who received botulinum toxin injections into their elbow muscles as part of routine care. The goal was to see if the injections reduced muscle tightness (spasticity) and improved active arm extension. Researchers measured muscle acti…

This study tested whether MYOBLOC, a botulinum toxin injection, can safely reduce muscle stiffness in the lower leg of adults with spasticity caused by stroke, brain injury, or spinal cord injury. About 40 participants received either a low or high dose of MYOBLOC or a placebo in…

This study tested a brace called CALIGALOC designed to correct foot drop (ankle varus) in people with hemiparesis after a stroke or other brain injury. The goal was to see if wearing the brace for 15 days improved walking speed and balance. Only 5 people took part, and the study …

This small pilot study tested whether combining a gentle brain stimulation technique (tDCS) with a thinking-strategies training program could help people who had a stroke more than six months ago perform everyday activities better. Eleven participants were enrolled to see if the …

This study tested a wearable device that uses gentle vibrations to help stroke survivors improve arm strength and movement. The plan was to have 48 people use the device at home for 4 weeks, but only 4 enrolled before the study was stopped. Researchers measured usability and chan…

This study looked at whether a cortisone injection into the shoulder joint, combined with physiotherapy, reduces pain and improves movement in people who had a stroke and developed shoulder pain. It included 50 adults in a rehab program. The study was stopped early, so results ar…

This study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …

This study tested whether a magnetic device (rTMS) placed on the scalp could help people who had a stroke regain movement in their arm. The trial planned to include 60 adults with recent ischemic stroke. However, the study was terminated early, so the results are not complete.

This study tested a personalized walking and balance training program using a KineAssist robotic treadmill for people recovering from traumatic brain injury, stroke, or other acquired brain injuries. The goal was to safely challenge and improve walking speed, balance, strength, a…

This study looked at whether adding functional electrical stimulation (FES) to robotic hand therapy could improve arm movement in people who had a stroke within the past year. Researchers planned to compare two groups: one getting standard rehab plus robotic therapy and FES, and …

This study tested whether adding safe balance challenges (called perturbations) to body-weight supported walking therapy helps stroke survivors improve their balance and walking more than standard therapy alone. Participants were adults in inpatient rehab after a stroke. They use…

This study tested a program called PROPEL that combines group aerobic exercise with weekly self-management discussions for people recovering from a stroke. The goal was to see if this approach helps participants stay physically active for six months after leaving rehabilitation. …

This study tested whether reactive balance training—exercises that involve sudden pushes, pulls, or quick movements—can improve aerobic fitness and leg strength in people who had a stroke at least six months ago. The researchers expected that this training would be as good as sta…

This study tested whether a gentle electrical current applied to the scalp (tDCS) during speech therapy could help stroke survivors with aphasia name objects better. Only 5 people took part, and the study was stopped early, so the results are not reliable enough to draw conclusio…

People who have a stroke face a much higher risk of heart problems in the following weeks, but researchers do not fully understand why. This study uses PET/MRI scans of the heart and blood tests for inflammatory markers to see whether inflammation develops in the heart after a st…

Researchers at the University of Pennsylvania are studying how people with stroke, upper limb amputation, spinal cord injury, or cerebral palsy move their arms during common daily activities like drinking and pouring. The study uses two passive desktop robots to track the motion …

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. Over half of right-stroke patients have trouble with prosody, which can affect social interactions and quality of life. Researchers will test 150 participants…

This study looks at people who had a stroke or mini-stroke with no known cause (cryptogenic stroke). Researchers want to see if a small device implanted under the skin, called an implantable loop recorder, can detect hidden atrial fibrillation — an irregular heart rhythm that can…

This study aimed to identify brain areas outside the main motor region that help arm recovery after a severe stroke. Researchers followed 28 patients over time, using MRI and movement tracking to see which brain areas became active as arm function improved. The goal was to find n…

This study tested whether a small implanted device that stimulates the vagus nerve could improve arm and hand function in people who had a stroke at least a year ago. Four participants received either real or sham stimulation paired with physical therapy. The goal was to see how …

This study looked at how stroke changes the brain's ability to recognize emotions like fear and happiness. Researchers used MRI and EEG to compare stroke patients with healthy volunteers. The study was stopped early and only included 2 participants, so findings are very limited.

This study tested whether a single session of magnetic brain stimulation (called rTMS) over a specific brain area could improve pointing movements in people who had a stroke. Only one person took part, and the study was stopped early. The goal was to see if the stimulation could …

This study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …

This study aimed to see if a blood test measuring platelet function could predict neurological events like stroke in people undergoing carotid artery surgery. Researchers planned to enroll 650 patients but the study was terminated early. The test uses a device called Multiplate t…

This observational study aimed to understand how stroke affects walking during early recovery. Researchers used motion analysis and brain stimulation to track changes in 6 participants over 6 months. The study was terminated early, so findings are limited.

This study aimed to monitor muscle strength and body composition changes in the first 10 days after a severe stroke. Researchers used a device called an impedancemeter to measure muscle mass and a dynamometer to test grip strength. Only 6 people participated before the study was …

This study looked at whether using a condom catheter instead of a standard indwelling urinary catheter (IUC) lowers the chance of delirium in men aged 70+ who had a stroke. Delirium is a sudden confused state that can happen after a stroke. The trial planned to compare two groups…

This study looked at whether having a family member work closely with hospital staff could improve recovery for stroke survivors with spatial neglect—a condition where people ignore one side of their world. The study planned to include more people but was stopped early, so only 1…

This study tested a new questionnaire called the Brain Injury Self-Efficacy Scale to see how well it measures a person's confidence in managing challenges after a brain injury. Researchers compared it with other standard self-efficacy scales. The study involved 150 adults with a …

This pilot study aimed to see if antiseizure drugs like phenobarbital and levetiracetam change brain connectivity patterns in people with severe acute brain injury and reduced consciousness. Only 5 participants were enrolled before the study was terminated. Researchers used resti…

This study aimed to compare two common sedatives, propofol and midazolam, in patients with traumatic brain injury who needed a breathing tube. Researchers wanted to see if one drug led to better recovery or different levels of inflammation markers called cytokines. However, the t…