Puerperal disorder

This pilot study looks at two strategies to help pregnant and postpartum people with substance use disorder stay in treatment. One strategy screens for social needs like housing or childcare and connects patients to support. The other offers rewards for recovery-supportive behavi…

This study tests whether washing the wound with a low-dose chlorhexidine solution after a C-section helps prevent infections and improves healing compared to standard saline. The trial will include 400 women at higher risk for complications, such as those with obesity or diabetes…

This study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery will be randomly assigned to receive either factor XIII plus standard care or standard care a…

This phase 3 trial is testing whether adding a single dose of azithromycin to standard antibiotics can prevent infections in 8,000 women having scheduled C-sections. Participants receive either azithromycin or a placebo, plus usual care. The study tracks infections like wound inf…

This study compares two telehealth programs designed to help new mothers get faster care after childbirth, especially those with low income. About 3,500 women will receive either virtual education with reminders or a more interactive telehealth model. The goal is to see which app…

This study tests whether giving monthly cash payments to pregnant women with HIV in Botswana helps them better manage their health. Researchers want to see if the money improves their ability to stick to HIV medication and stay in care after giving birth. About 100 women will tak…

This study compares two common blood pressure medications, Nifedipine and Labetalol, to see which works better and is safer for women who develop high blood pressure after giving birth. About 500 new mothers will be randomly assigned to one of the two drugs. The goal is to reduce…

This study tests whether tiny particles from stem cells, called exosomes, can repair blood vessel damage in women who had preeclampsia during pregnancy. Preeclampsia raises the risk of heart disease later in life, and current treatments don't fully heal the blood vessels. The tri…

This study is testing a new test called the Enlighten Device that uses a blood or saliva sample to predict if a pregnant woman will develop postpartum depression (PPD) after giving birth. Researchers will enroll 1,000 pregnant women and follow them for three months after delivery…

This study looks at whether giving blood thinners (LMWH) for 6 weeks after childbirth can prevent dangerous blood clots in women who have a moderate risk. About 2,400 women will be randomly assigned to receive either the blood thinner or standard care without it. The goal is to s…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon red…

This study is testing whether giving new mothers a low-dose blood thinner for just 7-10 days after delivery can prevent blood clots in the legs or lungs. About 9,200 women with certain risk factors (like emergency C-section, obesity, or pre-eclampsia) will either receive the drug…

This study tests whether a single 20-minute session of radiofrequency diathermy (a type of heat therapy) can improve pain sensitivity, heat perception, and tissue elasticity in postpartum women with and without abdominal muscle separation (diastasis recti). 48 women will receive …

This study compares two types of core exercises—hypopressive training and transversus abdominis focused training—to see which better reduces urinary incontinence and improves pelvic floor function and quality of life in women after childbirth. Sixty women who had a normal vaginal…

This study looks at whether a supervised weekly exercise program can help new mothers (up to 24 months after giving birth) increase their physical activity, improve muscle strength, and reduce common postpartum issues like pelvic floor problems and fear of movement. About 50 wome…

This study looks at whether adding a gentle manual therapy called Mulligan mobilization to standard core exercises can reduce pain and improve movement in new mothers with sacroiliac joint dysfunction. About 48 women, 6 weeks to 6 months after childbirth, will receive either core…

This study compares two types of shoulder exercises—scapular posterior tilt exercises and cross-body stretching—to see which better improves breastfeeding efficiency, latch quality, and posture in postpartum women with rounded shoulders. Thirty-four women who have had a C-section…

This study tests whether adding stability-oriented breathing exercises to standard Kegel exercises can help postpartum women reduce pain, close the abdominal gap (diastasis recti), and strengthen their core. Sixty women who had a C-section and are 6-7 weeks postpartum will be spl…

This study tests whether 8 weeks of diaphragmatic breathing or pelvic stabilization exercises, done at home via video calls, can reduce pain and disability in 60 postpartum women with pregnancy-related pelvic girdle pain. Participants will also receive pelvic anatomy education. T…

This study tests a mobile app called BumptUp to see if it helps pregnant and postpartum women in rural areas become more physically active. About 176 women will either use the app or receive an educational brochure. Researchers will track activity levels, weight, diet, blood pres…

This study tests a virtual platform called MOVIN that helps pregnant and postpartum people with depression or anxiety. Participants get a care coordinator who recommends online treatments and works with their doctor. The goal is to see if this approach reduces symptoms better tha…

This study tests whether a visual education tool can help new mothers recognize and report urgent warning signs after childbirth, such as deep vein thrombosis. Forty postpartum women will view pictures of complications and then answer questions to see if they understand and would…

This study follows 380 women for a year after vaginal delivery to see how pelvic floor muscles and tissues recover. It also tests whether early, personalized pelvic floor exercises can improve symptoms like urine leakage and pelvic organ prolapse compared to standard care. Partic…

This study aims to create a new scoring system (SOFA-OBS) that better predicts death risk for pregnant and postpartum women in intensive care. Researchers will collect routine data from 130 patients and test if a simple pulse oximeter can replace painful blood draws. The goal is …

This online registry is studying the safety and effectiveness of the CEFALY device, a non-invasive nerve stimulator worn on the forehead, for treating migraines during and after pregnancy. Pregnant women aged 18-44 with migraines can join, regardless of whether they use the devic…

This study in France tests whether having the national health insurance pay for vaccines during outpatient visits increases how many people get vaccinated. Researchers will compare vaccination rates for pneumococcal infections and whooping cough (pertussis) before and after the f…

This study compares standard postpartum care to a technology-based program called H.E.A.R. for Mamas, which uses text messages and phone calls to screen new mothers for complications. About 2,900 Medicaid-insured women in South Carolina will take part. The goal is to see if this …

This study looks at how long new mothers with high blood pressure should monitor their blood pressure from home after giving birth. Researchers will compare a 2-week program to a 6-week program to see which leads to better health outcomes. About 400 women who have already joined …

This study looks at two common ways doctors stitch the uterus after a C-section: using one layer of stitches or two. The goal is to see which method leads to a thicker, healthier scar and fewer problems like pain or bleeding later on. About 100 women having a C-section will be ra…

This study tests how easy and useful a new digital program called Hope-D is for managing weight during pregnancy and for 6 months after giving birth. The program includes a digital pathway, weight management plans, and coaching. 30 pregnant women with a BMI of 30 or higher will u…

This study is testing whether a smartphone app can help new mothers in Pennsylvania with postpartum education, symptom tracking, and parenting support. Sixty women who recently gave birth will use the app for 8 weeks and answer surveys about how easy it is to use and whether it m…

This study is for first-time mothers having a vaginal birth. It aims to see if the length of time the baby's head is crowning (visible at the vaginal opening) is linked to a tear in a key pelvic muscle. Researchers will use ultrasound after birth to check for muscle injury and as…