Preterm premature rupture of the membranes

This trial investigates whether using a lab test (IL-6) from amniotic fluid to guide antibiotic and steroid treatment can safely prolong pregnancy in people whose water breaks too early (preterm premature rupture of membranes, or pPROM). Participants are randomly assigned to eith…

This study looks at two common methods to start labor in pregnant women whose water breaks before labor begins (term PROM) and whose cervix is not yet ready. One group gets a vaginal insert (dinoprostone) to soften the cervix, followed by oxytocin if needed. The other group gets …

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants wil…

This study tests whether adding azithromycin to the standard antibiotic ampicillin can reduce serious health problems in newborns when a mother's water breaks early (between 34 and 37 weeks). About 311 women with a single pregnancy will receive either ampicillin alone or ampicill…

This study tests whether watching nature-themed videos through virtual reality glasses can reduce anxiety and distress in pregnant women hospitalized with premature rupture of membranes. 176 women will either receive standard care or watch calming nature videos twice a day for th…

This study tests whether giving the drug papaverine through an IV can help women whose water has broken (but labor hasn't started yet) deliver faster. About 110 pregnant women at term will receive either papaverine or a placebo 12 hours after their water breaks. The goal is to se…

About 1 in 4 women have their water break before labour starts. Most go into labour within 48 hours, but some need to be induced. This study tests whether deliberately breaking the leftover membrane when a woman is admitted to the hospital can shorten the time to labour and reduc…

This study is a patient registry for women diagnosed with Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy. Researchers will collect data from 3,000 participants to identify possible causes, evaluate care trends, and review short- and long-term outcomes…

This study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…

This study looks at 86 pregnant women whose water breaks early (before 37 weeks). It compares two ways doctors check the cervix: a traditional speculum exam and a digital exam using fingers. The goal is to see if digital exams affect how long the pregnancy lasts before delivery. …

This study tests whether pregnant women with complications like pre-eclampsia or fetal growth restriction can use a remote device at home to monitor their baby's heart rate. Sixty participants between 32 and 37 weeks of pregnancy will try the device daily. Researchers will check …