Cure My Disease

Don't miss your cure!

 Log in / Sign up

Personalized treatment for early water breaking could extend pregnancy safely

NCT ID NCT07107477

Recruiting now Disease control Sponsor: The Central and Eastern European Gynecologic Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether using a lab test (IL-6) from amniotic fluid to guide antibiotic and steroid treatment can safely prolong pregnancy in people whose water breaks too early (preterm premature rupture of membranes, or pPROM). Participants are randomly assigned to either standard care or a tailored approach where weekly amniocentesis measures IL-6 levels to decide when to give steroids and antibiotics. The study aims to see if this personalized strategy helps the pregnancy last more than 7 days after pPROM and improves outcomes for both parent and baby.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
amniocentesis-guided tailored antibiotic and steroid therapy
What this could lead to
If successful, this approach could help doctors time treatments better, reduce unnecessary medication, and safely extend pregnancy after early water breaking.
What could go wrong
This is a Phase 3 trial with 138 participants, so results may not apply to all. Amniocentesis carries small risks like infection or cramping, and the tailored strategy may not improve outcomes over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

preterm premature rupture of the membranes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRETERM PREMATURE RUPTURE OF MEMBRANES (PPROM)

Contacts and locations

Locations

  • General University Hospital in Prague

    RECRUITING

    Prague, 128 08, Czechia

  • Institute for Mother and Child Care in Prague - Podolí

    RECRUITING

    Prague, Czechia

    Contact Email: •••••@•••••

  • University Hospital Brno

    RECRUITING

    Brno, Czechia

More trials for these conditions

Other studies related to the condition(s) this trial covers.