Could a simple IV drug shorten labor after water breaks?
NCT ID NCT07517796
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving the drug papaverine through an IV can help women whose water has broken (but labor hasn't started yet) deliver faster. About 110 pregnant women at term will receive either papaverine or a placebo 12 hours after their water breaks. The goal is to see if the drug reduces the time from water breaking to delivery and improves outcomes for both mother and baby.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- papaverine
- What this could lead to
- If it works, this could offer a simple, low-cost way to shorten labor after water breaks at term, potentially reducing infection risk and the need for cesarean delivery.
- What could go wrong
- This is a small, early-phase trial with only 110 participants, so results may not apply widely. Papaverine may not speed up labor more than placebo, and there is a risk of side effects like low blood pressure or allergic reactions.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Galilee Medical Center
RECRUITINGNahariya, Israel, Israel
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