Preterm premature rupture of the membranes

This study tested two antibiotics, azithromycin and erythromycin, in 250 pregnant women whose water broke too early (between 28 and 34 weeks). The goal was to see which drug better prevents infection in the mother and improves newborn health. Participants took one of the two anti…

This study looked at 88 pregnant women whose water broke before labor started, comparing those who got labor-inducing gel right away versus those who waited 24 hours. The goal was to see which approach led to shorter labor and more vaginal deliveries. The findings could help guid…

This study tested whether a daily capsule of cranberry, hibiscus, vitamin C, and lactobacillus could lengthen the time between a pregnant woman's waters breaking early (between 24 and 34 weeks) and delivery. 84 women were randomly assigned to receive either the supplement or a pl…

This pilot study tested whether giving two medications (mifepristone and misoprostol) at the same time helps women deliver faster after a nonviable second-trimester pregnancy, compared to misoprostol alone. Thirty women between 14 and 28 weeks pregnant who needed labor induction …

This study tested whether giving a steroid (dexamethasone) before inducing labor can help women deliver faster after their water breaks. Sixty first-time mothers with full-term pregnancies and ruptured membranes received either the steroid or a placebo. Researchers measured the t…

This study looked at whether two sessions of hypnosis could lower anxiety in pregnant women with preterm premature rupture of membranes (PPROM). 60 women took part, with some receiving hypnosis and others standard care. The goal was to see if hypnosis helps reduce anxiety and imp…

This study looked at a protein called osteopontin in the blood of pregnant women whose water broke too early (PPROM). Researchers compared 71 women with early rupture to those with normal-term rupture to see if protein levels differ. The goal was to learn more about the biology b…

This completed study looked at 36 pregnant women to understand why the membranes around the baby break too early (PPROM). Researchers measured certain proteins called syndecans in the mother's blood and in the placenta and amniotic membrane after birth. The goal was to find clues…