Preterm premature rupture of the membranes

This study tests two common antibiotics—erythromycin and azithromycin—in pregnant people whose water breaks too early (before 34 weeks). Both are given along with standard antibiotics. The goal is to see which combination helps delay delivery longer, giving the baby more time to …

This study tests whether giving nifedipine, a drug that relaxes the uterus, for 48 hours can improve health outcomes for babies when a pregnant person's water breaks too early (between 22 and 34 weeks). About 857 participants will receive either nifedipine or a placebo. The goal …

This study aimed to see if giving antibiotics to pregnant people whose water broke very early (before 22 weeks) could delay delivery and improve baby health. It was planned for those with a single baby and recent membrane rupture. However, the study was withdrawn before enrolling…

This study watches a single gynecology resident as they learn to perform a hysterectomy through the vagina using a special camera, leaving no belly scars. The goal is to see how quickly the resident improves, measuring surgery time and any complications. Nineteen women with benig…

This study is testing whether women with high-risk pregnancies can be safely monitored from home instead of staying in the hospital. Researchers will check if home monitoring is practical, safe, and costs less, while also improving patients' quality of life. About 250 pregnant wo…

This study is creating a biobank—a collection of blood samples and health data—to help researchers better understand gynecological disorders, infertility in men and women, and pregnancy-related conditions. Up to 3,000 participants will provide samples at San Raffaele Hospital in …