Periapical periodontitis

This study tests two different medicines placed inside root canals to kill bacteria in teeth with chronic infection. 24 adults with infected molars will receive either a bioceramic or a calcium hydroxide paste. Researchers measure bacterial levels before and after treatment to se…

This study compares two methods for disinfecting root canals in teeth with apical periodontitis (an infection at the tooth root). Fifty adults with infected molars will receive either a laser-based disinfection or a standard protocol. The goal is to see which method reduces bacte…

This study compares three different root canal dressings used between visits in retreatment cases. The goal is to see which one best reduces inflammation, shrinks infection-related lesions, and lowers pain. Sixty adults with previously treated but still infected lower first molar…

This study compares two medications placed inside the tooth after a failed root canal: standard calcium hydroxide and the painkiller diclofenac sodium. Sixty patients with persistent infection around the tooth root will be randomly assigned to one of the two treatments. Healing w…

This study tests whether a diode laser, apple cider vinegar, or the herb Gymnema Sylvestre can better disinfect root canals in people with type 2 diabetes who have a tooth infection called apical periodontitis. Ninety participants will be split into groups receiving different com…

This study tests whether two nano-sized pastes—nano-calcium hydroxide and nano-chitosan—can reduce inflammation and pain in people who need a second root canal treatment. The trial will enroll 63 adults with a single-rooted tooth that has a persistent infection and no current pai…

This study compares standard root canal retreatment with a regenerative method using injectable platelet-rich fibrin (i-PRF) in 140 adults with persistent tooth infections. Participants are randomly assigned to one of the two treatments and followed for two years to assess healin…

This study tests whether using an 810 nm diode laser during root canal retreatment helps the bone around the tooth heal better. Forty adults with a failed root canal and a visible infection will receive standard retreatment plus either laser disinfection or a calcium hydroxide pa…

This study aims to see if a special MRI designed for teeth can diagnose jaw joint disorders, tooth infections, and help plan dental implants as well as or better than traditional X-rays. About 470 adults needing dental imaging will get both an MRI and standard X-rays, and the res…

This study compares two types of root canal sealers—NeoSEALER Flo and AH Plus—to see which one leads to less pain after treatment and better healing of the area around the tooth root. About 30 adults with infected tooth roots and no other health issues will take part. Pain is mea…

This trial tests two ways of activating cleaning solutions during a repeat root canal procedure to see if one leads to less pain and better healing. Adults with a failed root canal in a single-rooted tooth will be randomly assigned to receive either Xp Finisher R file activation …

This trial tests whether photobiomodulation (PBM), a type of low-level laser therapy, can reduce pain and improve healing after endodontic microsurgery—a procedure to treat infections at the tip of a tooth root. About 90 adults needing this surgery will receive either real PBM or…

This trial tests whether a custom 3D-printed surgical guide can improve the accuracy of apicoectomy—a procedure to remove the tip of a tooth root after a failed root canal. Participants will have the guided surgery and then report pain and swelling at 1, 3, and 7 days. At 6 month…

This study tests whether placing ibuprofen, nitrofurantoin, or calcium hydroxide inside a tooth after root canal treatment can lower pain. About 111 adults with dead nerves in their back teeth will rate their pain on a 0-10 scale. The goal is to find which medication works best t…

This study compares two different irrigation techniques used during root canal retreatment to see which one leads to less pain afterward. About 100 adults with a previous root canal and ongoing infection will take part. The goal is to find a simple way to improve comfort after th…

This study tests whether applying a special gel (cross-linked hyaluronic acid) during root-end surgery helps the gums heal faster and reduces pain afterward. About 46 adults with a tooth infection that didn't heal after standard root canal treatment will take part. Half will get …

This study tests a new way to do root canals that skips the manual step of scouting and widening the canal by hand. Instead, dentists use a special rotary file from the start. The goal is to see if this causes less pain after the procedure compared to the traditional method. The …

This study tests whether using a special laser to disinfect the root canal can lower inflammation and pain after a root canal has failed. Fifty-two adults with a failed root canal and a visible infection on X-ray will receive either standard cleaning plus the laser or standard cl…

This study surveys 100 French dentists who treat children to understand why they often choose extraction for non-vital baby teeth, even though effective alternatives like pulpectomy exist. The goal is to collect and analyze their treatment choices, reservations, and decision-maki…

This study tests whether artificial intelligence can predict if a less invasive procedure called full pulpotomy (removing only the infected pulp) will succeed in treating painful molars, compared to standard root canal treatment. Researchers will enroll 58 adults with irreversibl…

This study looks at whether root canal treatment can reduce inflammation markers linked to heart disease in people with stable coronary artery disease and infected tooth roots. Eighty adults will either get immediate root canal treatment or wait three months. Researchers will mea…