Palmoplantar pustulosis
MONDO:0015597A rare skin disease characterized by chronic eruption of sterile pustules on an erythematous and desquamative background, affecting the palms and soles, sometimes also the lateral aspects of hands and feet. The lesions are usually painful. Nail lesions (such as nail pitting, onycholysis, subungual pustules, and nail dystrophy) are also observed. The condition takes a chronic and relapsing course. Typical associations are psoriatic arthritis, thyroid gland dysfunction, and smoking.
Also known as: LPP, PPP, Palmoplantar Pustulosis, localised pustular psoriasis, localized pustular psoriasis, palmoplantar pustulosis, pustulosis of palm and sole, pustulosis palmaris et plantaris
22 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New cream shows promise for painful hand and foot pustules
Disease control Recruiting nowThis study tests a cream called delgocitinib for people with mild to severe palmoplantar pustulosis, a skin condition causing painful pus-filled blisters on hands and feet. About 135 adults will apply the cream twice daily for 16 weeks. The main goal is to see if the cream reduce…
Phase: PHASE2 • Sponsor: LEO Pharma • Aim: Disease control
Last updated Jul 23, 2026 00:00 UTC
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New hope for painful hand and foot pustules: phase 3 trial launches
Disease control Recruiting nowThis phase 3 trial tests whether the drug bimekizumab can clear or nearly clear the pustules and skin lesions of palmoplantar pustulosis (PPP) on the hands and feet. About 320 adults with moderate to severe PPP will receive either bimekizumab or a placebo for 16 weeks, with an op…
Phase: PHASE3 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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New drug picankibart aims to treat stubborn hand and foot pustules
Disease control Recruiting nowThis study tests a drug called picankibart in 60 adults with moderate-to-severe palmoplantar pustulosis, a painful skin condition causing pus-filled blisters on hands and feet. Participants receive injections of picankibart over nearly a year. The goal is to see if it reduces the…
Phase: NA • Sponsor: Xijing Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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New hope for painful hand and foot skin disease: experimental drug enters trial
Disease control Recruiting nowThis study tests a new biologic drug called Xeligekimab in 10 adults with moderate to severe palmoplantar pustulosis (PPP), a chronic skin disease causing painful blisters and scales on the palms and soles. The goal is to see if the drug can reduce symptoms and improve quality of…
Phase: PHASE4 • Sponsor: First Hospital of China Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New pill hopes to clear stubborn hand and foot blisters
Disease control Recruiting nowThis study tests a daily pill called ivarmacitinib for palmoplantar pustulosis (PPP), a chronic skin condition causing painful blisters on hands and feet. Sixty adults who haven't improved with other treatments will take the pill for 12 weeks. Researchers will check if symptoms l…
Phase: NA • Sponsor: Xijing Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Can a simple cream soothe psoriasis? new trial tests Urea-Based lotions
Symptom relief Recruiting nowThis study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…
Phase: NA • Sponsor: ICIM International S.r.l. • Aim: Symptom relief
Last updated Jul 30, 2026 00:00 UTC
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Scientists seek skin samples to unlock secrets of common rashes
Knowledge-focused Recruiting nowThis study collects skin samples from 500 people with conditions like acne, eczema, and psoriasis, as well as healthy volunteers. Researchers will analyze the samples to find biomarkers and gene patterns linked to inflammation. The goal is to better understand these skin diseases…
Sponsor: Innovaderm Research Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Psoriasis patients may face hidden heart dangers, new study aims to find out
Knowledge-focused Recruiting nowThis study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…
Sponsor: Herlev and Gentofte Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:09 UTC