Palmoplantar pustulosis
MONDO:0015597A rare skin disease characterized by chronic eruption of sterile pustules on an erythematous and desquamative background, affecting the palms and soles, sometimes also the lateral aspects of hands and feet. The lesions are usually painful. Nail lesions (such as nail pitting, onycholysis, subungual pustules, and nail dystrophy) are also observed. The condition takes a chronic and relapsing course. Typical associations are psoriatic arthritis, thyroid gland dysfunction, and smoking.
Also known as: LPP, PPP, Palmoplantar Pustulosis, localised pustular psoriasis, localized pustular psoriasis, palmoplantar pustulosis, pustulosis of palm and sole, pustulosis palmaris et plantaris
22 clinical trials for this condition and its sub-types.
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Can a pill clear psoriasis on hands and feet?
Disease control Not yet recruitingThis trial tests whether an oral medication called zasocitinib (TAK-279) can reduce the redness, thickening, scaling, and painful cracks of palmoplantar psoriasis, a type of psoriasis that affects the palms and soles. Adults with moderate-to-severe non-pustular palmoplantar psori…
Phase: PHASE3 • Sponsor: Takeda • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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New drug cocktail aims to clear stubborn hand and foot pustules
Disease control Not yet recruitingThis Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…
Phase: PHASE3 • Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Laser boost for stubborn psoriasis on hands and feet
Disease control Not yet recruitingThis study compares two treatments for palmoplantar psoriasis, a form of psoriasis affecting the palms and soles. One group receives a topical steroid cream alone, while the other receives the same cream plus a fractional CO2 laser treatment every four weeks. The goal is to see i…
Phase: PHASE4 • Sponsor: Cairo University • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC