Palmoplantar pustulosis
MONDO:0015597A rare skin disease characterized by chronic eruption of sterile pustules on an erythematous and desquamative background, affecting the palms and soles, sometimes also the lateral aspects of hands and feet. The lesions are usually painful. Nail lesions (such as nail pitting, onycholysis, subungual pustules, and nail dystrophy) are also observed. The condition takes a chronic and relapsing course. Typical associations are psoriatic arthritis, thyroid gland dysfunction, and smoking.
Also known as: LPP, PPP, Palmoplantar Pustulosis, localised pustular psoriasis, localized pustular psoriasis, palmoplantar pustulosis, pustulosis of palm and sole, pustulosis palmaris et plantaris
45 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New drug cocktail aims to clear stubborn hand and foot pustules
Disease control Not yet recruitingThis Phase 3 trial tests whether combining two drugs, tofacitinib and imatinib, can safely clear the painful pustules of palmoplantar pustulosis (PPP), a rare chronic skin disease on the palms and soles. About 135 adults with moderate-to-severe PPP will receive either the combo o…
Phase: PHASE3 • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Can a simple cream soothe psoriasis? new trial tests Urea-Based lotions
Symptom relief Not yet recruitingThis study tests two medical creams containing urea (20% and 40%) on people with mild plaque psoriasis or non-pustular palmoplantar psoriasis. Each participant applies the cream to one affected area and leaves a similar area untreated for comparison. The goal is to see if the cre…
Phase: NA • Sponsor: ICIM International S.r.l. • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Skin deep: european study probes the hidden emotional toll of skin diseases
Knowledge-focused Not yet recruitingThis study looks at how people with skin conditions (like eczema, psoriasis, or skin cancer) manage stress, feel lonely, and bounce back from challenges. Researchers will compare 375 adults with and without skin disease across 15 European countries using questionnaires. The goal …
Phase: NA • Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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30,000 blood samples could revolutionize rapid disease testing
Knowledge-focused Not yet recruitingThis study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…
Sponsor: LumiraDx UK Limited • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC