Palmoplantar pustulosis
MONDO:0015597A rare skin disease characterized by chronic eruption of sterile pustules on an erythematous and desquamative background, affecting the palms and soles, sometimes also the lateral aspects of hands and feet. The lesions are usually painful. Nail lesions (such as nail pitting, onycholysis, subungual pustules, and nail dystrophy) are also observed. The condition takes a chronic and relapsing course. Typical associations are psoriatic arthritis, thyroid gland dysfunction, and smoking.
Also known as: LPP, PPP, Palmoplantar Pustulosis, localised pustular psoriasis, localized pustular psoriasis, palmoplantar pustulosis, pustulosis of palm and sole, pustulosis palmaris et plantaris
22 clinical trials for this condition and its sub-types.
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New drug shows promise for painful hand and foot pustules
Disease control CompletedThis study tested four different doses of an experimental drug (BI 655130) against a placebo in 152 adults with moderate to severe palmoplantar pustulosis (PPP), a skin condition causing painful pus-filled blisters on the palms and soles. The main goal was to see which dose best …
Phase: PHASE2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug shows promise for painful hand and foot psoriasis
Disease control CompletedThis study tested a drug called spesolimab in 59 people with palmoplantar pustulosis (PPP), a painful skin condition causing pustules and plaques on the palms and soles. Participants received either low or high doses of spesolimab or a placebo for 12 weeks. The goal was to see if…
Phase: PHASE2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New drug aims to clear painful hand and foot pustules
Disease control CompletedThis phase 2 trial tested a monthly injection called imsidolimab (ANB019) in 59 adults with palmoplantar pustulosis, a chronic skin condition causing painful, pus-filled blisters on the palms and soles. The study compared the drug to a placebo to see if it could reduce the severi…
Phase: PHASE2 • Sponsor: Vanda Pharmaceuticals • Aim: Disease control
Last updated Jun 26, 2026 17:06 UTC
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AI boosts doctor accuracy for rare skin diseases in new study
Knowledge-focused CompletedThis study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…
Sponsor: AI Labs Group S.L • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Japanese registry sheds light on how palmoplantar pustulosis is treated
Knowledge-focused CompletedThis completed registry study in Japan looked at how doctors treat palmoplantar pustulosis (PPP), a skin condition causing pus-filled blisters on hands and feet. Researchers collected data from 276 patients' medical records and clinic visits to understand which treatments are use…
Sponsor: Janssen Pharmaceutical K.K. • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC