Palmoplantar pustulosis
MONDO:0015597A rare skin disease characterized by chronic eruption of sterile pustules on an erythematous and desquamative background, affecting the palms and soles, sometimes also the lateral aspects of hands and feet. The lesions are usually painful. Nail lesions (such as nail pitting, onycholysis, subungual pustules, and nail dystrophy) are also observed. The condition takes a chronic and relapsing course. Typical associations are psoriatic arthritis, thyroid gland dysfunction, and smoking.
Also known as: LPP, PPP, Palmoplantar Pustulosis, localised pustular psoriasis, localized pustular psoriasis, palmoplantar pustulosis, pustulosis of palm and sole, pustulosis palmaris et plantaris
22 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
-
New hope for tough psoriasis spots: tildrakizumab under the microscope
Disease control OngoingThis study looks at how well tildrakizumab works for psoriasis in areas that are often hard to treat, like the scalp, nails, genitals, and palms. About 120 adults with moderate to severe psoriasis will receive tildrakizumab and be followed for up to 52 weeks. The goal is to see i…
Sponsor: Clin4all • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
-
New imaging tricks could end guesswork for hand and foot skin conditions
Knowledge-focused OngoingThis study looked at 81 adults with either palmoplantar psoriasis or palmoplantar eczema, two skin conditions that can look very similar on the palms and soles. Researchers used two special camera techniques—polarized dermoscopy and ultraviolet-induced fluorescence dermoscopy—to …
Sponsor: Istanbul Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC