Orofacial cleft

This trial compares standard cleft palate surgery alone versus surgery augmented with platelet-rich fibrin (PRF) or gentamicin-loaded PRF in 90 children and adolescents with cleft palates. The goal is to see if these biological adjuncts improve wound healing, reduce wound breakdo…

This study tests whether a handheld device that strengthens the muscles used for breathing and swallowing can improve speech in children aged 5 to 17 with velopharyngeal dysfunction, a condition where the soft palate does not close properly, causing nasal-sounding speech. Partici…

This study compares two bone grafting techniques for people with cleft lip and palate. One method uses a lab-made bone material, while the other uses the patient's own hip bone. The goal is to see which approach is more cost-effective, causes less pain, and heals just as well. Ab…

This study tests a new 3D printed aligner for infants born with a complete cleft lip and palate. The device aims to make nasoalveolar molding (a treatment that reshapes the gums and nose before surgery) more accurate and easier to use. Twenty infants under 45 days old will receiv…

This study tests whether a quadratus lumborum block—a type of nerve block—can better control pain and reduce opioid use in children aged 6 to 18 who are having palate repair surgery with bone taken from the hip. Half of the participants receive the nerve block, while the other ha…

This study tests whether an opioid-free anesthesia approach using ketamine and dexmedetomidine can control pain and reduce agitation just as well as standard opioid anesthesia in 90 children aged 3 months to 7 years undergoing cleft lip or palate repair. Researchers will measure …

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study tests whether adding a pain medicine called Ketorolac to standard care helps children drink more fluids after cleft palate surgery. About 74 children with cleft palate (with or without cleft lip) will take part. The goal is to see if better pain control leads to improv…

This study compares three different sedatives (ketamine, nalbuphine, and dexmedetomidine) given to 60 children aged 6 months to 3 years who need stitches removed after cleft lip or palate surgery. The goal is to see which drug works fastest and safest to keep the child calm and c…

This study tests whether giving a numbing medicine (bupivacaine) as a mist before surgery can lower pain and the need for extra painkillers in children aged 1-7 having cleft palate repair. Half the children get the mist, half get a placebo, and neither the doctors nor families kn…

This study tests whether a custom 3D-printed mouth splint can help burn patients who have developed microstomia (a tight, small mouth opening). Ten participants will use the splint and be measured for changes in mouth size and function using a special survey. The goal is to ease …

This study looks back at medical records of 150 children who had cleft palate surgery. Some received standard pain relief with morphine, while others also got a maxillary nerve block. Researchers want to see if the nerve block group needed less morphine, had fewer side effects, a…

This study tests a custom 3D-printed silicone tray that covers the cleft during intubation (placing a breathing tube) in children with cleft lip and palate. The goal is to reduce injuries like bleeding or swelling and make the procedure safer. About 120 children will take part, a…

This study compares two ways to sedate children before cleft palate repair: a combination of two drugs (dexmedetomidine and ketamine) given through a nebulizer versus dexmedetomidine alone. The goal is to see which approach works better for calming the child before surgery and pr…

This study investigates why some children still have speech problems (velopharyngeal insufficiency) after cleft palate surgery. Researchers will use real-time MRI to look at how the soft palate moves and its muscle structure in children aged 7 to 12. By comparing children with di…

This study aims to find genetic factors that may cause cleft lip and palate. Researchers will analyze the DNA of 30 people with the condition using advanced sequencing. The goal is to better understand the genetic roots of this birth defect, which could inform future research.

This study aims to find genetic changes that cause orofacial clefts (like cleft lip and palate) but are missed by standard tests. Researchers will use a new, high-resolution DNA mapping method called optical genome mapping on 26 people with clefts who have no known genetic diagno…