Nidovirales infectious disease

This early-stage trial tests a new mRNA COVID-19 booster vaccine made by Bio-Manguinhos/Fiocruz. About 90 healthy adults aged 18-59 will receive one of three doses (25, 50, or 100 micrograms) to check safety and immune response. The study is not yet recruiting and will monitor pa…

This study tests a new COVID-19 vaccine (LUNAR-COV19) in 56 adults who received a blood stem cell transplant within the past year. These patients often have weaker immune responses to standard vaccines. The new vaccine uses a self-amplifying mRNA that may produce a stronger and l…

This Phase 3 trial tests whether dapagliflozin, a drug used for diabetes, can improve quality of life in people with long COVID. 192 adults with persistent symptoms for at least 12 weeks after a COVID infection will receive either the drug or a placebo daily for 12 months. The ma…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether giving a 7-day course of corticosteroids (like prednisolone) to hospitalized adults with severe respiratory infections and low oxygen levels can reduce deaths and the need for breathing machines. About 3,000 participants will be randomly assigned to recei…

This early-stage study tests a single dose of a new drug called AVM0703 in 16 adults with severe breathing failure (ARDS) caused by COVID-19 or the flu. The main goal is to check if the drug is safe and how the body processes it. Participants are randomly assigned to receive the …

This early-stage trial tests a new drug called B10-FC, which is a lab-made antibody designed to fight the SARS-CoV-2 virus. The study will first give the drug to 25 healthy volunteers in increasing doses to check safety, then to 10 COVID-19 patients. The main goal is to see if th…

This study will test a new at-home rapid test that checks for flu A, flu B, and COVID-19 using a nasal swab. About 200 people with symptoms will use the test themselves, and their results will be compared to standard lab PCR tests. The goal is to see if the test is accurate and e…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study will test a new at-home diagnostic test that aims to detect five respiratory viruses—COVID-19, influenza A and B, RSV, and rhinovirus—from a single nose swab. About 2,000 people with cold or flu symptoms will provide samples in simulated home environments. The test's a…

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This study tests two nasal protective devices (Noseguard and Noseguard Night) in 2000 adults to see if they can reduce the risk of catching respiratory infections like COVID-19 and influenza. Participants will use the devices as directed for 8 weeks, and researchers will track in…

This study tests whether a special fish oil (Omega Cold) can help healthy adults avoid or recover faster from colds, flu, and COVID-19. Four hundred participants aged 18–80 will take either the fish oil or a placebo daily for four months during flu season. They will report any sy…

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

This early-stage trial tests a single IV dose of placental stem cell vesicles (XoGlo Pro) against placebo in 64 adults with mild to moderate COVID-19. The main goal is safety, with a secondary focus on how quickly symptoms resolve. Researchers aim to see if these tiny cell partic…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

This study will test the safety of a new biologic drug called stapokibart, given as a shot, in 400 adults with seasonal allergic rhinitis (SAR). Participants are already prescribed the drug by their doctor. The main goal is to track any side effects. This is an open-label study, …

This phase 3 trial tests whether a single dose of baloxavir helps non-hospitalized adults with mild-to-moderate influenza recover faster compared to a placebo. About 264 participants will be enrolled within 5 days of symptoms and tracked until they feel fully recovered. The study…

This study tests whether virtual reality (VR) can help people cope with trauma from COVID-19. It involves 100 adults, including healthcare workers and COVID-19 survivors, who will try VR exposure therapy in 5 weekly sessions. The goal is to see if this approach reduces PTSD sympt…

This study tests whether a non-invasive device that gently stimulates nerves can help people with long COVID symptoms like muscle pain, breathing issues, and loss of taste or smell. About 104 adults who had COVID-19 and still have symptoms for at least 30 days will receive either…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study will analyze samples from 130 ICU patients with ARDS (a severe lung injury) to better understand why the condition varies so much between people. Researchers will examine lung fluid, blood, and CT scans to identify distinct biological subtypes. The goal is not to test …

This study will track which respiratory viruses—like flu, COVID-19, and RSV—are circulating in French primary care clinics each winter. Up to 25,000 patients with cold or flu symptoms will provide a saliva or nose swab sample. The goal is to monitor virus activity and help guide …

This study looks at 120 preterm infants born before 34 weeks to see if those born during the COVID-19 pandemic (2020-2021) develop differently than those born after (2023-2024). Researchers will test thinking, movement, and language skills using play-based assessments. The goal i…

This study uses a special PET scan to look for signs of inflammation in the brains of people with Post-COVID syndrome. Researchers want to learn more about why some people have long-lasting symptoms after a COVID-19 infection. Ten Mayo Clinic patients who had COVID-19 and are exp…

This study will give healthy, vaccinated adults aged 18-50 a dose of the Omicron EG.5.1 COVID-19 variant through nose drops to safely create a mild infection. Researchers aim to find the right dose that infects 50-70% of volunteers with few or no symptoms. Participants will stay …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study looks back at the medical records of 50 adult ICU patients with COVID-19 who needed a life-support machine called ECMO. The goal is to understand how often bleeding and dangerous blood clots happen, and how blood transfusions and blood thinners affect their care. The f…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study will test if a new health awareness video can teach public transportation drivers in Lebanon about preventing respiratory infections like colds and flu. About 160 drivers will be split into two groups: one watches the health video, the other watches a neutral video abo…

This study will use a non-invasive imaging method called electrical impedance tomography (EIT) to measure how air moves through the lungs of 50 people with ongoing symptoms after COVID-19. Researchers will compare EIT results with standard CT scans and lung function tests to see …

This study examines whether having COVID-19 increases the chance of lung inflammation (radiation pneumonitis) in breast cancer patients receiving radiation therapy. Researchers will review medical records of 200 patients to compare outcomes between those who had COVID-19 and thos…

This study will review medical records of 300 immunocompromised adults hospitalized with COVID-19 in France between June 2023 and April 2024. Researchers want to see how well antiviral drugs like nirmatrelvir/ritonavir and remdesivir work in these patients. The goal is to track t…