Neonatal sepsis

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This study will test a new biomarker called t6A to see if it can help doctors diagnose bacterial infections in newborn babies early. Researchers will measure t6A levels in 210 infants who need blood tests for suspected infection. The goal is to find a more accurate way to detect …

This study tests a new, non-invasive tool called the POP-Score to predict infection in newborns within the first 6 hours of life. The score combines light-based measurements of muscle oxygen with routine vital signs like heart rate and blood pressure. Researchers will enroll 93 n…

This trial tests whether adding a quick blood test for presepsin can safely reduce unnecessary antibiotic use in very preterm infants. Currently, over 85% of these babies get antibiotics right after birth, but only 1 in 70 actually has an infection. The study will enroll 900 infa…

This study is testing whether a set of blood markers can accurately rule out late-onset sepsis in newborns in intensive care. Researchers will enroll 358 babies with signs of infection and compare the markers against a panel of experts. If the markers work well, doctors could avo…

This study tests whether increasing kangaroo care (skin-to-skin contact) in neonatal intensive care units can reduce severe infections and antibiotic-resistant bacteria in very premature infants (born before 32 weeks). Over 3,000 babies across multiple hospitals will be involved.…

This study compares two common hand rubs—chlorhexidine and alcohol—used by medical staff before touching premature babies in the NICU. The goal is to see which one better prevents healthcare-associated infections. One hundred premature infants will be monitored with blood culture…

This study looks at whether preterm infants in the NICU can safely stop taking the antibiotic ampicillin after 24 to 36 hours instead of the usual 48 hours. Researchers will measure drug levels in the blood and monitor the babies for any problems. The goal is to see if a shorter …

This trial tests whether button-sized wireless sensors can accurately measure heart rate, oxygen levels, and skin temperature in extremely preterm infants in the NICU. The sensors aim to replace bulky wired monitors that can stress fragile babies. Ten stable preterm infants will …

This study looks back at medical records of 60 critically ill adults in an intensive care unit who received a blood-cleaning treatment called hemoadsorption. The goal is to see if the therapy helps lower the need for drugs that raise blood pressure, improves lab results, and affe…

This study looks at how to help hospital units reduce the use of vancomycin, an antibiotic, in preterm infants. Researchers will compare two approaches to implementing new guidelines across 13 NICUs. The goal is to see which method works better at safely lowering antibiotic use.

This study will roll out three proven antibiotic stewardship strategies in Dutch hospitals to see if they reduce unnecessary antibiotic use in newborns with suspected early-onset sepsis. Researchers will compare data from before and after the strategies are put in place, involvin…

This study collects amniotic fluid from 275 pregnant women delivering at various stages, including extremely preterm. Researchers will analyze the fluid's microbes and chemicals, and link them to the baby's gut bacteria and health outcomes like necrotizing enterocolitis (NEC) and…