Neonatal sepsis

This study looks at whether a higher dose of dexamethasone, a steroid given to pregnant women at risk of early birth, helps preterm babies' lungs mature better. Researchers are comparing babies born between 26 and 36 weeks whose mothers received either 12 mg or 6 mg of dexamethas…

This study looked at whether giving vitamin D alongside antibiotics helps premature babies with sepsis recover better. Researchers gave 78 preterm infants either antibiotics alone or antibiotics plus 400 or 800 IU of vitamin D daily for 7 days. They tracked changes in sepsis scor…

This study looked at whether giving antibiotics for a shorter, personalized time is as safe and effective as the usual 7-day course for full-term newborns with a suspected infection. About 488 babies took part across 18 hospitals. The goal was to see if shorter treatment could re…

This study tested whether giving probiotics (single or multiple strains) to 249 premature babies for 28 days after birth could prevent necrotizing enterocolitis, sepsis, and improve growth. The babies were born before 36 weeks and weighed under 2500 grams. Researchers compared a …

This study looked at 60 very preterm or low birth weight babies to see which type of connector used on their central line (a special IV) works better to prevent serious bloodstream infections. Researchers compared a split septum connector to a mechanical valve connector. They tra…

This study tested whether measuring a blood marker called procalcitonin (PCT) could help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 newborns were included, and the goal was to reduce antibiotic use by 30% without increasing infection recu…

This study tested whether a combination of 11 blood markers can more accurately diagnose late-onset sepsis in newborns in the NICU. Current methods are slow and often lead to unnecessary antibiotic use. Researchers enrolled 233 newborns with signs of infection to see if this biom…

This study looked at 58 full-term newborns with suspected early-onset sepsis to find early clinical signs that could help doctors tell if a bacterial infection is present. Researchers reviewed medical records from 2013 at a single hospital. The goal was to improve diagnosis and a…

This study looked at 102 patients with bloodstream infections to compare standard lab cultures with two new rapid detection methods. The goal was to see how long germs stay in the blood and whether the new tests can give faster, more accurate results. This information could help …

This study looked at whether giving antibiotics early to extremely low birthweight babies (born before 31 weeks) might cause more harm than good. Researchers compared babies who got standard antibiotics to those who got a placebo. The goal was to see if early antibiotics increase…

This completed study looked at whether a regional guideline for managing sepsis (a severe infection) in pregnant and postpartum women improved outcomes. Researchers compared 52 women treated before and after the guideline was introduced in Lombardy, Italy. They measured hospital …

This completed study looked at how common gut inflammation and leaky gut are in 80 adults with blood cancer who were in intensive care for sepsis or septic shock. Researchers measured two markers—calprotectin in stool and zonulin in blood—to better understand intestinal dysfuncti…