Gonorrhea

This first-in-human trial tests an experimental vaccine called LTB-NG6, designed to protect against gonorrhea. The study will enroll healthy adults aged 18-50 to evaluate the vaccine's safety and its ability to trigger an immune response. Participants will receive either the vacc…

This study compares two doses of the antibiotic ceftriaxone—500 mg versus 1000 mg—given as a single shot to treat uncomplicated gonorrhea. Researchers want to see if the lower dose works just as well, which could mean fewer side effects and less antibiotic use. The trial involves…

This study provides free testing for chlamydia, gonorrhea, syphilis, and HIV to Black youth aged 15-26 in New Orleans. Those who test positive can get treatment at no cost and are encouraged to bring their partners. The goal is to reduce STI rates and health disparities in this c…

This trial tests two strategies to control sexually transmitted infections (STIs) among 2,900 cisgender men who have sex with men in Kenya. One group gets a single dose of antibiotics every few months (WHO-recommended periodic presumptive treatment), another takes doxycycline wit…

This study is testing a new rapid test for gonorrhea called the iStatis Gonorrhea Antigen Test. The test uses a vaginal swab and gives results quickly at the clinic. Researchers want to see how accurate and easy it is to use when performed by trained staff. About 650 women will t…

This study is testing a new, quick test for gonorrhea in pregnant women and women with symptoms in South Africa. About 1,239 women will provide samples to see if the new test works as well as standard lab methods. The goal is to make diagnosis faster and easier, especially in cli…

This study is testing three new diagnostic tests to see if they can correctly identify a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will use leftover samples from over 3,000 people who already tested positive for gonorrhea. If the te…

This study will test whether screening pregnant women for chlamydia and gonorrhea can reduce the risk of preterm birth. About 2,000 women in Botswana will be randomly assigned to receive either standard care or additional STI testing early in pregnancy and again in the third trim…

This study in Botswana tests whether offering sexually transmitted infection (STI) testing alongside HIV prevention medication (PrEP) helps more pregnant women start and continue using PrEP. About 600 pregnant women without HIV will be split into two groups: one gets standard car…

This study tests whether taking the antibiotic doxycycline can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in adolescent and young adult females. About 760 participants aged 13-29 who have had an STI in the past year and recent…

This study tests an online program called all2GETHER that teaches relationship and communication skills to gay, bisexual, and queer men, as well as transgender and non-binary people who partner with cisgender men. The goal is to see if the program can lower HIV and STI rates. 5,0…

This study tests a program called Shamba Maisha that provides farming tools, training, and school gardens to families in Kenya. The goal is to reduce food insecurity and poverty, which are linked to higher STI and HIV risk in adolescent girls. Researchers will follow 900 girls an…

This study tests whether taking the antibiotic doxycycline shortly after sex can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 men, transgender women, and travestis in Rio de Janeiro who are at higher risk. Participants choose whether to use doxy…

This study tests whether taking a single 200 mg dose of doxycycline within 24–72 hours after unprotected sex can prevent gonorrhea, chlamydia, and syphilis in men who have sex with men. Researchers in Bangkok will enroll 400 participants and follow them for 12 weeks. If effective…

This study in Uganda tests whether adding lab tests for common sexually transmitted infections (STIs) to standard HIV risk screening helps more women start and stick with PrEP, a daily pill that prevents HIV. About 4,500 HIV-negative women aged 15-39 will be randomly assigned to …

This study tests whether offering rapid point-of-care testing for gonorrhea and chlamydia helps more teens get HIV testing and PrEP. About 6,460 adolescents aged 16-24 will be compared: some get rapid testing, others get standard lab testing. The goal is to see if same-day result…