Glucose metabolism disease

This study tests whether tirzepatide, a drug used for type 2 diabetes, can help people with type 1 diabetes. Researchers will measure how the body responds to insulin and meals before and after 6 weeks of treatment. 44 adults with type 1 diabetes who use an automated insulin pump…

This study tests whether a drug called AMX0035 can improve how the body responds to insulin in adults with type 1 diabetes. Participants take either AMX0035 or a placebo daily for 24 weeks. Researchers measure insulin sensitivity using a glucose clamp test and track blood sugar c…

This study tests a once-daily pill called orforglipron in adults with type 2 diabetes who plan to fast during Ramadan. The goal is to see if the drug helps control blood sugar and weight without causing harm. About 130 participants will take the pill for up to 48 weeks, with clin…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells enclosed in a protective capsule, for people with unstable type 1 diabetes who still experience severe low blood sugar episodes despite using an automated insulin pump and continuous glucose m…

This study tests whether an online training and peer support platform (Support-t) helps teens with type 1 diabetes prepare for the move from pediatric to adult healthcare. About 200 teens aged 14-16 will either use the platform plus usual care or just usual care. The main goal is…

This phase 2 trial tests whether taking taurine, a natural amino acid found in energy drinks and supplements, can improve blood sugar, cholesterol, and inflammation in people with type 2 diabetes. About 94 adults with diabetes will take either taurine powder or a placebo twice da…

This study tests whether a continuous glucose monitor (CGM) worn on the arm can diagnose gestational diabetes as well as the standard oral glucose tolerance test (OGTT). Pregnant women of Chinese or Indian ethnicity will wear the sensor for up to 10 days and also undergo the OGTT…

This study is testing whether a special PET/MRI scan using 18F-DOPA can accurately locate small, overactive areas in the pancreas that cause too much insulin (hyperinsulinism). The goal is to help doctors decide if surgery can remove just the problem spot, potentially curing the …

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This early-stage trial is testing how well different tablet versions of the experimental drug elecoglipron are absorbed by the body. Healthy volunteers receive a single dose of one formulation, and researchers measure drug levels in the blood over time. The goal is to compare the…

This observational study follows people with Glycogen Storage Disease Type Ia who have already received the gene therapy DTX401. The goal is to track their health and safety for at least 10 years after treatment. No new drugs or treatments are given in this study. It will help re…

This study compares how natural sugar (sucrose) and the artificial sweetener sucralose affect blood sugar control and metabolism in 120 adults with normal weight, overweight, or obesity. Participants will consume low or high doses of each sweetener in solid or liquid form over 12…

This study aims to develop a better way to measure how the brain uses sugar (glucose) for energy. Researchers will use advanced MRI-like scans at 3 or 7 Tesla strength in 20 healthy volunteers and people with Glut1 deficiency, a rare condition that affects brain fuel. Participant…

This study tracks blood sugar levels in 100 healthy soldiers as they complete a 6-kilometer march carrying 15 kilograms of gear. Researchers will use continuous glucose monitors and heart rate sensors to see how exercise affects glucose and the nervous system. The goal is to bett…

This study looks at how different sources of protein (animal vs. plant, and whole foods vs. protein powders) affect blood sugar control and insulin sensitivity in people with metabolic syndrome. Researchers will measure blood sugar levels over 24 hours and use a special test to s…

This study looks at how a drug called diazoxide, which activates certain brain centers, can change how much sugar the liver makes. People with type 2 diabetes often have livers that produce too much sugar, leading to high blood sugar. The study will involve 100 participants (both…

This study will use special 'tracer' molecules (stable isotopes) to measure how the body of an adult with obesity processes protein and sugar. Eight participants will each undergo two test sessions: one measuring protein breakdown and another measuring glucose tolerance. The goal…

This study looks at how a heart hormone called atrial natriuretic peptide (ANP) affects metabolism and heart health. Researchers will test 200 adults with different genetic versions of ANP to see how their bodies respond to exercise and sugar. The goal is to understand why some p…

This study looks at how different amounts of water and non-sugar drinks affect hydration, blood sugar, and heart health in 144 adults. Participants will follow specific drinking plans over several weeks. The goal is to see if simply drinking more fluids—with or without sweeteners…

This study looks at whether using chlorhexidine mouthwash before eating carbs changes blood sugar levels. Researchers think killing mouth bacteria might interfere with early carbohydrate digestion. About 45 healthy adults will rinse with either chlorhexidine or a placebo, then ea…