Disorder of appendix

This study tests an experimental vaccine (RO7198457) in people with stage II or III colorectal cancer who have signs of remaining cancer DNA in their blood after surgery. The goal is to see if the vaccine can prevent the cancer from returning better than simply watching and waiti…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infu…

This early-phase study tests a new drug called RMC-6291 in adults with advanced cancers (lung, colon, pancreatic) that have a specific KRAS G12C mutation. The goal is to find the safest dose and see how well the drug works. About 222 participants will receive the drug by mouth, a…

This study tests whether giving a probiotic called Lactobacillus plantarum after surgery for a burst appendix can reduce inflammation, pain, and hospital stay. Researchers will measure white blood cell counts and pain levels in 50 adults. The goal is to see if probiotics help con…

This study tests a new drug (JAB-21822) combined with cetuximab in people with advanced colorectal, small intestine, or appendiceal cancers that have a specific KRAS G12C mutation. Participants must have already tried at least one standard treatment. The goal is to see if the com…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This study compares two ways of giving chemotherapy directly into the belly after surgery to remove visible cancer from the lining of the abdomen. The cancer comes from the appendix, colon, or rectum. About 292 adults will be randomly assigned to receive either early post-operati…

This study looks at whether using an antibiotic solution to wash the surgical area during laparoscopic appendix removal can lower the chance of wound infections in children with a burst appendix. About 200 children aged 18 or younger will take part. The goal is to find a better w…

This study looks at whether a blood test can detect if cancer comes back after surgery for colorectal or appendix cancer that spread to the abdomen. Researchers will collect blood samples from 55 patients before and after surgery to measure DNA changes. The goal is to see if this…

This study looks at 70 children aged 7 to 12 having appendix surgery. It compares two ultrasound-guided pain blocks to see which one reduces the need for extra pain medicine and improves recovery. The goal is to find a safer, more effective way to manage pain after surgery.

This study looks at whether chemotherapy slows tumor growth in people with a rare type of appendiceal cancer that has spread. About 30 participants will be observed with and without chemotherapy to compare tumor growth rates. The goal is to give doctors clearer guidance on whethe…

This study is for people with gastrointestinal cancer that has spread to the lining of the abdomen. Researchers will collect tumor tissue and blood samples to create a custom blood test that looks for cancer DNA. The goal is to see if this test can help doctors monitor the cancer…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study looks at 400 adults with acute appendicitis to figure out who can be treated with antibiotics alone and who needs surgery. Researchers will track lab results, imaging, and symptoms to see which approach works best for each patient. The goal is to help doctors choose th…

This study looks back at 193 people with stomach, appendix, or colon cancer who had surgery with or without heated chemotherapy (HIPEC). Researchers want to see if HIPEC affects how quickly the bowels start working again after surgery and whether it leads to more complications. T…