New vaccine aims to stop colorectal cancer recurrence in High-Risk patients

NCT ID NCT04486378

Ongoing Disease control Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 4 times

Summary

This study tests an experimental vaccine (RO7198457) in people with stage II or III colorectal cancer who have signs of remaining cancer DNA in their blood after surgery. The goal is to see if the vaccine can prevent the cancer from returning better than simply watching and waiting. About 327 participants will be randomly assigned to receive the vaccine or no immediate treatment.

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Conditions

The condition(s) this trial relates to.

appendiceal neoplasm carcinoid tumor colon adenocarcinoma colorectal cancer colorectal carcinoma colorectal neoplasm goblet cell carcinoma neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER STAGE II COLORECTAL CANCER STAGE III

Contacts and locations

Locations

AZ Delta Roeselare

Roeselare, 8800, Belgium
AZ Groeninge

Kortrijk, 8500, Belgium
Allina Health

Minneapolis, Minnesota, 55407, United States
Asklepios Klinik Altona

Hamburg, 22763, Germany
Beatson West of Scotland Cancer Centre - Gartnavel Royal Hospital - NHS Greater Glasgow and Clyde

Glasgow, G12 0XH, United Kingdom
Centres Hospitaliers Jolimont

La Louvière, 7100, Belgium
Charité - Universitätsmedizin Berlin

Berlin, 10117, Germany
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust

Oxford, OX3 7LE, United Kingdom
Clinica Universitaria de Navarra

Pamplona, 31008, Spain
Complejo Hospitalario Universitario A Coruna

A Coruña, 15006, Spain
Complejo Hospitalario Universitario De Santiago De Compostela

Santiago de Compostela, 15706, Spain
Complejo Hospitalario de Navarra (CHN)

Pamplona, 31008, Spain
Complejo Hospitalario de Orense

Ourense, 32005, Spain
Complexo Hospitalario Universitario de Vigo (CHUVI)

Vigo, 36312, Spain
Consorcio Hospital General Valencia

Valencia, 46014, Spain
Dorset County Hospital NHS Foundation Trust - Dorset County Hospital

Dorchester, DT1 2JY, United Kingdom
GHDC (Grand Hopital de Charleroi)

Charleroi, 6000, Belgium
GasthuisZusters Antwerpen - Sint-Augustinus

Wilrijk, 2610, Belgium
Guy's and St Thomas' Hospital NHS Foundation Trust

London, SE1 7EH, United Kingdom
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain
Hospital Nuestra Senora de Sonsoles

Ávila, 05004, Spain
Hospital Regional Universitario Carlos Haya Malaga - Instituto de Investigacion Biomedica de Malaga

Málaga, 29011, Spain
Hospital Universitari Germans Trias - ICO Badalona

Badalona, 08916, Spain
Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain
Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain
Hospital Universitario HMN Sanchinarro, Centro Integral Oncologico Clara Campal (CIOCC)

Madrid, 28050, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Marques De Valdecilla

Santander, 39008, Spain
Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain
Hospital Universitario Puerta de Hierro de Majadahonda

Majadahonda, 28222, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario Reina Sofia

Córdoba, 14004, Spain
Hospital Universitario Virgen del Rocio - Hospital de la Mujer

Seville, 41013, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, 8041, Spain
Hull and East Yorkshire Hospitals NHS Trust - Castle Hill Hospital

Cottingham, HU16 5JQ, United Kingdom
Hämatologisch-Onkologische Praxis Eppendorf

Hamburg, 20249, Germany
Imeldaziekenhuis General Hospital

Bonheiden, 2820, Belgium
Indiana University Melvin and Bren Simon Comprehensive Cancer

Indianapolis, Indiana, 46202, United States
Institut Clinic Hematolo/Oncologia- ICMHO, Hospital Clinic i Provincial de Barcelona

Barcelona, 8036, Spain
Krankenhaus Nordwest GmbH - Institut Fuer Klinisch-Onkologische Forschung (IKF)

Frankfurt am Main, 60488, Germany
LMU Klinikum (Campus Großhadern) Medizinische Klinik Universität München

München, 81377, Germany
Lunds Universitet - Medicinska Fakulteten (Lund University Faculty of Medicine)

Lund, 221 00, Sweden
Marin Cancer Care

Greenbrae, California, 94904, United States
Medizinische Hochschule Hannover

Hanover, 30625, Germany
National Center for Tumor Diseases (NCT) Heidelberg

Heidelberg, 69120, Germany
Northwest Cancer Specialists P.C.

Vancouver, Washington, 98684, United States
OhO Ostholstein Onkologie

Oldenburg in Holstein, 23758, Germany
Oncology Hematology Care Clinical Trials

Cincinnati, Ohio, 45245, United States
Princess Margaret Cancer Centre

Toronto, M5G 1X6, Canada
Prosper Hospital

Recklinghausen, 45659, Germany
Queen Elizabeth Hospital Birmingham-University Hospitals Birmingham NHS Foundation Trust

Birmingham, B15 2GW, United Kingdom
Rhode Island Hospital

Providence, Rhode Island, 02906, United States
Rocky Mountain Cancer Centers - Denver Midtwon

Denver, Colorado, 80218, United States
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust

Preston, PR2 9HT, United Kingdom
SLK-Kliniken Heilbronn GmbH

Heilbronn, 74078, Germany
Sarah Cannon (Tennessee Oncology - Nashville)

Nashville, Tennessee, 37203, United States
Sodersjukhuset, Onkologiska Kliniken

Stockholm, 11883, Sweden
St Bartholomew's Hospital-Barts Health NHS Trust

London, EC1A 7BE, United Kingdom
Studiengesellschaft BSF

Halle, 06108, Germany
Texas Oncology - Northeast Texas

Tyler, Texas, 75702, United States
Texas Oncology, P.A. - Austin

Austin, Texas, 78705, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75246, United States
Texas Oncology-San Antonio Medical Center

San Antonio, Texas, 78240, United States
The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust

Bebington, CH63 4JY, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust - Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
The Ottawa Hospital Cancer Centre

Ottawa, K1H 8M2, Canada
The Royal Marsden NHS Foundation Trust

Sutton, SM25NG, United Kingdom
The Royal Marsden NHS Foundation Trust- Chelsea

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Torbay Hospital - South Devon Healthcare Nhs Foundation Trust, Lowes Bridge

Torquay, TQ2 7AA, United Kingdom
Universitaetsklinikum Leipzig AoeR

Leipzig, 04103, Germany
Universitaetsklinikum St. Josef-Hospital Bochum

Bochum, 44791, Germany
Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz KoeR

Mainz, 55131, Germany
Universitaire Ziekenhuizen Leuven

Leuven, 3000, Belgium
University College London Hospitals NHS Foundation Trust

London, NW2 1PG, United Kingdom
University of Washington

Seattle, Washington, 98109, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53792, United States
Universitätsklinikum Bonn, Med. Klinik u. Poliklinik I

Bonn, 53105, Germany
Universitätsklinikum Hamburg-Eppendorf

Hamburg, 20246, Germany
Universitätsklinikum Ulm

Ulm, 89081, Germany
Universitätsklinikum Würzburg

Würzburg, 97080, Germany
VZW Algemeen Ziekenhuis AZ Klina

Brasschaat, 2930, Belgium
Velindre NHS Trust, Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States

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