Dengue disease

This study tests a dengue vaccine in adults aged 60 to 79 and compares their immune response and safety to adults aged 40 to 59. About 997 healthy participants will receive one dose of the Butantan dengue vaccine. The goal is to see if the vaccine works as well in older adults as…

This study tests a new dengue vaccine called V181 in 12,000 healthy children aged 2 to 17. The goal is to see if the vaccine is safe, triggers a strong immune response, and reduces cases of dengue fever caused by any of the four dengue virus types. Participants will receive eithe…

This study tests a dengue vaccine (TDV) in children aged 6 to 21 months. The goal is to see if the vaccine is safe and triggers a strong immune response. Participants receive two shots three months apart and are monitored for side effects and antibody levels.

This phase 3 trial is testing a dengue vaccine (TDV) in 800 adults aged 45 to 79, including those with diabetes, high blood pressure, or kidney disease. Participants will receive two shots three months apart. The study aims to check for side effects and measure the immune respons…

This pilot trial tests whether intravenous zanamivir, a drug already used for flu, can reduce vascular permeability — the dangerous blood vessel leakage that is the main cause of death in dengue fever. About 74 people with dengue and warning signs will receive either zanamivir or…

This Phase 2 trial tests an experimental drug called EYU688 in 108 adults with dengue fever. Participants receive either the drug or a placebo to see if it lowers the amount of virus in the blood and shortens fever. The study is currently recruiting.

This study tests a new medicine called CP-COV03 in adults with dengue fever. The goal is to see if it can safely lower the amount of virus in the blood and help people feel better faster. About 210 participants will receive either the drug or a placebo. The trial is currently rec…

This study is testing whether the steroid dexamethasone can help people with severe dengue. The researchers will give either dexamethasone or a placebo to 200 infected adults in Thailand. They want to see if the drug lowers the death rate and shortens hospital stays.

This study tests whether a special placental graft, used alongside standard wound care, helps close diabetic foot ulcers that won't heal on their own. About 350 adults with type 1 or 2 diabetes and a foot ulcer between 1 and 15 cm² will be randomly assigned to get the graft plus …

This phase 2 trial is testing two antivirals—molnupiravir (used for COVID-19) and a lab-made antibody called VIS513—in 500 people with early dengue. Participants must have had fever for less than 48 hours and a positive rapid test. The goal is to see if these drugs can clear the …

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether a special graft made from donated placental tissue, called XWRAP, can help heal diabetic foot ulcers that won't close with standard care alone. About 60 adults with type 1 or type 2 diabetes will receive either the graft plus standard wound care or standa…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study aims to understand how the human body responds to dengue virus infection, including in people who have had dengue before. Healthy volunteers aged 18 to 50 receive a single injection of a weakened dengue virus and are closely monitored for six months. Researchers measur…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This observational study will enroll 190 hospitalized adults with dengue in Bangladesh to see if a 'leaky gut' — where bacteria and toxins escape the intestines into the blood — is linked to severe disease. Researchers will measure gut leakage markers in blood, perform abdominal …

This study measures how common heart disease, diabetes, obesity, and infections like dengue and COVID-19 are among adults in La Reunion. Researchers will also look at possible risk factors, including gut bacteria, genetics, and social conditions. Participants provide blood, DNA, …

This study looks at whether the dengue vaccine (TDV) helps prevent hospital stays due to dengue in children and teens in Thailand, Indonesia, and Malaysia. Researchers will follow 70,000 participants for 3 years, comparing those who got the vaccine with those who did not. The goa…

This study creates a registry to collect data on dengue infections in people with congenital bleeding disorders like hemophilia. Dengue can cause serious bleeding, and those with bleeding disorders may face higher risks. The goal is to understand bleeding complications, treatment…

This study involves giving a weakened dengue virus to 5 healthy adults aged 21-45 in Singapore to safely study how the body fights the infection. The goal is to create a reliable model for testing future dengue vaccines and treatments. Participants will be closely monitored for s…

This study tracks 500 pregnant women in the US who received the Dengvaxia dengue vaccine. Researchers will monitor mothers and their babies for any side effects or pregnancy complications. The goal is to gather safety data, not to test the vaccine's effectiveness.

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study follows 100 people with confirmed dengue to identify which symptoms and lab results predict hospitalization. It also tracks how often blood transfusions are given and their outcomes. The goal is to improve care for dengue patients, not to test a new treatment.