Dengue vaccine trial aims to protect seniors

NCT ID NCT06891950

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Butantan Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 5 times

Summary

This study tests a dengue vaccine in adults aged 60 to 79 and compares their immune response and safety to adults aged 40 to 59. About 997 healthy participants will receive one dose of the Butantan dengue vaccine. The goal is to see if the vaccine works as well in older adults as it does in younger adults.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Butantan dengue vaccine (live attenuated virus for serotypes 1-4)
What this could lead to: If successful, this could show the vaccine is safe and effective for older adults, expanding protection against dengue to a vulnerable age group.
What could go wrong: This is a non-inferiority trial comparing age groups, not a final efficacy study. The vaccine may not work as well in older adults, and side effects could differ.

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Conditions

The condition(s) this trial relates to.

dengue disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DENGUE

Contacts and locations

Locations

CWB 02 - Centro Médico São Francisco
RECRUITING

Curitiba, Paraná, 80810-050, Brazil
PET 01 - Hospital Escola da Universidade de Pelotas - HEUFPEL
RECRUITING

Pelotas, Rio Grande do Sul, 96040-010, Brazil
POA 01 - Centro de Pesquisa: Hospital São Lucas - PUCRS
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
POA 02 - Associação Hospitalar Moinhos de Vento
RECRUITING

Porto Alegre, Rio Grande do Sul, 90560-032, Brazil
POA 05 - Núcleo de Pesquisa do Rio Grande do Sul
RECRUITING

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

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