Cytomegalovirus pneumonia

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This large Phase 3 trial is testing an experimental drug called tozorakimab in about 2,870 adults hospitalized with a viral lung infection who need extra oxygen. Participants receive either a single dose of tozorakimab or a placebo, added to standard care. The main goal is to see…

This study tests whether a daily pill called AP1189 can help hospitalized patients with breathing failure due to viruses like flu, RSV, or COVID-19. About 96 adults will receive either AP1189 or a placebo for 14 days, on top of usual care. The main goal is to see if the drug redu…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This trial investigates whether a rapid C-reactive protein (CRP) blood test can help doctors decide when antibiotics are truly needed for adults with acute respiratory infections in Indonesian primary health clinics. Many such infections are viral and do not require antibiotics, …

This study tests whether ColdZyme mouth spray can lower the amount of virus people breathe out when they have a cold or flu. Researchers will measure virus particles in exhaled air before and after using the spray. The goal is to see if the spray might help reduce airborne transm…

This study tests whether giving oral antibiotics instead of IV antibiotics is just as safe and effective for patients with common infections like pneumonia, urinary tract infections, and cellulitis. About 4,000 adults in Danish emergency rooms will be randomly assigned to start o…

This study tests a new technology called Pictura Bio that aims to detect respiratory viruses quickly and cheaply from nose or throat swabs. Researchers will collect samples from 1000 adults and children with suspected viral infections at a UK hospital. The data will be used to tr…

This study is testing a finger-prick blood test called FebriDx in 800 children aged 2-11 who have a fever and symptoms of a respiratory infection. The goal is to see if the test can quickly tell whether the infection is caused by bacteria or something else (like a virus). If accu…

This study is testing whether measuring a natural immune marker called IFN-I in nasal swabs can help detect respiratory viral infections in older adults. Current PCR tests only look for a few viruses and can miss others or show old infections. The goal is to improve diagnosis, es…

This study is testing a new diagnostic tool that helps doctors quickly tell if a respiratory infection is caused by bacteria or a virus. The goal is to see if using this test leads to better treatment decisions, fewer unnecessary antibiotics, and lower healthcare costs. About 100…

This study tests whether adding a special breathing treatment called intrapulmonary percussive ventilation (IPV) to standard care helps patients with pneumonia who are on a breathing machine. About 96 adults will be randomly assigned to receive either standard therapy alone or st…

This study tests whether a higher-dose version of the drug Ingavirin can help adults with the flu or other viral infections feel better faster. About 300 people will receive either the study drug or a placebo. The main goal is to see how quickly symptoms like fever, cough, and so…

This study tests whether a liquid medicine called Rengalin can safely reduce coughing in children aged 6 months to 3 years who have a viral cold or flu. About 264 children will take either Rengalin or a placebo three times a day for 7 days. The main goal is to see if more childre…

This study gathers fluid and tissue from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare samples to find differences in immune function that might explain why some people are more prone to infections. Participants un…

This study will follow 2,000 people of all ages who visit their doctor with symptoms of an acute respiratory infection, like cough, sore throat, or runny nose. Researchers will collect information on symptoms, treatments, and lab results to better understand how these infections …

This study aims to collect blood, nose, and saliva samples from up to 20,000 people aged 3 and older who have or may have a respiratory virus infection like flu or COVID-19. The samples will be stored and used in future research to better understand these viruses and how the immu…

This study aims to identify the types of fungi causing pneumonia in immunocompromised ICU patients and test how resistant they are to antifungal drugs. Researchers will collect samples from 250 adults in intensive care who have pneumonia that does not respond to antibiotics. The …

This study tracks respiratory infections in thousands of patients across China to build a better early warning system. Researchers collect routine medical data and samples to identify which germs are circulating and how the body responds. The goal is to help hospitals and health …

This study tests whether implementing new Swiss national guidelines for acute respiratory infections can reduce unnecessary antibiotic prescribing in primary care. Researchers will work with 200 family doctors in quality circles and walk-in clinics, providing training and materia…

This study is observing 2,000 children under 2 years old in Ho Chi Minh City who have respiratory infections. Researchers will test for RSV, track how the virus spreads across seasons, and measure the illness's impact on families, including medical costs. No new treatments or vac…

This study looks at whether having a respiratory infection in the past changes how your lungs react to ozone, a common air pollutant. One hundred healthy adults will breathe ozone while exercising and have their lung cells sampled. The goal is to understand why some people may be…

This study tests two ways to help general practitioners (GPs) use antimicrobial stewardship resources when treating respiratory tract infections. One group gets online training and self-audit tools; the other gets face-to-face support. Researchers will track how often GPs use the…

This study looks at the types of germs and their resistance genes in 800 people with pneumonia. Researchers will compare severe and mild cases to understand which microbes and resistance patterns are most common. The goal is to improve how doctors diagnose and treat pneumonia, es…

This study looks at whether a quick lab test (Spotfire R/ST) can help doctors decide when antibiotics are truly needed for people with respiratory infections like colds or sore throats. About 800 urgent care patients will take part, and researchers will compare antibiotic use bef…

This study looks at whether a special breathing therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a lung imaging tool (EIT) to see how well the therapy works. About 62 adults in the ICU will take p…

This study will follow 1,000 adults who come to fever clinics with a respiratory infection. Researchers will collect data on symptoms, lab tests, and chest scans at the start, then check in over time to see who develops pneumonia or other complications. The goal is to better unde…

This study in Kyrgyzstan is testing whether using a rapid C-reactive protein (CRP) blood test and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections like coughs and sore throats. About 1050 adults will be randomly assign…