Conversion disorder

This early-stage trial is testing whether a single oral dose of ayahuasca can reduce the frequency of psychogenic non-epileptic seizures (PNES) in adults aged 18 to 60. Participants must have PNES confirmed by video-EEG and will taper off psychiatric medications before the dose. …

This study tests whether a type of talking therapy called neurobehavioral therapy (NBT) can help people with motor functional neurological disorder (mFND), a condition where the brain has trouble sending the right signals to the body, causing movement problems. The trial will com…

This study tests a new type of talk therapy called ReACT for adults with functional seizures (also called psychogenic non-epileptic seizures). The therapy aims to help people regain control over their body by changing thoughts and behaviors that trigger seizures. Fifty participan…

This study tests whether a non-invasive brain stimulation technique called theta-burst rTMS can help people with motor functional neurological disorder (FND), a condition causing movement problems without a clear brain lesion. Twenty-two adults with FND will receive 40 sessions o…

This study tests a new cognitive behavioral therapy called ReACT for teens aged 11-18 with psychogenic non-epileptic seizures (PNES) – episodes that look like seizures but are not caused by epilepsy. The therapy focuses on helping teens regain a sense of control over their body a…

This study tests a behavioral therapy called ReACT for teens aged 11-18 with functional seizures (non-epileptic). The therapy involves 12 sessions with a therapist to help manage seizures. Researchers want to see if a larger study is possible by checking how many teens join, stic…

This study tests whether a 24-week collaborative care program can improve quality of life for adults with epilepsy who also have anxiety or depression. The program includes regular check-in calls and expert recommendations from a psychiatrist and neurologist. Researchers will com…

This study tests whether a single clinic visit with a special attention exercise can help people with Functional Cognitive Disorder (FCD), a condition causing memory and thinking problems without a clear physical cause. About 30 adults aged 65 or younger will try the intervention…

This early study tests whether an accelerated form of transcranial magnetic stimulation (TMS) is feasible and tolerable for people with functional seizures (also called psychogenic non-epileptic seizures). Thirty adults will receive up to 30 TMS sessions over 3–5 days, targeting …

This study tests a new cognitive behavioral therapy called ReACT for children aged 9-18 with psychogenic non-epileptic seizures (PNES) — episodes that look like seizures but have no physical cause. The therapy focuses on helping kids feel more in control and less afraid of their …

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study will create and test a team-based treatment program for people with Functional Neurological Disorder (FND), a condition that causes symptoms like seizures, dizziness, and tics without a clear physical cause. Researchers will enroll 1,100 adults and children at the Univ…

This study is testing whether a small monitor worn on the thigh can reliably measure daily activity in people with Functional Neurologic Disorder (FND). The goal is to see if this remote tool gives a better picture of how symptoms affect real-world function than a single clinic v…

This study tests whether a structured, empathetic explanation of a functional neurological movement disorder diagnosis helps patients understand their illness better and feel more satisfied. About 35 adults with conditions like functional tremor or seizures will receive the speci…

This study looks at how often dissociative identity disorder (DID) occurs in adults who experienced childhood trauma and have borderline personality disorder, functional dissociative crises, or early psychosis. Researchers will use interviews and questionnaires with 350 participa…

This study reviews medical records of 1,000 patients who came to the hospital with sudden neurological symptoms like weakness, speech problems, or seizures. The goal is to find out how many are diagnosed with Functional Neurological Disorder (FND), a condition where the brain doe…

This study follows 1,000 adults in Lombardy, Italy, who have early memory complaints but no dementia. Researchers will use blood tests and annual check-ups over 5 years to see if certain biomarkers can predict who later develops Alzheimer's. The goal is to improve early detection…

This study aims to create and test a telehealth program to help veterans with psychogenic nonepileptic seizures (PNES) improve their thinking skills and daily functioning. About 47 veterans with PNES who report cognitive difficulties will give feedback to design a cognitive treat…

This pilot study is testing whether virtual reality motor tasks can help understand functional tremor, a type of movement disorder. Researchers will measure reaction time and brain activity in 48 people with functional tremor, essential tremor, or healthy controls. The goal is to…

This observational study at the Medical University of Graz will examine 216 people with movement disorders like Parkinson's, tremor, or dystonia to see how many also have functional neurological symptoms. Participants will undergo neurological exams, cognitive tests, and question…