Complex regional pain syndrome type 2
MONDO:0020572Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia, not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.
Also known as: CRPS II, Complex regional pain syndrome II, causalgia
129 clinical trials for this condition and its sub-types.
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Can super glue stop pain device leads from slipping?
Disease control CompletedThis study tested whether adding Dermabond (a medical glue) to stitches helps keep spinal cord stimulator leads from moving after placement. 57 adults with chronic pain had their leads secured either with stitches alone or with stitches plus glue. The main goal was to measure how…
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New tool aims to reduce opioid risks for older adults
Disease control CompletedThis study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Can coaching help veterans use cannabis for pain?
Symptom relief CompletedThis study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Participants will learn strategies to manage pain and related symptoms. The goal is to see if this coaching improves pain relief and satisfaction.
Phase: NA • Sponsor: University of Michigan • Aim: Symptom relief
Last updated Jul 01, 2026 00:00 UTC
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One-Size-Fits-All pain treatment fails half of patients – new study tests personalized approach
Symptom relief CompletedThis study tested whether tailoring magnetic brain stimulation to each person's brain signals can better relieve chronic pain. Researchers measured brain activity before treatment to customize the stimulation. 90 adults with chronic pain took part. The goal was to see if this per…
Phase: NA • Sponsor: Aalborg University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Talking teens out of pain: can motivation and Self-Management help?
Symptom relief CompletedThis study tested whether a short motivational interview combined with self-management techniques could help Hungarian teens aged 12-18 who have had chronic pain for at least 3 months. The program included a 30-minute in-person session plus two follow-up phone calls. Researchers …
Phase: NA • Sponsor: Semmelweis University • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Mind over pain: study tests if noticing pain fluctuations eases suffering
Symptom relief CompletedThis study from Harvard University tested whether mindfully noticing changes in pain throughout the day can help people with chronic pain feel more in control and reduce pain intensity. 300 adults with chronic pain for at least six months were split into groups that either paid c…
Phase: NA • Sponsor: Harvard University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New app aims to help young people take control of chronic pain
Symptom relief CompletedThis study tested a smartphone app and website called iCanCope with Pain, designed to help teens and young adults (ages 15-25) manage chronic pain. The app lets users track pain, sleep, mood, and activity, set goals, and learn coping strategies. The goal was to see if the program…
Phase: NA • Sponsor: The Hospital for Sick Children • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Heat waves for pain? RF ablation study shows promise
Symptom relief CompletedThis completed study looked at how well radiofrequency ablation (a procedure that uses heat to calm pain nerves) works for people with chronic pain. 298 participants were treated with a Boston Scientific device and then rated their improvement. The goal was to see real-world resu…
Sponsor: Boston Scientific Corporation • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Virtual pain relief: which app works best?
Symptom relief CompletedThis study tested two at-home digital programs for chronic pain: a virtual reality (VR) program and a self-guided online course. 330 adults with chronic pain used one of the programs for 8 weeks. Researchers measured changes in pain intensity and how pain affected daily life. The…
Phase: NA • Sponsor: Cedars-Sinai Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:01 UTC
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New program aims to ease chronic pain in korean american communities
Symptom relief CompletedThis study tested a 10-week education program designed to help Korean Americans with chronic pain. The program taught coping strategies and pain management skills in group sessions held at community centers. Researchers wanted to see if the program was feasible and acceptable, an…
Phase: NA • Sponsor: George Washington University • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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3-Session program shows promise for chronic pain and trauma
Symptom relief CompletedThis study tested a brief, three-session program for people with chronic pain and a history of stressful or traumatic experiences. The goal was to see if the program was practical and helpful. Fifty adults participated, and the study focused on whether people would join, complete…
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Virtual yoga shows promise for chronic pain relief
Symptom relief CompletedThis study tested whether a virtual yoga program could help people with chronic pain. 94 participants with pain lasting over 6 months took part in 8 weeks of remote yoga classes and daily 30-minute video-guided practice. Researchers measured how feasible the program was and wheth…
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Can online or Coach-Led sessions ease chronic pain? study finds out.
Symptom relief CompletedThis study tested two types of telehealth programs for people with chronic pain: an online self-guided program and live sessions led by a health coach via phone or video. Over 2,300 adults from four healthcare systems took part. The goal was to see if these programs could help re…
Phase: NA • Sponsor: Kaiser Permanente • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Could cannabis oil ease chronic pain? small trial aims to find out
Symptom relief CompletedThis pilot study tested an oral cannabinoid oil (CBD with a small amount of THC) in 51 adults with chronic pain. The goal was to see if it's practical to run a larger trial and to gather early data on pain relief and safety. Participants took the oil daily for up to 12 weeks, and…
Phase: NA • Sponsor: University Health Network, Toronto • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Hypnosis app shows promise for chronic pain sufferers
Symptom relief CompletedThis study tested a web app called Rose that provides hypnosis audio recordings for people with chronic pain. 100 adults with chronic low back pain or other chronic pain used the app for 8 weeks. The researchers measured how often people used it, their satisfaction, and changes i…
Phase: NA • Sponsor: University of Washington • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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New program helps chronic pain patients cut back on opioids
Symptom relief CompletedThis study looked at a voluntary program to help people with chronic pain slowly lower their opioid medications. 51 adults who wanted to reduce their opioid dose worked with their doctor over 4 months using a personalized tapering plan and a self-help book. The main goal was to s…
Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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New toolkit aims to ease chronic pain at work – but is it feasible?
Symptom relief CompletedThis study tested whether a toolkit called Pain at Work (PAW) can help employees with chronic pain manage their symptoms and stay productive. Around 380 workers from different workplaces in England took part, with some using the toolkit plus support calls and others receiving usu…
Phase: NA • Sponsor: University of Nottingham • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Can a faint zap beat pain? new study puts nerve stimulation to the test
Symptom relief CompletedThis study looked at whether very low-level electrical stimulation of nerves near the spine can reduce chronic pain more than a sham (inactive) device. Twenty adults who already have a nerve stimulator implant took part. Each person received both the real low-level stimulation an…
Phase: NA • Sponsor: Umeå University • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Can meditation help teens in pain? french study says yes!
Symptom relief CompletedThis study tested whether a mindfulness-based group therapy program, originally developed in Canada, could work for French teenagers aged 12-17 with chronic pain. The main goal was to see if teens would attend at least 6 out of 8 sessions. Researchers also looked at effects on pa…
Phase: NA • Sponsor: University Hospital, Toulouse • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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Which pill works better for chronic pain? study pits two drugs Head-to-Head
Symptom relief CompletedThis study compared two antidepressant medications, duloxetine and desipramine, to see which one reduces pain better in people with chronic pain. About 86 adults with pain lasting more than 3 months took one of the two drugs for six months. The main goal was to see how many peopl…
Phase: PHASE4 • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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Mind over pain: new program shows promise for chronic sufferers
Symptom relief CompletedThis study tested a mind-body program called GetActive for adults with chronic pain. The program combines relaxation techniques, coping skills, and physical activity (with or without a Fitbit). 82 participants completed the program, and researchers measured satisfaction, safety, …
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Could yoga and massage replace opioids for chronic pain?
Symptom relief CompletedThis study looked at whether offering telehealth sessions of massage, yoga, chiropractic, or physical therapy could help adults with chronic pain reduce their opioid use and feel better. Twenty-one people participated, and researchers tracked changes in pain intensity, pain inter…
Phase: NA • Sponsor: Washington State University • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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One class to ease teen pain? stanford tests Quick-Fix pain management
Symptom relief CompletedThis study tested a 90-minute pain management class for 110 youth aged 10-18 with chronic pain. The class teaches pain science and self-regulation skills like relaxation and cognitive techniques. Researchers checked if the class was acceptable and helpful by surveying participant…
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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New needling technique could ease chronic pain without drugs
Symptom relief CompletedThis pilot study tested a non-drug treatment called myoActivation for chronic pain in 41 marginalized people. The therapy uses a structured assessment and needling to release muscle tension. Researchers measured pain, function, and quality of life over 24 weeks to see if it helps…
Sponsor: University of British Columbia • Aim: Symptom relief
Last updated Jun 26, 2026 18:22 UTC
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Simple prompts may boost activity in chronic pain patients
Symptom relief CompletedThis study tested whether giving adults with chronic pain a user guide and weekly prompts helps them use an online pain-management resource more effectively. 99 participants were split into two groups: one got the guide and prompts, the other just the online resource. Researchers…
Phase: NA • Sponsor: Washington State University • Aim: Symptom relief
Last updated Jun 26, 2026 17:50 UTC
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New hope for failed back surgery? electrical pulses vs steroid shots
Symptom relief CompletedThis study tested two treatments for people with ongoing back pain after spinal surgery: pulsed radiofrequency (a procedure using mild electrical pulses) and a standard steroid injection. About 130 patients were followed for several months to see which approach reduced pain and i…
Phase: NA • Sponsor: Puerta de Hierro University Hospital • Aim: Symptom relief
Last updated Jun 26, 2026 14:19 UTC
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Can therapy cut opioid use in chronic pain? new study explores how.
Knowledge-focused CompletedThis study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid mis…
Phase: NA • Sponsor: University of Washington • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New tool aims to give chronic pain patients a stronger voice in the doctor's office
Knowledge-focused CompletedThis study talked to 50 adults with long-term (non-cancer) pain and their healthcare providers to learn about their experiences managing pain in primary care. The goal was to use this information to create a decision aid tool that helps patients and doctors make informed choices …
Sponsor: University of Aberdeen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:38 UTC
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Chronic pain patients share Real-Life device results in new study
Knowledge-focused CompletedThis study gathered information from 73 adults with chronic pain who were already using or planning to use an approved medical device (like a spinal cord stimulator) for their pain. Researchers asked participants to report their pain levels on a 0-10 scale and other outcomes duri…
Sponsor: Boston Scientific Corporation • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Study reveals hidden links between frailty and chronic pain in seniors
Knowledge-focused CompletedThis completed study looked at 393 adults aged 65 and older with chronic pain to see how frailty relates to the type and location of pain, as well as nutritional risk. Researchers measured frailty using standard criteria and assessed pain intensity and type. The goal is to help d…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Touchdown or pain down? study links football fandom to chronic pain fluctuations
Knowledge-focused CompletedThis study looked at whether the weekly performance of a favorite NFL team affects chronic pain in avid football fans. Thirty-two adults with chronic pain completed weekly surveys during the football season, rating their pain, mood, and pain-related thoughts. The goal was to see …
Sponsor: Evidence In Motion • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Spinal zaps studied to Fine-Tune pain relief
Knowledge-focused CompletedThis study looked at how spinal cord stimulation (SCS) affects pain processing in 34 people with chronic pain. Participants already had an SCS device as part of their care. Researchers tested different stimulation patterns (burst, kHz, tonic, and sham) to see how they changed the…
Phase: NA • Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Jaw and pelvic pain: a surprising link?
Knowledge-focused CompletedThis completed study from the University of Valencia looked at 133 adults with chronic pain to see if jaw (temporomandibular) pain is linked to pelvic pain. Participants filled out questionnaires about their pain, emotions, and sensitivity. The goal was to understand why these pa…
Sponsor: University of Valencia • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Chilean pain study reveals hidden toll on mental health
Knowledge-focused CompletedThis study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…
Sponsor: Pontificia Universidad Catolica de Chile • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC