Cholelithiasis

This study looks at whether older adults (80+ or 75+ with health issues) benefit more from gallbladder removal surgery or simply monitoring after their bile duct stones are cleared. About 400 participants will be followed for a year to compare deaths, major complications, and ret…

This study tests a capsule called CnU (750 mg) to see if it can dissolve cholesterol gallstones. About 484 adults with small, non-calcified gallstones will take the capsule for 24 weeks. The goal is to check if the stones shrink or disappear, and to ensure the treatment is safe.

This study compares three approaches for people with both gallstones and bile duct stones: a gallbladder-preserving procedure using an endoscope, ERCP plus gallbladder removal surgery, or conservative management with medication or watchful waiting. Researchers will track complica…

This study tests whether placing a small plastic tube (stent) in the pancreas during a gallstone removal procedure can prevent pancreatitis, a painful inflammation. 88 adults with both gallbladder and common bile duct stones will be randomly assigned to receive either standard ca…

This trial compares two doses of a dye called indocyanine green (ICG) given before laparoscopic gallbladder removal. The dye helps surgeons see the bile ducts clearly, which may reduce the risk of accidental injury. One group gets the standard dose hours before surgery; the other…

This study is testing whether a specific diet can help people pass very small gallstones (sludge) without surgery. One hundred adults with tiny stones (less than 2 mm) will be randomly assigned to a special diet or a control diet. The main goal is to see if the diet can completel…

This trial looks at whether removing the gallbladder early (during the same hospital stay) or waiting 4 weeks after recovery is better for people with severe pancreatitis caused by gallstones. About 134 adults will be randomly assigned to one of the two timing options. The main g…

This study compares standard ultrasound (done on the outside of the belly) with laparoscopic ultrasound (done inside the abdomen during weight-loss surgery) to see which finds more gallstones and other gallbladder issues. The goal is to better identify patients who could benefit …

Researchers compare two ways to remove the gallbladder during laparoscopic surgery: using an improvised retrieval bag or pulling it out directly. The trial enrolls 120 adults scheduled for elective gallbladder removal. They measure surgical time, gallbladder perforation, bile and…

This study compares two types of gallbladder removal surgery for non-cancerous conditions like gallstones or polyps. About 276 adults will be randomly assigned to either robotic or standard laparoscopic surgery. The main goal is to see if robotic surgery is as safe as the traditi…

This trial compares three common anesthetics—propofol, ciprofol, and remimazolam—to see which one leads to the least nausea and vomiting after gallbladder removal surgery. About 114 adults having laparoscopic cholecystectomy will be randomly assigned to one of the three drugs. Th…

This trial compares two drugs used to put people to sleep for gallbladder surgery: remimazolam and propofol. Researchers measure how quickly each drug causes loss of consciousness and check for side effects like low blood pressure. Participants are healthy adults aged 18–50 under…

This study will test whether giving dexamethasone, dexmedetomidine, or both right after gallbladder surgery helps the gut start working again sooner. 160 adults having laparoscopic gallbladder removal will be randomly assigned to one of four groups, including a placebo. The main …

This study compares two methods of removing the gallbladder during laparoscopic (keyhole) surgery: through a port near the belly button or one below the breastbone. The goal is to see which approach causes less pain and fewer wound problems like infection. The trial will involve …

This study compares two ultrasound-guided nerve blocks to control pain after laparoscopic gallbladder removal. Seventy adults will receive either a modified thoracoabdominal nerve block or a recto-intercostal fascial plane block. The goal is to see which block reduces the need fo…

This study tests whether a single dose of magnesium sulfate given during gallbladder surgery can lower the amount of morphine patients need afterward. 106 adults having laparoscopic gallbladder removal will be randomly assigned to receive either magnesium or a placebo. The goal i…

This study tests whether having patients keep a pain diary after gallbladder surgery helps them report their pain more accurately than standard methods. About 142 adults having laparoscopic gallbladder removal will either use a diary or receive usual care. The goal is to improve …

This study tests whether a non-invasive device called TENS, which delivers mild electrical currents through the skin, can reduce anxiety and pain and improve satisfaction in 80 adults having laparoscopic gallbladder removal. Participants will receive either standard care or TENS …

This study tests whether labetalol or lignocaine (lidocaine) is better at preventing sudden rises in heart rate and blood pressure when a breathing tube is inserted for gallbladder surgery. 116 adults having elective laparoscopic gallbladder removal will receive one of the two dr…

This study compares two ways to manage pain after laparoscopic gallbladder removal. One group gets standard local anesthesia at the incision sites, while the other also receives a nerve block guided by the surgery camera. The goal is to see if the added block reduces pain and the…

This study compares two types of breathing tubes used during gallbladder surgery: the standard endotracheal tube and a laryngeal mask airway. Researchers want to see if one requires less propofol (anesthesia medicine) to keep patients asleep. 160 adults having elective gallbladde…

This study looks at how gut bacteria and body chemistry change in people who have surgery to remove gallstones. Researchers will collect stool, urine, blood, and saliva samples before and after surgery from 65 adults. The goal is to understand these changes, not to test a new tre…

This study is testing whether a camera can accurately measure heart rate, blood pressure, and oxygen levels by recording a patient's face during surgery. The goal is to replace some of the sticky sensors and cuffs that touch the skin, which can cause infections or injuries in fra…

This study looks back at the records of 2,000 adults who had liver surgery with their gallbladder left in place. Researchers want to know if a technique called the Pringle maneuver, which temporarily stops blood flow to the liver during surgery, increases the chance of developing…

This study is collecting health data and biological samples from 15,000 people in Europe and Latin America to find markers that could predict gallbladder cancer risk or catch it early. Participants include patients with gallbladder cancer or gallstones. The goal is to improve pre…

This study compares a new orally disintegrating form of Trimedat (trimebutine) to the standard tablet in 36 healthy adults. The goal is to see if the new version is absorbed similarly and is safe. This trial does not treat any disease; it only gathers data on how the drug behaves…

This study follows 800 people with gallstones and belly pain who are scheduled for gallbladder removal surgery. Researchers will track their symptoms and quality of life before and three months after surgery. The goal is to create a simple tool that predicts who will actually get…