Cholangitis

This phase 2 trial is testing whether an experimental drug called HTD1801 can improve liver health in adolescents with primary sclerosing cholangitis (PSC), a rare disease that damages the bile ducts. Participants will receive either HTD1801 or the standard treatment, ursodeoxych…

This study tests a drug called elafibranor in 68 adults with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. The main goal is to check the drug's safety and side effects compared to a placebo. Researchers will also look at blood tests to see if…

This Phase 2 trial tests an experimental drug called CS0159 in 50 people with primary sclerosing cholangitis (PSC), a rare liver disease. The study has a 12-week placebo-controlled phase followed by a 40-week open-label period to check safety and how well the drug works. Research…

This study looks at whether a gluten-free diet can help people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). Researchers will track changes in symptoms, gut bacteria, and lab results in 60 adults over time. The goal is to see if avoiding gluten c…

This Phase 3 trial tests whether taking 40 mg of simvastatin daily for 5 years can improve outcomes for people with primary sclerosing cholangitis (PSC), a rare liver disease. About 560 patients will receive either simvastatin or a placebo. Researchers will track survival, need f…

This study looks at whether measuring certain substances in bile and blood can more accurately diagnose cancer in people with bile duct blockages. Researchers will compare these new tests with standard methods in 500 adults undergoing a procedure called ERCP. The goal is to find …

This study tests a medicine called volixibat to see if it can reduce severe itching in people with primary sclerosing cholangitis (PSC), a rare liver disease. About 182 participants will receive either volixibat or a placebo, and researchers will track itch scores using a daily d…

This trial is testing an investigational imaging device that uses shortwave infrared light to help surgeons see important structures like nerves, ureters, and bile ducts during surgery. The study involves adults aged 18 and older who are undergoing certain surgical procedures, su…

This observational study follows 1,222 adults with liver cirrhosis to understand why some develop serious complications like fluid buildup or bleeding. Participants have check-ups every six months, including questionnaires, physical exams, and imaging. The goal is to build better…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…