Cholangitis

This study tests whether upadacitinib, a drug already approved for eczema, can help people who have both atopic dermatitis (a type of eczema) with moderate to severe itching and a hard-to-treat autoimmune liver disease called cholangitis. The drug works by blocking a pathway invo…

This trial tests whether a procedure called EUS-guided gallbladder drainage can prevent future gallbladder attacks in people who are too sick or frail for surgery. Participants are randomly assigned to receive either the drainage procedure or standard medical care. The study will…

This phase 2 trial tests whether ursodeoxycholic acid (UDCA), a drug already used for other liver conditions, can treat cholestatic hepatitis—a liver inflammation caused by immunotherapy—better than standard steroids. About 94 adults with cancer (excluding liver cancer) who devel…

This study will follow 220 patients with benign gallbladder diseases who cannot have surgery. It compares two non-surgical approaches: endoscopic drainage with possible stone removal versus traditional drainage alone. The goal is to see which method leads to fewer complications a…

This study tests whether oral vancomycin, an antibiotic, can help children aged 6-15 with inflammatory bowel disease (IBD), especially types linked to liver problems. About 140 kids will either get vancomycin plus standard care or standard care alone for up to a year. Researchers…

This study tests whether transplanting gut bacteria from healthy donors can prevent repeat episodes of a serious bile duct infection called cholangitis. About 44 adults who have had at least two infections in the past year will receive either fecal transplants or standard care. T…

This study tests a drug called seladelpar in 10 adults who have bile duct damage (ischemic cholangiopathy) after a liver transplant. The goal is to see if the drug can improve liver enzyme levels and is safe. Participants will take the drug for 26 weeks and be monitored closely.

This study tests whether fecal microbiota transplantation (FMT) can improve liver function in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). 72 participants will receive either FMT or a sham procedure via colonoscopy and later oral capsules…

This pilot study tests whether the antibiotic vancomycin can safely treat active ulcerative colitis in adults who also have primary sclerosing cholangitis, a liver condition. Fourteen participants will take vancomycin or a placebo for 4 weeks, with an optional 4-week extension. T…

This study checks if a simpler way to collect blood samples works as well as the standard method for the HepQuant DuO liver test. The test involves drinking a natural substance and taking blood samples 20 and 60 minutes later. Researchers will compare different blood collection t…

This study tests whether a combined PET/MRI scan can detect and measure liver scarring (fibrosis) in people with primary sclerosing cholangitis (PSC). Ten participants will receive two experimental tracers that bind to scar tissue, and results will be compared to standard tests l…

This study tests whether a special yogurt containing the probiotic Pediococcus acidilactici GR-5 can help people with chronic cholecystitis (long-term gallbladder inflammation). Fifty adults with the condition will eat either the probiotic yogurt or a regular placebo yogurt daily…

This study compares two common pain relief techniques after laparoscopic gallbladder removal: local anesthetic injected into the surgical cuts versus an ultrasound-guided nerve block near the belly button. The goal is to see which method better reduces pain and the need for opioi…

This study tests whether a dye called indocyanine green (ICG), which makes bile ducts glow under special cameras, can reduce bile duct injuries and leaks during emergency gallbladder removal. About 296 adults with acute cholecystitis (inflamed gallbladder) will be randomly assign…

This study looks at whether warming the contrast dye to body temperature (37°C) before injecting it during an ERCP procedure can lower the chance of infection (cholangitis) in people with hilar cholangiocarcinoma (a type of bile duct cancer). About 100 adults aged 18-90 who need …

This study tests whether acupuncture at a specific point called Yanglingquan can quickly reduce pain from biliary colic, a sharp pain caused by gallstones. Researchers will compare it to standard drug therapy in 248 adults aged 18 to 65. The goal is to see if this traditional Chi…

This study tests whether giving lidocaine through an IV during gallbladder surgery can reduce inflammation and pain, and help the gut start working again sooner. 90 adults having planned laparoscopic gallbladder removal will be randomly assigned to receive either lidocaine or a p…

This study looks at how different rates of high-flow oxygen affect oxygen levels in the blood and brain during sedation for a bladder scope procedure (cystoscopy). About 200 adults will be randomly assigned to receive one of three oxygen flow rates while their breathing and oxyge…

This study will observe 1,500 adults with severe gallbladder inflammation caused by gallstones. Researchers will compare outcomes like recovery, survival, and hospital stay among patients treated with early surgery, drainage, or antibiotics alone. No new treatments are tested—doc…

This study will follow 1,000 adults who have liver or bile duct surgery at one hospital in Italy. Researchers will track complications, survival, and cancer recurrence for up to 5 years. The goal is to better understand what affects recovery and long-term health after these opera…

This study looks at 140 adults who need a plastic stent to open a blocked bile duct. If their bile has bacteria, they are randomly assigned to have the stent replaced after 1 month instead of the usual 3 months. The goal is to see if earlier replacement lowers the chance of the s…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will test whether robotic surgery can be used for emergency abdominal operations, such as for severe gallbladder infections or bowel blockages. The goal is to see if it's feasible and if it can lower complication rates and shorten hospital stays compared to traditional…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…