New drug trial targets debilitating itch in liver disease
NCT ID NCT04663308
Summary
This study is testing whether an investigational drug called volixibat can safely reduce the severe itching (pruritus) experienced by people with primary sclerosing cholangitis (PSC), a chronic liver disease. The trial involves 182 participants who will receive either the drug or a placebo to compare their itch levels and quality of life. Researchers will also check if the medicine has any effect on the underlying liver disease itself.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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A.O.U. Federico II
Naples, 80131, Italy
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APHP-Hôpital Saint Antoine
Paris, 75571, France
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ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Amsterdam UMC - VU Medisch Centrum (VUmc)
Amsterdam, 1081 HV, Netherlands
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Austin Health
Melbourne, 3084, Australia
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Azienda Ospedale Universita Padova
Padua, 35100, Italy
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Azienda Ospedaliero-Universitaria di Bologna - Policlinico S. Orsola-Malpighi
Bologna, 40138, Italy
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Bon Secours Liver Institution of Hampton Roads Mary Immaculate Hospital Office
Newport News, Virginia, 23603, United States
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CHU Bordeaux - Haut Lévêque
Pessac, 33600, France
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California Pacific Medical Center Research Institute
San Francisco, California, 94109, United States
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Cambridge University Hospitals NHS Foundation Trust - Addenbrooke's Hospital
Cambridge, CB2 0QQ, United Kingdom
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Carmel Medical Center
Haifa, 3434104, Israel
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Centre Hospitalier Universitaire De Lille
Lille, 59037, France
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Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes)
Grenoble, 38043, France
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Charité Universtitätsmedizin - Campus Virchow-Klinikum
Berlin, 13353, Germany
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
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Columbia University Medical Center - Presbyterian Hospital and Vanderbilt Clinic
New York, New York, 10032, United States
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Duke Health - Duke University Medical Center
Durham, North Carolina, 27710, United States
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Einstein Healthcare Network - Einstein Medical Center
Philadelphia, Pennsylvania, 19141, United States
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Erasmus University Medical Center
Rotterdam, 3015 GD, Netherlands
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Escola Bahiana de Medicina e Saude Publica
Salvador, 40290-000, Brazil
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Florida Research Institute
Lakewood Rch, Florida, 34211, United States
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Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Fondazione IRCCS San Gerardo dei Tintori
Monza, 20900, Italy
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Galen Medical Group
Hixson, Tennessee, 37343, United States
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Galilee Medical Center
Nahariya, 2210001, Israel
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Glenny Corp S.A.
Ciudad Autónoma Buenos Aires, C1430, Argentina
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Hadassah Medical Center - Ein Karem
Jerusalem, 91120, Israel
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Hannover Medical School
Hanover, Lower Saxony, 30625, Germany
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hillel Yaffe Medical Center
Hadera, 38100, Israel
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Hospital Clinic Barcelona
Barcelona, 08036, Spain
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Hospital Das Clinicas Da Ufg
Goiânia, 74535-170, Brazil
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Hospital El Cruce
San Juan Bautista, B1888, Argentina
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Hospital General Universitario Gregorio Maranon
Madrid, 28007, Spain
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Hospital Italiano de Buenos Aires
Buenos Aires, C1199, Argentina
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Hospital das Clinicas da UFMG
Belo Horizonte, 30140-080, Brazil
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Hospital de Clinicas de Porto Alegre
Porto Alegre, 90035-903, Brazil
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Hospital do Rim e Hipertensao
São Paulo, 04038-002, Brazil
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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John Radcliffe Hospital
Oxford, Headington, OX3 9DU, United Kingdom
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King's College Hospital NHS Foundation Trust
London, SE5 9RS, United Kingdom
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Liver Associates of Texas
Houston, Texas, 77030, United States
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Liver Institute Northwest
Seattle, Washington, 98105, United States
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Liverpool Hospital
Liverpool, 2170, Australia
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London Health Sciences Centre University Hospital
London, N6A 5A5, Canada
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Lothian NHS Board
Edinburgh, EH164SA, United Kingdom
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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McGill University Health Centre - Royal Victoria Hospital
Montreal, H4A 3J1, Canada
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McMaster University Hospital
Hamilton, Ontario, L8L 0A4, Canada
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MedStar Georgetown University Hospital
Washington D.C., District of Columbia, 20007, United States
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New York University Langone Health
New York, New York, 10016, United States
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Northern Health
Epping, VIC 3076, Australia
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Northwell Health
Manhasset, New York, 11030, United States
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Nottingham University Hospital NHS Trust
Nottingham, NG7 2FT, United Kingdom
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Otto-von-Guericke-Universitat Magdeburg
Magdeburg, 39120, Germany
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Rabin Medical Center
Petah Tikva, 4941492, Israel
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Radboud University Medical Centre (MC)
Nijmegen, 6525 GA, Netherlands
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Rambam Medical Center
Haifa, 3109601, Israel
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Richmond Community Hospital LLC
Richmond, Virginia, 23226, United States
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Royal Adelaide Hospital
Adelaide, 5000, Australia
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Royal Free Hospital
London, Hampstead, NW3 2QG, United Kingdom
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Royal Victoria Hospital
Belfast, BT12 6BA, United Kingdom
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Science 37, Inc (Remote-homebased Telemedicine)
Morrisville, North Carolina, 27560, United States
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Shaare Zedek Medical Center
Jerusalem, 9103102, Israel
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Sheba Medical Center
Ramat Gan, 52621, Israel
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Southern California Research Center
Coronado, California, 92118, United States
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Southern Therapy and Advanced Research LLC
Jackson, Mississippi, 39216, United States
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St James' University Hospital Leeds Teaching Hospitals NHS Trust
Leeds, LS9 7TF, United Kingdom
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St. Josefs-Hospital Wiesbaden
Wiesbaden, 65189, Germany
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Tampa General Hospital
Tampa, Florida, 33606, United States
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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The Liver Institute At Methodist Dallas Medical Center
Dallas, Texas, 75203, United States
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The Newcastle upon Tyne Hospitals NHS Foundation Trust - Royal Victoria Infirmary
Newcastle upon Tyne, NE1 4LP, United Kingdom
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The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada
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Universitaetsklinikum Bonn
Bonn, Nordrhine-Westphalia, 53127, Germany
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Universitaetsklinikum Erlangen
Erlangen, 91054, Germany
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Universitair Medisch Centrum Groningen
Groningen, 9713 GZ, Netherlands
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Universitair Ziekenhuis Antwerpen (UZA)
Ghent, 9000, Belgium
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Universitatsklinikum Leipzig
Leipzig, 04103, Germany
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University Health Network - Toronto General Hospital
Toronto, Ontario, M5G 2C4, Canada
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University Hospital Ghent
Ghent, 9000, Belgium
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University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
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University Hospital Tubingen Medical Clinic
Tübingen, 72076, Germany
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University Hospital Zurich
Zurich, 8091, Switzerland
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University Hospitals Birmingham NHS Foundation Trust - Wellcome Trust Birmingham Clinical Research Facility
Birmingham, B15 2TH, United Kingdom
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University of Alberta
Edmonton, Alberta, T6G 2R3, Canada
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University of Calgary
Calgary, T2N 4Z6, Canada
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University of California, Davis
Sacramento, California, 95817, United States
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University of Colorado - Anschutz Medical Campus
Aurora, Colorado, 80045, United States
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University of Miami - Schiff Center for Liver Diseases
Miami, Florida, 33136, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Rochester Medical Center - Strong Memorial Hospital
Rochester, New York, 14642, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Utah Health Care
Salt Lake City, Utah, 84132, United States
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University of Washington - Harborview Medical Center
Seattle, Washington, 98104, United States
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University of the Sunshine Coast
Sippy Downs, 4556, Australia
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Universitätsklinikum Schleswig-Holstein - Campus Kiel
Kiel, 24105, Germany
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
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Weill Cornell Medical College
New York, New York, 10021, United States
Conditions
Explore the condition pages connected to this study.