New hope for rare liver disease: drug trial targets bile duct damage
NCT ID NCT05627362
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called elafibranor in 68 adults with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. The main goal is to check the drug's safety and side effects compared to a placebo. Researchers will also look at blood tests to see if the drug helps slow the disease.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aberdeen Royal Infirmary NHS Grampian Grampian Health Board
Aberdeen, AB25 2ZD, United Kingdom
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Ambrose King Centre-Royal London Hospital-Barts Health NHS Trust
London, E1 1BB, United Kingdom
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American Research Corporation at The Texas Liver Institute
San Antonio, Texas, 78215, United States
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Aspen Woods Clinic
Calgary, T3H 0V5, Canada
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Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
Palermo, 90127, Italy
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Azienda Ospedaliera di Padova - U.O.C. di Gastroenterologia
Padova, 35128, Italy
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Azienda Ospedaliero Universitaria Modena
Modena, 41124, Italy
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Beth Israel Deaconess Medical Center, Liver Research Center
Boston, Massachusetts, 02215, United States
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Bon Secours Richmond Community Hospital LLC. d/b/a Bon Secours Liver Institute of Richmond
Richmond, Virginia, 23226, United States
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Brampton Civic Hospital (BCH) - Osler Hepatitis Centre
Brampton, Ontario, L6R 3J7, Canada
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Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
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Centre de Recherche du Centre Hospitalier de l'Universite de Montreal
Montreal, H2X 0A9, Canada
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Centro Hospitalar Universitario Lisboa Norte
Lisbon, 1345-035, Portugal
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Centro Hospitalar de Lisboa ocidental (CHLO), Hospital Egas Moniz
Lisbon, 1349-019, Portugal
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Centro Hospitalar do Alto Ave - Hospital Senhora da Oliveira
Guimarães, 4800-055, Portugal
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Charite Campus Virchow
Berlin, 13353, Germany
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Covenant Research
Sarasota, Florida, 34240, United States
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Frimley Park Hospital - Frimley Health NHS Foundation Trust
Frimley, GU16 7UJ, United Kingdom
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G.I Research Institute
Vancouver, V6Z 2K5, Canada
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Gastro Health Research
Cincinnati, Ohio, 45219, United States
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Gastro One
Cordova, Tennessee, 38018, United States
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Glasgow Royal Infirmary - Greater Glasgow Health Board
Glasgow, G4 0SF, United Kingdom
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Gruppo Humanitas - Humanitas Research Hospital, Istituto Clinico Humanitas
Rozzano, 20089, Italy
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Hospital De Montecelo
Pontevedra, 36071, Spain
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Hospital General Universitario Gregorio Maranon (HGUGM)
Madrid, 28007, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Puerta de Hierro
Majadahonda, 28222, Spain
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Hospital Universitario Rio Hortega
Valladolid, 47012, Spain
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Hospital Universitario Vall d'Hebron
Barcelona, 08035, Spain
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Hull Royal Infirmary - Hull University Teaching Hospitals NHS Trust
Hull, HU3 2JZ, United Kingdom
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Huron Gastroenterology Associates - Center for Digestive Care
Ypsilanti, Michigan, 48197, United States
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Intermountain Medical Center
Murray, Utah, 84107, United States
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Klinikum der Johann Wolfgang Goethe-Universitaet Frankfurt
Frankfurt, 60590, Germany
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Liver Institute Northwest
Seattle, Washington, 98105, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Mercy Medical Center
Baltimore, Maryland, 21202, United States
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New York University Langone Health
New York, New York, 06510, United States
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Om Research LLC
Lancaster, California, 93534, United States
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Ospedale Casa Sollievo della Sofferenza
San Giovanni Rotondo, 71013, Italy
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Peak Gastroenterology Associates
Colorado Springs, Colorado, 80907, United States
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Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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Piedmont Hospital - Piedmont Transplant Institute
Atlanta, Georgia, 30309, United States
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Queen Elizabeth Hospital
Birmingham, B15 2TT, United Kingdom
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Rocky Mountain Gastroenterology (RMG)
Littleton, Colorado, 80120, United States
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Schiff Center for Liver Diseases - University of Miami
Miami, Florida, 33136, United States
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South Denver Gastroenterology,P.C.
Englewood, Colorado, 80113, United States
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Southwest Gastroenterology Associates, PC (SWGA)
Albuquerque, New Mexico, 87109-4342, United States
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Sutter Health Van Ness Campus Medical Office Building
San Francisco, California, 94109, United States
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Tandem Clinical Research GI
Marrero, Louisiana, 70072, United States
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The Royal Free Hospital - Royal Free London NHS Foundation Trust
London, NW3 2QG, United Kingdom
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19017, United States
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Universitaetsklinikum Heidelberg - Nationales Centrum fuer Tumorerkrankungen
Heidelberg, 69120, Germany
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University Hospital Ulm
Ulm, 89081, Germany
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University Of Alberta Hospital-Zeidler Ledcor Centre
Edmonton, Alberta, T6G 2X8, Canada
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University Of Texas Southwestern Medical Center At Dallas
Dallas, Texas, 75235, United States
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University of Calgary
Calgary, Alberta, T2N 4Z6, Canada
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University of California, Davis
Sacramento, California, 95817, United States
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University of Nebraska Medical Center
Omaha, Nebraska, 68198, United States
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University of Virginia Medical Center
Charlottesville, Virginia, 22093, United States
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
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Yale University School Of Medicine - Yale Center For Clinical Investigation
New Haven, Connecticut, 06510, United States
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