Chemotherapy-induced neuropathy

This Phase 2 trial tests whether psilocybin, a psychedelic compound, can prevent or lessen chemotherapy-induced peripheral neuropathy (nerve damage) in people with breast, colorectal, or head and neck cancer. About 83 participants will receive either psilocybin, a low-dose placeb…

This study tests whether electroacupuncture (using mild electric pulses on needles) plus tiny thumbtack needles can prevent nerve damage caused by chemotherapy in people with early-stage cancer. About 278 patients with breast, stomach, bowel, lung, or ovarian cancer will receive …

This study tests whether electroacupuncture (acupuncture with mild electrical pulses) combined with tiny thumbtack needles can prevent peripheral neuropathy—numbness, tingling, or pain—caused by chemotherapy in people with advanced cancer. The trial enrolls adults with stage IV b…

This study tests a simple idea: wearing tight surgical gloves during paclitaxel chemotherapy might prevent nerve damage in the hands. About 84 breast cancer patients will be randomly assigned to either wear the gloves during treatment or receive standard care. Researchers will th…

This study tests whether two existing drugs—memantine (used for Alzheimer's) and rosuvastatin (a cholesterol-lowering statin)—can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. About 46 adults will receive these drugs alongside …

This study tests whether wearing tight compression garments on hands and feet during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by taxane or oxaliplatin drugs. About 358 breast and colorectal cancer patients will be randomly assigned to wear compression …

This study tests whether the supplement glutamine can prevent nerve damage caused by the chemotherapy drug vincristine in children and teens with cancer. About 70 participants, aged 6 to 18, will take glutamine twice daily for 14 days during their treatment. Researchers will trac…

This phase 3 trial tests whether a homeopathic remedy called Stibium metallicum praeparatum 6x can prevent or reduce nerve damage caused by the chemotherapy drug paclitaxel. The study will include 120 breast cancer patients who will receive either the remedy or a placebo injectio…

This study tests whether wearing a tight surgical glove on one hand during chemotherapy can prevent nerve damage (peripheral neuropathy) in breast cancer patients. 44 participants will wear a smaller glove on their dominant hand during each chemo session, while the other hand ser…

This trial investigates whether photobiomodulation (low-level laser light) can reduce early nerve damage caused by chemotherapy. About 98 cancer patients with early signs of peripheral neuropathy will receive either light therapy or a placebo. The goal is to see if this non-invas…

This trial tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help cancer survivors with chemotherapy-induced peripheral neuropathy (CIPN). CIPN causes numbness, tingling, pain, and movement problems. The study compa…

This study tests whether a traditional Chinese medicine formula, Wenyang Tongbi Granules, can reduce nerve pain and numbness caused by chemotherapy. 144 adults with breast or colorectal cancer who develop hand-foot tingling or pain during chemo will receive either the herbal gran…

This early-phase study tests a new tablet, JMKX000189, in 18 adults with cancer who have nerve pain or numbness from chemotherapy. The main goal is to check safety and side effects, while also seeing if the drug can reduce pain and numbness. Participants must have solid tumors an…

This study tests whether a spinal cord stimulator can reduce chronic nerve pain caused by chemotherapy. 68 adults with pain lasting over a year will have the device implanted and then randomly receive either active or sham stimulation. The goal is to see if active stimulation pro…

This study tests whether papaverine, a drug that relaxes blood vessels, can relieve nerve pain and numbness caused by taxane chemotherapy. About 43 adults whose symptoms haven't improved with standard treatments will receive daily infusions of papaverine for up to three weeks. Th…

This study tests whether a program combining exercise and mindfulness-based therapy can reduce nerve pain and emotional distress in cancer patients who have nerve damage from chemotherapy. About 40 adults with early-stage cancer and chemotherapy-induced peripheral neuropathy will…

This study tests whether standing on a vibrating platform (whole body vibration) for 15 minutes, three times a week for eight weeks, can improve balance, reduce fear of falling, and enhance quality of life in people with nerve damage from chemotherapy. Thirty adults aged 30-60 wi…

This study looks at whether ziconotide, a drug given through a pump in the spine, can reduce nerve pain caused by chemotherapy. Researchers will track pain levels and daily function in 24 adults over 24 months. The goal is to see if this already-approved pain treatment can help p…

This study tests whether hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—can reduce nerve pain and numbness caused by the chemotherapy drug nab-paclitaxel in breast cancer patients. About 160 women who have finished chemo and developed nerve symptoms will…

This study tests if taking fish oil by mouth can prevent or lessen nerve damage (peripheral neuropathy) caused by the chemotherapy drug bortezomib in people with multiple myeloma. Researchers will compare nerve health in 200 patients who take fish oil versus those who don't. The …

This study looks at whether exercise can lessen nerve damage caused by certain chemotherapy drugs. About 140 people with colorectal or gynecologic cancer will either exercise or receive usual care. Researchers will measure nerve function, blood markers, and quality of life to see…

This study tests if a special balance training program can help cancer patients who have numbness, tingling, and walking problems caused by chemotherapy. 70 adults aged 30-60 with breast, rectal, or stomach cancer will be randomly assigned to either standard physical therapy or s…

This study looks at whether taking magnesium by mouth or soaking feet in a magnesium solution can help colorectal cancer patients who are on chemotherapy. The goal is to see if these simple treatments can reduce nerve damage (pain, tingling) and improve sleep quality. About 75 ad…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests if a gentle, non-invasive electrical stimulation on specific acupoints can reduce nerve pain caused by chemotherapy in children aged 10-17 with acute lymphoblastic leukemia. The treatment is given for 8 weeks, and researchers will check if it helps with pain, mov…

This study compares an 8-week versus a 12-week supervised exercise programme in 50 colorectal cancer patients receiving chemotherapy. The goal is to see if exercise can reduce chemotherapy-induced peripheral neuropathy—nerve damage causing tingling, numbness, and pain—and improve…

This study tests whether gentle electrical stimulation on acupoints or acupressure on the ear can reduce nerve pain caused by chemotherapy in children with leukemia. 132 children aged 8-17 will be randomly assigned to one of three groups: electrical stimulation, acupressure, or s…

This study tests a 3-month exercise program for women with breast cancer who have arm swelling (lymphedema) and nerve pain (neuropathy) from treatment. Thirty women will do general and arm-specific exercises twice a week. Researchers will measure changes in arm size and pain leve…

This study tests a home-based tele-rehabilitation program for people who have thinking and movement problems after chemotherapy. Sixty adults who finished chemo will be split into two groups: one gets 15 sessions of personalized cognitive and motor exercises via a tablet and remo…

This study looks at 70 adults with sensory neuronopathy, a rare nerve condition that causes balance and coordination problems. Researchers will test several clinical scales over 12 months to see which one best tracks how the disease changes over time. The goal is to find a reliab…

This study aims to find blood markers that can predict which cancer patients will develop chronic nerve pain from chemotherapy. Researchers will collect blood samples and perform neurological exams on 192 patients over 6 months. The goal is to use this information to personalize …

This study looks at how chemotherapy for breast cancer affects the sense of arm position (proprioception). Researchers will compare three groups: breast cancer patients who had chemotherapy, those who had surgery only, and healthy volunteers. Using robotic tasks and video trackin…

This study will assess physical function in 80 people with chemotherapy-induced peripheral neuropathy (CIPN) using tests like balance, walking, and grip strength. Researchers will compare these objective measures with patients' own symptom reports to develop better ways to track …

This study will follow 100 newly diagnosed breast cancer patients in Egypt to see how chemotherapy affects their thinking, memory, and nerves. Researchers will use questionnaires and exams before treatment and one year later. The goal is to better understand these side effects in…