Cerebral palsy

This study compares two treatments—special exercises called PNF and music therapy—to see which helps children with ataxic cerebral palsy improve balance, coordination, and daily activities. About 29 children aged 6 to 18 will take part, receiving either PNF or music therapy along…

This trial tests whether a 12-week program of core stabilization exercises can improve balance, trunk control, and gross motor function in children with spastic diplegic cerebral palsy. Sixty children who can walk with some assistance will be randomly assigned to receive either s…

This early-stage trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and practical for young children with cerebral palsy. The study will enroll about 7 children aged 2 to 5 with moderate to severe motor impai…

This trial tests whether giving the immunotherapy drug durvalumab before surgery can help women with early, small triple negative breast cancer. Participants receive two infusions of durvalumab, then either proceed to surgery or, if needed, additional standard therapy. The study …

This trial tests whether structured eye-movement exercises can improve balance and motor skills in children aged 6 to 10 with spastic diplegia, a form of cerebral palsy. Participants perform exercises like tracking moving targets and shifting gaze quickly, alongside standard phys…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This study tests whether adding robot-assisted walking training to standard physical therapy helps children with cerebral palsy move better and breathe easier. Twenty-four children aged 8-18 will receive either standard therapy alone or standard therapy plus robotic walking sessi…

This study tests whether stem cells from donated umbilical cords can improve movement and thinking in children with cerebral palsy. 78 children aged 6 months to 3 years will receive either stem cells plus a special liquid (conditioned medium), stem cells alone, or standard therap…

This study tests whether a remote physiotherapy program, based on the neurodevelopmental treatment (Bobath) model, can improve gross motor skills and daily function in children with cerebral palsy. Twenty children aged 6 months to 6 years will participate, with a caregiver helpin…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study gave stem cell infusions to one person with severe cerebral palsy who had no other treatment options. The goal was to improve their quality of life, not to cure the condition. The person received 8 infusions of their own stem cells, taken from fat tissue.

This study compares two types of physical therapy for children aged 6 to 10 with diplegic cerebral palsy: scooter board activities and core stability exercises. The goal is to see which better improves trunk control and balance. Forty children will participate, and their progress…

The GMFCS sorts children with cerebral palsy into five levels of gross motor function, largely based on two visible things: whether an adult physically helps the child move, and whether the child bears weight on an external object like a walker or furniture. Scoring these cues ta…

This study explores whether a new screening procedure can detect cerebral palsy (CP) earlier in high-risk infants using video recordings and artificial intelligence. Traditionally, CP is diagnosed between 12 and 24 months of age, but earlier detection could lead to better outcome…

This trial tests whether adding Therapeutic Listening, a music-based auditory therapy, to a standard exercise program improves balance, trunk control, and reaction time in children with spastic diplegic cerebral palsy. Sixty children will receive either exercise alone or exercise…

This pilot study tests whether virtual reality games or functional strength training can improve arm function in children with cerebral palsy. Ten participants will be randomly assigned to one of two home-based interventions, each lasting six weeks. Researchers will measure chang…

This study tests a 6-8 week running program adapted for children with mobility challenges like cerebral palsy. The program uses a special device called a RaceRunner to help kids participate. Researchers will measure endurance, speed, and heart rate to see if the program improves …

This trial tests whether adding a robotic glove to mirror therapy can improve arm and hand function in children with hemiparetic cerebral palsy. Participants will receive either robot-assisted or conventional mirror therapy alongside standard neurodevelopmental treatment for six …

This pilot study tests whether a home-based training program using joystick-operated ride-on toys can help children aged 3-8 with hemiplegia improve arm function. Children will use their affected arm to drive the toy through playful challenges, compared to a creative upper extrem…

This study tests whether a mild electrical current applied to the scalp, called transcranial direct current stimulation (tDCS), can enhance motor learning in children with unilateral spastic cerebral palsy. Participants aged 6 to 17 will receive tDCS or a sham during five days of…

This study tests whether a structured walking therapy program can improve mobility in 120 adolescents and young adults with cerebral palsy. Participants undergo 24 gait training sessions over 8 weeks, with before-and-after tests of walking speed, brain activity, and muscle contro…

This study aims to see if behavioral coaching, using wearable activity monitors, can help people with cerebral palsy increase their daily steps and improve mobility. Researchers will track changes in walking speed, balance, and brain activity in 32 participants. The goal is to fi…

This trial tests whether a special training program called Reactive Functional Motor Challenge Training can improve dynamic balance and functional mobility in children with spastic diplegic cerebral palsy. The training uses equipment like balance pads, cones, therapy balls, and a…

This pilot study explores whether robot-assisted walking devices can be used in schools to help children who cannot walk independently. The devices attach to a walker and power leg movements, allowing children to stand and walk upright. The study aims to identify the best ways to…

This study compares a special exercise program called Coordinative Locomotor Training (CLT) to regular physiotherapy for children aged 8 to 12 with spastic hemiplegic cerebral palsy, a condition that causes stiffness on one side of the body. CLT uses running and skating movements…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests whether augmented reality (AR) games can improve walking and balance in children with cerebral palsy. Forty children will either do exercises wearing AR goggles or receive standard physical therapy. The goal is to see if the AR approach is more effective and enga…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This study tests whether personalized nutrition advice can improve nutrition, reduce stomach problems, and enhance quality of life in children with cerebral palsy. Fifty children aged 6 to 12 will be randomly assigned to receive either individualized dietary counseling or routine…

This study looks at whether a very mild, unnoticeable electrical stimulation to the legs can help children and young adults with cerebral palsy (ages 10–21) maintain balance during everyday movements like standing up, walking, and turning. Participants will perform simple tasks w…

This study tests whether adding a mild electrical stimulation to the diaphragm (the main breathing muscle) can improve lung function, head control, and sitting balance in children with severe cerebral palsy who cannot walk. Thirty children aged 5-18 will receive either standard r…

This study compares robotic exoskeleton training to traditional physical therapy for improving walking in adolescents and young adults with cerebral palsy. Participants undergo brain scans, mobility tests, and nerve tests before and after training. The goal is to see if the robot…

This small study tests whether adding robot-assisted walking training to regular physiotherapy can improve body composition (like muscle and fat) and daily function in children with cerebral palsy or similar conditions. Nine children will each receive both standard physiotherapy …

This study looks at whether using a passive kinesiotherapy device on the legs for 30 minutes can immediately reduce muscle stiffness (spasticity) and improve walking in people with conditions like cerebral palsy, stroke-related weakness, or spinal cord issues. About 80 participan…

This trial tests a robotic exoskeleton called the CPWalker to help children with cerebral palsy improve their walking. The device supports the child's weight and assists leg movements during walking practice. The study includes 30 participants aged 11 to 21 with spastic diplegia.…

This study tests whether 3 months of intensive leg exercise (walking, kicking, jumping, and climbing with small ankle weights) can improve walking and daily function in 60 young children with spastic diplegia caused by prematurity. The exercise is done 1 hour a day, 4 days a week…

This study looks at the cost and benefits of a two-week day camp for children with mild to moderate arm weakness (hemiparesis) from cerebral palsy or brain injury. In the first week, children wear a constraint on their stronger arm to encourage use of the weaker arm, followed by …

This study tests whether online group cognitive behavioral therapy (CBT) is a practical way to help adults with cerebral palsy who have chronic pain. Fourteen participants will attend weekly virtual therapy sessions for 12 weeks. The main goal is to see if people will stick with …

This study tests a gentle hands-on technique called Strain Counter-Strain to relax tight jaw and neck muscles in 30 children with spastic cerebral palsy, ages 4 to 8. The goal is to improve mouth opening, reduce drooling, and make eating easier. Results are measured after one mon…

This study compares two types of therapy for children aged 8 to 12 with spastic diplegic cerebral palsy. One group uses play-based activities like puzzles and arts and crafts, while the other uses standard exercises with resistance bands and weights. The goal is to see which appr…

This study tests whether an 8-week power wheelchair training program using the IndieTrainer system can help children with severe cerebral palsy improve their wheelchair skills and independence. Sixteen children who cannot walk or propel a manual wheelchair will participate. The t…

This study tests a program called MSE-PEACE, where parents and children with developmental disabilities (like autism or ADHD) attend 10 sensory sessions together. The goal is to see if it improves children's engagement and emotional control, and helps parents feel more confident …

This study compares two physical therapy approaches for children aged 8-24 months with or at high risk for cerebral palsy. One method focuses on sitting, reaching, and problem-solving, while the other targets general motor skills. The goal is to see which therapy improves sitting…

This study looks at whether walking on a path with lights that show where to step can improve how children with spastic diplegia (a type of cerebral palsy) walk. Thirty children aged 5 to 8 with mild spasticity will walk on the light pathway, and researchers will measure changes …

This study tests an intensive group physical therapy program for children aged 7-17 with cerebral palsy who can walk. The program focuses on improving muscle strength, walking speed, and daily activities like climbing stairs. Researchers will measure changes in strength, balance,…

This study tests a 12-week play-based training program for children aged 2-5 with cerebral palsy. The program uses running frames and other assistive devices to improve mobility, fitness, and daily activity. Twenty children will participate in weekly group sessions plus home exer…

This study looks at whether doing arm exercises on a vertical surface (like a wall) or a horizontal surface (like a table) makes a bigger difference in hand skills and trunk control for children with bilateral cerebral palsy. Thirty children aged 5 to 8 will take part in a 3-mont…

This study compares two ways of delivering an intensive upper limb therapy program for children with cerebral palsy, ages 3 months to 4 years 11 months, and their caregivers. The goal is to see which method works better for improving hand function. The study involves 37 children …

This study looks at whether adding music to standard occupational therapy can help children aged 5-12 with conditions like cerebral palsy, encephalitis, or brain tumor recovery. Researchers will measure changes in walking, balance, and vital signs like heart rate and oxygen level…

This study tests a wearable robotic exoskeleton called EXPLORER in 15 children with movement problems from conditions like cerebral palsy. The goal is to see if it helps them walk better in their everyday environments, such as home and the community. The study focuses on safety, …

This study tests a training program that teaches children with physical disabilities how to use their manual wheelchairs better. The goal is to help them move around on their own instead of relying on others, which can improve their confidence and social life. Four children aged …

This study tests a robotic feeding device called Obi for people who cannot use their arms to eat on their own. About 50 participants, including patients, caregivers, and healthcare providers, will use the device at home or in care settings for one week. Afterward, they will fill …

Researchers are studying the natural fidgety movements of infants to see if these movements can help predict cerebral palsy and other developmental issues. They will follow 350 babies, including healthy full-term infants and those at higher risk due to medical conditions, trackin…

This study explores how children with bilateral cerebral palsy (a condition affecting movement on both sides of the body) step, by adding or reducing body weight during walking tasks. Researchers will measure joint movements, forces, and muscle activity to understand lower limb i…

This study explores why some people with cerebral palsy respond well to gait training while others do not. Researchers will track brain activity and walking ability weekly during an 8-week physical therapy program in 20 participants. The goal is to identify brain patterns that pr…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This study looks at how the brain and spinal cord work together in people with cerebral palsy compared to those without. Researchers will use brain scans and simple tasks to measure these signals. Some participants will also receive a mild electrical current over the scalp or spi…

This study follows 72 adults with cerebral palsy who had walking tests as children to see how their walking ability changes over time. Researchers measure joint movement, muscle activity, and blood markers related to metabolism and inflammation. The goal is to understand how walk…

This study tests a new way to measure how children move their arms using a special camera system that tracks reflective markers placed on the skin. Researchers will check if the method is reliable and easy to use in both healthy children and those with arm movement problems. The …

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study checks whether a play-based test of arm and hand movements, called the Melbourne Assessment-2, is reliable when done through telehealth for children with hemiplegic cerebral palsy. About 35 children ages 2 to 10 will attend one in-person visit and one telehealth visit,…

This study explores why constipation is common in children with cerebral palsy and what factors might be involved, such as diet, physical activity, and caregiver stress. Researchers will observe 100 children aged 4 to 18 and their caregivers using questionnaires and diaries. No t…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study looks at why people with cerebral palsy often feel very tired. Researchers will use EEG and PET scans to compare brain activity in 50 adults with mild versus severe fatigue. The goal is to find a brain network linked to fatigue, which could lead to better treatments in…

This study looks at whether a power wheelchair that can lift a child from sitting to standing is practical for kids with conditions like cerebral palsy, spinal cord injuries, or genetic diseases. Only 4 children aged 5-17 are taking part. The goal is to see if the chair helps the…