Cerebral artery stenosis

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This study tested a special stent designed to open severely narrowed brain arteries in 194 people with symptomatic intracranial atherosclerosis. The goal was to see if the stent is safe and effective at keeping arteries open for at least 12 months. Researchers measured how often …

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study tested whether adding sodium sivelestat, a drug that reduces inflammation, to standard mechanical thrombectomy could improve outcomes in 20 stroke patients with large vessel occlusion. The drug aims to prevent 'futile recanalization,' where blood flow is restored but p…

This study tested whether giving the blood-thinning drug tirofiban after mechanical clot removal improves outcomes for people with severe stroke. Over 1,300 participants were randomly assigned to receive tirofiban or a placebo. The goal was to see if more patients could live inde…

This study tested whether Enhanced External Counterpulsation (EECP) therapy, a non-invasive treatment using leg cuffs to boost blood flow, can improve brain circulation in people with severe narrowing of key brain arteries. The 130 participants had recently experienced a stroke o…

This study looked at whether raising the head after a stroke procedure helps patients recover better. Over 1,300 adults with severe strokes were followed for 90 days to see if head elevation improved their ability to function. The goal was to find a simple, low-cost way to boost …

This study tested a computer program called Heuron CTA that looks at brain CT scans to find large blockages in blood vessels. Researchers compared the software's results to diagnoses made by medical experts using scans from 270 adults. If accurate, this tool could help doctors di…

This study looked at whether a panel of blood biomarkers can quickly identify stroke patients who have a large vessel occlusion (a major blockage) and would benefit from a specialized clot-removal procedure. Researchers enrolled nearly 3,900 adults with stroke symptoms and tested…

This study tested whether a special type of MRI, called high-resolution vessel wall imaging, can help predict if a stroke will happen again in people with a narrowed brain artery. Researchers followed 74 patients who had a stroke or mini-stroke and received artery-opening treatme…

This study tested a 12-item checklist used by nurses to predict neurological complications like bleeding or re-blockage after endovascular therapy for stroke or aneurysms. Researchers compared 213 patients who were checked with the list to 213 who received standard care. The goal…

This completed observational study followed 3,849 people with asymptomatic intracranial atherosclerosis (narrowing of brain arteries) to better understand how the disease progresses and to improve stroke prediction. Participants underwent routine imaging and cognitive tests over …