Bone sarcoma

This early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…

This study tests a procedure called pulmonary suffusion, which delivers the chemotherapy drug cisplatin directly to the lungs through a minimally invasive method. The goal is to control any remaining cancer cells after surgery or ablation in patients with sarcoma or colorectal ca…

This early-phase trial tests a new treatment called attIL12-TIL for people with advanced or metastatic soft tissue and bone sarcoma. The therapy uses a patient's own tumor-fighting immune cells, modified to better target and attack cancer. The study first finds a safe dose, then …

This study tests whether giving targeted radiation to cancer that has spread (metastasized) can help children, teens, and young adults with sarcoma live longer. About 70 participants with soft tissue or bone sarcoma will receive consolidative radiation therapy to their metastatic…

This phase 2 trial tests a daily oral drug called zanzalintinib in 70 adults with advanced or metastatic bone sarcomas that cannot be removed by surgery. The study includes four groups based on sarcoma type. Researchers will check if the drug is safe and helps control the cancer.

This study tests a drug called zanzalintinib (XL092) in 29 people with advanced leiomyosarcoma that has spread or cannot be removed by surgery. The drug works by blocking signals that help cancer cells grow. The goal is to see if it can slow the cancer's progression longer than c…

This study looks at whether giving patients with bone or soft tissue sarcoma a special nutritional supplement twice daily before surgery can reduce complications and help maintain muscle mass. About 100 adults scheduled for tumor removal will be randomly assigned to receive eithe…

This study compares three treatments for pelvic sarcomas (cancers in the pelvic bone): carbon ion therapy, surgery (often with radiation), and proton therapy alone. Researchers want to see which approach gives patients better quality of life and controls the cancer best. About 72…

This study tests whether the drug regorafenib can help prevent bone sarcomas from coming back after initial treatment. About 168 people aged 12 and older with various bone sarcomas will be randomly assigned to take regorafenib for up to 12 months or to receive standard monitoring…

This phase 2 trial tests whether the drug regorafenib can help keep high-grade bone sarcomas from growing in patients who still have some disease after standard treatment. About 36 people aged 12 and older will take regorafenib daily for up to 12 months. The main goal is to see h…

This study tests a new combination of drugs for people with advanced bone or soft tissue sarcomas that have worsened after initial treatment. The combo includes a safer form of paclitaxel, standard chemotherapy, and a targeted therapy chosen based on tumor type. About 46 particip…

This early-phase study tests a technique called in vivo lung perfusion (IVLP) that delivers chemotherapy directly into the lung during surgery to remove sarcoma tumors that have spread to the lungs. The goal is to kill any tiny cancer cells left behind that could cause the cancer…

This study tests whether a dye called indocyanine green can help surgeons see if any cancer remains after removing a sarcoma. About 50 adults with bone or soft tissue sarcoma will receive the dye during surgery, and the surgeon will check for glowing areas that might indicate lef…

This study tests whether a personalized exercise program can improve physical function and quality of life in adolescents and young adults who have survived sarcoma. Participants first complete a triage tool to assess their needs, then receive a 12-week exercise plan that may inc…

This study looks at whether giving sarcoma patients early access to mental healthcare before and after surgery can help with depression, anxiety, and quality of life. About 60 adults with bone or soft tissue sarcoma who are scheduled for surgery at Memorial Sloan Kettering will t…

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study looks at the financial stress that patients with bone or soft tissue sarcoma face after surgery. Researchers will ask 100 adults to fill out questionnaires about the costs of their cancer care and how that affects their quality of life. No new treatments are being test…

This study is testing whether a blood test can find tiny bits of tumor DNA in people with sarcoma, a rare cancer of bone or soft tissue. Researchers will take blood samples before, during, and after treatment to see how well the test works. The goal is to learn if this liquid bio…

This study looks at how well children walk after having surgery for bone or soft tissue cancer in their legs. Researchers will use 3D cameras, muscle sensors, and wearable devices to measure movement in 300 children, comparing them to healthy kids of the same age. The goal is to …

This study looks back at 150 patients who had surgery to replace the upper thigh bone after removing a bone tumor. Researchers will check medical records and scans to see how long the reconstruction lasts and how well patients can move afterward. The goal is to learn what affects…

This study follows 300 people who had surgery to remove bone tumors (like osteosarcoma or chondrosarcoma). Researchers want to see how well the bone heals and how much function returns over 3 years. Participants fill out questionnaires about their daily activities. No new drug or…

This study looks at how people move and feel after surgery for bone or soft tissue sarcoma in the leg. Researchers will measure physical function, quality of life, and activity levels in 60 adults who had limb-saving surgery at least one year ago. The goal is to learn more about …

This registry is collecting information from up to 9,000 people in Germany with sarcoma or carcinosarcoma. Researchers will track how often different subtypes occur, how they progress, and what treatments patients receive. The goal is to better understand these rare cancers and i…

This early-phase trial is testing two new antibody fragments that are designed to attach to a sugar molecule found on many solid tumors. The fragments are labeled with a radioactive tracer so they can be seen on PET/CT scans. The study aims to see where these fragments go in the …

This study is testing whether a smartphone app can help track recovery in 800 sarcoma patients after surgery. Participants will fill out questionnaires and have their phone passively monitor steps, stairs, and other mobility data for up to a year. The goal is to see if this digit…

This study is developing a new way to deliver chemotherapy directly to sarcoma tumors using tiny particles activated by light through an optic fiber. Researchers will test these nanoparticles on cells and tissue samples from 30 patients with bone or soft tissue sarcomas. The goal…