Amphetamine abuse

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested a web-based addiction treatment program that was culturally adapted for American Indians and Alaska Natives. 53 adults in outpatient treatment used the program for 12 weeks. The goal was to see if it helped them stay away from drugs and alcohol and to decide if …

This study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use dis…

This study tested a mobile app designed to help gay and bisexual men reduce their methamphetamine use and risky sexual behaviors. The app includes games, lessons, and resources. 226 men who use meth took part. The goal was to see if the app could help them cut back on meth and lo…

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone therapy reduce methamphetamine use and improve HIV outcomes. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to sup…

This study tested a mindfulness program designed for women in residential treatment for substance use disorders. The program, called Mindfulness-Based Relapse Prevention for Women (MBRP-W), teaches stress management skills to help women stay in treatment and avoid relapse. Resear…

This study tested whether peer recovery coaches in emergency departments can help people with substance use disorders connect to treatment and support. 144 adults were randomly assigned to get in-person coaching, coaching via video call, or just a list of resources. Researchers f…

This study tested whether giving caregivers prize draws for attending court hearings, treatment sessions, and probation meetings could reduce substance use and delinquency in teens already in juvenile drug court. Fifty-three teens aged 13-17 and their caregivers took part. The go…

This study tested a new way to stimulate the brain in people addicted to amphetamines. Nine adults received closed-loop transcranial alternating current stimulation (tACS), which adjusts the stimulation based on their real-time brain activity. The goal was to improve executive co…

This study tested a digital pill and smartphone app to help people with substance use disorders take their HIV prevention medication (PrEP) consistently. Thirty HIV-negative men who have sex with men and have moderate to severe substance use disorder participated. They used a dig…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study tested a program called PRE-FAIR to prevent opioid and methamphetamine addiction in young parents (ages 16-30) already involved with Oregon's child welfare system. 240 parents who were at risk but not yet addicted were randomly assigned to either the PRE-FAIR program o…

This small pilot study tested an 8-week mindfulness and meditation program in 3 adults with substance use disorders. Participants reported lower stress and improved mindfulness after the program. One person stayed sober long-term, while two relapsed within a year. The study shows…

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids. 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress and depression, and preve…

This study tested whether a digital mindfulness app is practical and acceptable for people in early recovery from substance use disorders. 36 participants were randomly assigned to standard group therapy alone or standard therapy plus the app for 8 weeks. The main goal was to see…

This study tested a type of group therapy called Resilience-Oriented Therapy (RoT) for adults in Rwanda who were struggling with mental health issues like trauma, depression, anxiety, or anger. 427 people took part, and the therapy was tailored to each person's main problem, such…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This study tested a brain stimulation technique called closed-loop tACS in 21 people with methamphetamine addiction. The device uses brain wave patterns to deliver targeted electrical stimulation aimed at reducing cravings. Researchers measured craving levels and impulse control …

This study tested whether adding a personalized therapy scale to standard treatment helps reduce cravings in people with substance use disorders or behavioral addictions like gambling. 151 adults seeking outpatient care participated. The approach aimed to tailor treatment to each…

This study tested two remotely delivered programs—mindfulness-based cognitive therapy and internet-based cognitive behavioral therapy—against standard remote monitoring alone for reducing depression and substance use related to COVID-19 stress. 113 adults from a health system par…

This study tested a breathing and meditation program called SKY Recovery in 100 people recovering from substance use disorder at a residential center. Participants either took the program right away or after a delay. Researchers measured changes in emotion regulation, cravings, a…

This study looked at whether an online cognitive behavioral therapy program, called Breaking Free Online, helps people with substance use disorder cut back on their drug or alcohol use. About 200 adults from an outpatient addiction program took part. Some got standard care with g…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study tested whether providing overnight infant care and parenting support helps new mothers with substance use disorder living in residential treatment programs. 41 mothers participated, and researchers measured how many enrolled, completed the program, and gave feedback. T…

This study looked at whether a gentle brain stimulation technique called tACS can improve cognitive problems like memory and attention in people recovering from methamphetamine addiction. Researchers tested 68 participants using thinking tests, brain wave recordings, and blood sa…

This study aims to create and improve cognitive tasks used during functional MRI scans to better understand how drugs affect the brain. It involves 525 healthy volunteers, including both drug users and non-users, aged 18 to 65. Participants perform tasks like memory tests or reac…

This study tests whether recalling a positive memory can improve mood and decision-making in 80 adults recovering from methamphetamine use disorder. Participants will do computer tasks and brain scans before and after remembering a happy event or a neutral memory. The goal is to …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked back at the records of 652 patients who were seen in the emergency department of a French hospital and then referred to a special addiction liaison team. The goal was to understand the social and medical backgrounds of these patients. The findings could help hos…

This study tested whether a mobile app could help people on probation or parole who are receiving treatment for substance use disorder. 31 adults used the app alongside their usual care. Researchers measured how easy the app was to use and how satisfied participants were with it.

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This study tested a program called CRAFT-EP, which helps families support a relative with early psychosis and substance use (like alcohol or cannabis). The program was delivered entirely through video calls. Researchers measured family members' depression and anxiety to see if th…

This study looked at whether a questionnaire called the Behavioral Activation for Depression Scale (BADS) is a good tool for measuring depression-related behaviors in people with substance use disorders. Researchers analyzed answers from 289 adults receiving treatment for substan…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested a Spanish-language electronic screening tool called TAPS-ESP to identify tobacco, alcohol, prescription drug, and illicit substance use in primary care. About 1,000 Spanish-speaking adults from a clinic participated. The goal was to see if the tool accurately de…

This study tested a new way to help addiction treatment clinics use an AI platform that coaches counselors in evidence-based techniques. Researchers worked with 479 leaders and staff from state agencies and clinics in Oregon and Indiana. The goal was to see if this strategy impro…

This completed study worked with 65 African American/Black adults who use cocaine or other illicit substances to develop a manual called I-DREM. The goal was to gather their feedback on how to improve recruitment and retention in substance use disorder clinical trials. Participan…

This early-phase trial tested the safety of a new drug called CS-1103 in 32 healthy adults. Researchers gave single doses by IV to see if it causes side effects and how the body processes it. The goal is to gather basic safety information before testing it in people with methamph…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested whether combining a policy change with professional training can reduce stigma toward substance use in mental health clinics. Twelve providers from two sites participated. The goal was to see if the combined approach improves how often substance use is addressed…

This study tested an educational program designed to improve teenagers' knowledge and behavior around substance abuse. The program used a model called the Behavior Change Wheel to guide learning. Researchers worked with 226 adolescents aged 10 to 18 who had not received similar e…