University Of Pittsburgh

This study tests whether adding Air Quality Index (AQI) information to standard asthma action plans helps children control their asthma better. About 351 children with asthma will receive either EPA-AQI, commercial AQI, or standard education, and their asthma control and quality …

This study tests a program called iCHART, designed to help teens aged 12-18 who have depression or suicidal thoughts. The program connects them to mental health care and safety planning. Researchers hope it will reduce suicide-related events by 50% compared to usual care.

This study tests whether adding a specially trained doula to usual home blood pressure monitoring helps women with pregnancy-related high blood pressure achieve better blood pressure control one year after giving birth. About 454 women who had preeclampsia, eclampsia, or gestatio…

This study looks at two standard surgeries for peri-implantitis, a gum infection around dental implants. About 44 adults will get either resective surgery with implantoplasty (smoothing the implant) or with simple cleaning. Researchers will measure inflammation in blood, gum tiss…

This study tests whether a program that helps neighbors work together and build trust can reduce violence in their community. About 4,600 teens and adults in selected Pittsburgh neighborhoods will take part. Researchers will compare changes in violence rates and community cohesio…

This study tests whether having a doula (a trained birth supporter) can help reduce intimate partner violence and related harms like substance use and depression during pregnancy. About 250 pregnant survivors in the Pittsburgh area will be randomly assigned to receive doula suppo…

This study tests a brief sleep program for depressed adolescents aged 12-18 who get too little sleep or have irregular sleep patterns. The program uses two counseling sessions and a smartphone app to teach healthy sleep habits. Researchers will see if the program is practical and…

This study looks at how stress and sleep affect the mood and brain health of people caring for a loved one with dementia. About 120 caregivers aged 55 and older will receive one of two types of talk therapy. Researchers will track their mood, activity, and brain scans to see whic…

This study tests a program called CARES that helps cancer patients manage their symptoms and improve their quality of life. About 1,750 adults with cancer will take part. The program combines screening and step-by-step care to address issues like pain and depression.

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help men feel less pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR, aromatherapy, both, or standard care. The goa…

This study aims to understand how social media use affects the emotional health of teenagers with depression. Researchers will use brain scans (fMRI) and eye-tracking while teens interact with a realistic social media task. 60 teens aged 13-17 with mild to severe depressive sympt…

This study looks at how children's brains handle speech and language. Researchers will compare brain activity in children who stutter and those who don't using EEG and fMRI scans, along with speech tests. The goal is to understand differences in speech processing, not to provide …

This study uses advanced genetic testing (whole exome and whole genome sequencing) to find the genetic causes of undiagnosed diseases in people of Amish or Mennonite descent. Researchers will analyze DNA from 300 participants to identify disease-causing gene mutations and study h…

This study collects blood, urine, and skin samples from 200 adults with cutaneous T-cell lymphoma, eczema, or atopic dermatitis. The samples are stored and used for current and future research, such as studying proteins in the blood and tissue. Participants must have one of these…

This study compares how patients recover and feel after two types of surgery for esophageal cancer: minimally invasive (smaller cuts) versus open surgery. Researchers will track quality of life, pain, and daily function for up to three years in 3,500 participants. The goal is to …

This study looks at how sleep and body clock disruptions impact the brain's reward and impulse control systems in teenagers. Researchers will monitor sleep, brain activity, and decision-making in 100 healthy high school students. The goal is to understand why poor sleep may incre…

This study is testing whether a smartphone app can help new mothers in Pennsylvania feel supported after giving birth. About 60 participants will use the app for 8 weeks and answer surveys about how easy it is to use and whether it helps them understand important postpartum sympt…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study aims to uncover the genetic causes of biliary atresia, a rare liver disease in newborns that often leads to liver failure and transplant. Researchers will analyze DNA from 1100 children who have had or need a liver transplant. The goal is to find gene patterns that exp…

This study collects tissue and fluid samples from 300 adults with breast lumps or breast cancer to find unique protein patterns. Researchers compare samples from cancerous and healthy tissue to develop better blood tests for diagnosis and prognosis. Participants must be 18 or old…

This study tests a digital program called Flourish (formerly imHere4U) designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will be randomly assigned to either use Flourish plus fill out questionnaires or just fill out questionn…

This study looks at how to help pediatric primary care offices work together more effectively to manage children's behavior problems and ADHD. Researchers will compare different strategies to support care teams and practice leaders. About 450 children and their families, along wi…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give kaempferol to 120 volunteers and collect blood and urine samples over a short period. The goal is to understand how the body handles this compound,…

This study aims to preserve fertility for up to 500 female patients under 40 who are at risk of infertility due to cancer, autoimmune diseases, or their treatments. Participants will have an ovary surgically removed and frozen for potential future use. Researchers will also study…