University Of Pittsburgh

This study looks at whether allowing slightly higher blood sugar levels in pregnant women with diabetes during labor can reduce the chance of their newborns having dangerously low blood sugar. About 218 women with diabetes who plan to deliver vaginally will be assigned to either …

This study tests whether a special care program helps adults recover from acute kidney injury better than usual care. About 2,145 participants will be randomly assigned to either the program or standard follow-up. The goal is to see if the program leads to fewer days in the hospi…

This study tests a two-step procedure to repair facial defects from injuries in 22 veterans. First, doctors use fresh fat from the patient's own body to fill the defect. Three months later, they use fat that was harvested during the first step and frozen, avoiding a second liposu…

This study tests whether using a bedside ultrasound to measure a neck blood vessel can help doctors give the right amount of fluid-removing medicine to people hospitalized with severe heart failure. The goal is to reduce 30-day hospital readmissions and protect the kidneys. About…

This study tests whether adding a specially trained doula to standard care helps new moms with pregnancy-related high blood pressure get healthier after birth. About 454 women will either get usual blood pressure monitoring or extra support including a doula, weight checks, and b…

This study tests a home blood pressure monitoring program combined with health education and coaching for rural adults with uncontrolled hypertension. About 334 participants will either get the coaching program or a standard health app. The goal is to see if the program lowers bl…

This study tests if transplanting a man's own frozen testicular cells can safely restore his ability to make sperm after treatments like chemotherapy. Ten men who stored tissue before treatment will receive the transplant. The main goal is to see if sperm returns and to check for…

This study compares two standard surgical treatments for peri-implantitis, a gum infection around dental implants. About 44 adults will be randomly assigned to receive either resective surgery with implantoplasty (smoothing the implant) or with simple cleaning. Researchers will m…

This study tests whether a low-energy laser treatment (SLT) works as well as the standard version for glaucoma and high eye pressure. It also checks if getting this low-energy laser once a year helps people avoid needing daily eye drops longer than waiting until the first treatme…

This study tests ways to prevent sexual violence and heavy drinking among college students who are at higher risk, such as those with a history of sexual violence, LGBTQ+ students, and students with disabilities. Researchers will work with campus health and counseling centers to …

This study looks at whether using a penile traction device (RestoreX) for several weeks before getting a penile implant can help increase the length of the implant and improve patient satisfaction. About 48 men with erectile dysfunction who are scheduled for implant surgery will …

This study tests a mobile app designed to help teenagers who struggle with binge eating or overeating and are overweight. The app uses proven strategies to improve self-control and eating habits. Fifty teens will use the app for 16 weeks and share their feedback on how helpful an…

This study tests a program that combines medication and talk therapy to help people on dialysis manage pain, fatigue, and depression. About 424 adults on hemodialysis will take part. The goal is to see if this approach improves their daily symptoms and quality of life.

This study is testing a mobile health system designed to help people with long-term health conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and overall wellness. About 160 participants aged 12 and old…

This study looks at whether a specific yoga practice can help improve memory, attention, and thinking speed in people whose depression is in remission. Researchers will compare a group doing yoga plus their usual care to a group receiving only usual care. The goal is to see if yo…

This study compares two therapy programs that help autistic people manage their emotions. The goal is to see if a program designed specifically for autistic people works better than a general one. About 470 participants will take part, and the therapies will be offered in communi…

This study tests two types of talk therapy—Cognitive Enhancement Therapy and Enriched Supportive Therapy—to see if they can reduce persistent negative symptoms in people with schizophrenia. Negative symptoms include things like lack of motivation, reduced emotional expression, an…

This study tests whether using a virtual reality headset, an aromatherapy patch, or both can help reduce pain, fear, and embarrassment during a prostate biopsy. About 208 men will be randomly assigned to one of four groups: VR only, aromatherapy only, both, or standard care. The …

This study looks at whether cognitive-behavioral therapy (a type of talk therapy) can help cancer patients who feel distressed about stopping immunotherapy. About 100 adults who have had immunotherapy for cancer will take part. The goal is to reduce fear of the cancer coming back…

This study tests a new therapy for people with aphasia (trouble finding words) after a stroke. The approach uses timed naming exercises to balance effort and accuracy, aiming to improve long-term word recall. Thirty adults with chronic aphasia will participate, and their progress…

This study tests a digital program called Flourish (formerly imHere4U) designed to help teenagers aged 12-17 who have been cyberbullied and are at risk for suicide. The program uses text messaging to improve coping skills and reduce distress. Researchers will compare teens who us…

This study tests whether adjusting the timing of word-practice sessions can help people with aphasia (trouble finding words after a stroke) remember words longer and use them in everyday life. About 32 adults who had a stroke at least 6 months ago will practice naming pictures us…

This study tests treatments designed for older adults (50+) who have had a concussion. The goal is to reduce symptoms like headache, dizziness, and fatigue. Researchers will compare different treatment approaches to see which works best. About 50 people will take part.

This study looks at whether yoga can help people who want to quit tobacco by reducing their cravings. About 96 men who are dependent on tobacco will either do yoga or receive standard quitting advice. Researchers will measure cravings and how many people stay tobacco-free for up …

This study tests a brief sleep program for depressed adolescents aged 12-18 who get too little sleep or have irregular sleep patterns. The program uses two sessions and a smartphone app to teach healthy sleep habits. Researchers want to see if it's practical and helpful for impro…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 participants to receive either remote feedback or be placed on a waitlist. The goal is to see if online coaching can boos…

This study is creating a large research registry of people diagnosed with emphysema, as well as a control group without lung disease. Researchers will collect DNA, lung function tests, and medical information to better understand the disease and identify candidates for future tre…

This study looks at how cannabis use and stopping it affect sleep, daily rhythms, and sensitivity to light in healthy young adults aged 18-25. Researchers will compare regular cannabis users to non-users using sleep monitors and light tests. The goal is to understand how cannabis…

This study looks at whether a safe, widely available heart ultrasound test can identify people at high risk for a second stroke when the first stroke had no clear cause. Researchers will measure how well the heart's upper chamber functions in 900 adults who have had a stroke. If …

This study looks at how harm reduction care—a non-judgmental approach that focuses on safety and health—affects stigma and health outcomes for people with HIV who use drugs. Researchers will survey 768 patients and providers at three HIV clinics to understand how provider attitud…

This study looks at how a ketogenic diet changes brain activity, metabolism, and mood in adults with bipolar disorder. Researchers will use brain scans and blood tests to understand these effects. The goal is to learn more about the diet's potential benefits, not to test it as a …

This study tests a training program for college health and counseling providers to improve their knowledge and skills in caring for transgender and gender diverse students. The goal is to make health centers more welcoming and accessible, which may help lower rates of sexual viol…

This study aims to find genetic traits that may explain why some people develop pulmonary fibrosis and why scarring patterns differ. Researchers will collect blood samples from 2,000 adults diagnosed with pulmonary fibrosis to analyze specific gene variations. The goal is to bett…

This study looks at how changing carbon dioxide levels in the blood affects eye pressure and the thickness of a layer in the back of the eye (the choroid) in children. Researchers will adjust CO2 levels during routine eye exams under anesthesia and measure the eye's response. The…

This study follows 1500 people with rare genetic brain diseases to learn how these conditions progress over time. Researchers measure thinking, movement, and daily living skills, and look for markers in blood and brain scans. The goal is to better understand these disorders and h…

This study aims to find genetic and immune system changes that cause lung cancer to start and grow. Researchers will collect tissue samples from 6,000 people who have or may have lung cancer. The goal is to identify markers that could predict lung cancer risk.

This study collects and analyzes tumor samples and genetic material from people with skull base tumors to learn more about these rare growths. Researchers aim to understand the molecular and cellular makeup of the tumors and track patient survival over time. No new treatments are…

This study tests whether a weekly skills group, combining two proven therapies (CBT and DBT), is practical and helpful for teens aged 13-18 who are at high risk for psychosis. Up to 30 participants already receiving care will join the group. Researchers will track attendance, sat…

This study looks at how different nap lengths during night shifts affect blood pressure and job performance. Researchers will have 130 healthcare and public safety workers take naps of varying lengths during simulated night shifts. The goal is to find the best nap duration to pro…

This study looks at whether a tool called MyPath helps women with substance use disorder make informed choices about birth control after having a baby. About 400 women will use the tool during pregnancy or right after giving birth. Researchers will track which birth control metho…

This study follows 7,500 people with and without multiple sclerosis (MS) for up to 30 years. Researchers will track health changes and treatment responses to learn why MS affects people differently. The goal is to make MS care more personalized and effective.

This study tests whether nicotinamide riboside, a vitamin-like supplement, is feasible to use in children and teens with mild to moderate ulcerative colitis. Researchers will track how many patients enroll and complete the study, and look at changes in cell energy centers (mitoch…

This study creates a registry of medical information from up to 5,000 adults with interstitial lung disease. Researchers will collect past, current, and future health records to better understand these lung conditions. No experimental treatments or procedures are involved—only da…

This study looks at how poor sleep and out-of-sync body clocks change the brain circuits that control reward and self-control in teenagers. Researchers will track sleep, body clock timing, and brain activity in 100 healthy high school students. The goal is to understand why some …

This study explores whether the brain activity patterns linked to a person's mood on one day can be recreated on another day. Researchers will record brain waves and happiness levels in 60 adults who experience mood swings. The goal is to understand if we can 'restore' a previous…

This study looks at how sleep and body rhythms influence teen brain function and the risk of using substances like alcohol or drugs. Researchers will monitor 200 healthy teens aged 13-18 using sleep tests and saliva samples. The goal is to understand these connections, not to tes…

This study is testing a mobile health app designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. About 100 participants will use the app and give feedback to make it more useful. The goal is to see if the app is practic…

This study aims to find the best way to record electrical signals from the stomach using a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS). Researchers will test different stimulation settings and locations in healthy adults to see what tri…

This study aims to understand the genetic and molecular causes of liver cancer in children. Researchers will analyze DNA and other biological markers from up to 1,600 participants, including children treated for liver tumors and their biological parents or siblings. The goal is t…